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Your Position: Home > All Other Proteins > IL-17 RC > ILC-H5259

Human IL-17 RC Protein, Fc Tag (MALS verified)

  • Synonym
    IL-17 RC,IL-17RC,IL17Rhom,IL-17 receptor C,IL-17RL,ZcytoR14
  • Source
    Human IL-17 RC, Fc Tag (ILC-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Ala 465 (Accession # NP_703190.2).
    Predicted N-terminus: Leu 21
  • Molecular Characterization
    Online(Leu 21 - Ala 465) NP_703190.2

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 75.9 kDa. The protein migrates as 90-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) SDS-PAGE gel

Human IL-17 RC, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human IL-17 RC, Fc Tag (Cat. No. ) MALS images

The purity of Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) was more than 90% and the molecular weight of this protein is around 200-230 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human IL-17 RC, Fc TagHuman IL-17 RC, Fc Tag (Cat. No. ILC-H5259) ELISA bioactivity

Immobilized Human IL17A, Tag Free (Cat. No. ILA-H5118) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with a linear range of 4-125 ng/mL (QC tested).

Human IL-17 RC, Fc TagHuman IL-17 RC, Fc Tag (Cat. No. ILC-H5259) ELISA bioactivity

Immobilized Human IL-17F, His Tag (Cat. No. ILF-H5244) at 2 μg/mL (100 μL/well) can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with a linear range of 0.02-0.25 μg/mL (Routinely tested).

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-17A Protein, Tag Free (Cat. No. ILA-H5118) immobilized on CM5 Chip can Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 72.8 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human IL-17A Protein, His,Avitag™ (Cat. No. ILA-H82Q1) captured on Biotin CAP - Series S sensor Chip can bind Human IL-17 RC, Fc Tag (Cat. No. ILC-H5259) with an affinity constant of 40.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

  • Background
    Interleukin-17 receptor C (IL-17 RC), also known as IL17Rhom, IL-17RL, is the receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. IL-17A activity is inhibited by IL-17RA, IL-17F is inhibited by IL-17RC, and a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. Furthermore, activation of IL17RC can lead to the induction of expression of inflammatory chemokines and cytokines such as CXCL1.
  • References
    • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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    Order Details

    Price(USD) : $300.00

    Price(USD) : $1980.00

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