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Your Position: Home > All Other Proteins > TL1A > TLA-H5243

Human TL1A / TNFSF15 Protein, His Tag (MALS verified)

  • Synonym
    TL1A, VEGI-251, TNFSF15
  • Source
    Human TL1A, His Tag (TLA-H5243) is expressed from human 293 cells (HEK293). It contains AA Leu 72- Leu 251 (Accession # O95150-1).
    Predicted N-terminus: His
  • Molecular Characterization
    Online(Leu 72- Leu 251) O95150-1

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 22.4 kDa. The protein migrates as 26 kDa and 28-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human TL1A, His Tag (Cat. No. TLA-H5243) SDS-PAGE gel

Human TL1A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Human TL1A, His Tag (Cat. No. ) MALS images

The purity of Human TL1A, His Tag(Cat. No. TLA-H5243) was more than 85% and the molecular weight of this protein is around 78-90 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human TL1A, His TagHuman TL1A, His Tag (Cat. No. TLA-H5243) ELISA bioactivity

Immobilized Human DcR3, Fc Tag (Cat. No. TNB-H5255) at 5 μg/mL (100 μL/well) can bind Human TL1A, His Tag (Cat. No. TLA-H5243) with a linear range of 0.3-2 ng/mL (QC tested).

  • Background
    TNF-like cytokine 1A (TL1A) and its receptors, death receptor 3 (DR3) and decoy receptor 3 (DcR3) are members of the TNF and TNF receptor superfamilies of proteins, respectively. Binding of APC-derived TL1A to lymphocytic DR3 provides co-stimulatory signals for activated lymphocytes. DR3 signaling affects not only the proliferative activity of and cytokine production by effector lymphocytes, but also critically influences the development and suppressive function of regulatory T-cells. Whereas, DcR3 restricts the function of the TL1A/DR3 complex: attenuating T-cell activation and downregulating the secretion of pro-inflammatory cytokines. Together with DR3 and DcR3, TL1A constitutes a cytokine system that actively interferes with the regulation of immune responses.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $350.00

Price(USD) : $2310.00

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