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Your Position: Home > All Other Proteins > Furin > FUN-H52H3

Human Furin / PCSK3 Protein, His Tag

INTRODUCTION

QC & Assay Protocol

Citation & Background

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.

Synonym
FURIN,FUR,PACE,PCSK3,SPC1
Source
Human Furin, His Tag (FUN-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 108 - Glu 715 (Accession # P09958).
Predicted N-terminus: Asp 108
Molecular Characterization
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 67.5 kDa .
Endotoxin

Formulation
Please contact us for detailed information.
Contact us for customized product form or formulation.
Storage
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. The product MUST be stored at -70°C or lower upon receipt;
2. -70^°C for 3 months under sterile conditions.
Shipping
This product is supplied as sterile liquid solution and shipped frozen with dry ice, please inquire the shipping cost.

Background
Furin is also known as paired basic Amino acid Cleaving Enzyme (PACE), is an enzyme which belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. Furin is enriched in the Golgi apparatus, where it functions to cleave other proteins into their mature/active forms. The expression of furin in T-cells is required for maintenance of peripheral immune tolerance. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). PACE is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. In addition to processing cellular precursor proteins, furin is also utilized by a number of pathogens. For example, the envelope proteins of viruses such as HIV, influenza and dengue fever viruses must be cleaved by furin or furin-like proteases to become fully functional. PACE also play a role in tumor progression.
References
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.