Nanodiscs are a new class of model membranes that are being used to solubilize and study a range of integral membrane proteins (mp, GPRC5D) and membrane-associated proteins. The Nanodisc bilayer is bounded by a membrane scaffold protein (MSP1D1) coat that confers enhanced stability and a narrow particle size distribution. The GPRC5D nanodisc assembles from a mixture of GPRC5D protein in detergent, phospholipid micelles and membrane scaffold protein (MSP1D1) upon removal of the detergent.
This protein carries a Flag tag at the N-terminus and a polyhistidine tag at the C-terminus with calculated MW of 51.8 kDa and migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. The membrane scaffold protein (MSP1D1) has calculated MW of 24.7 kDa, and it migrates as 25 kDa under reducing (R) condition (SDS-PAGE).
>90% as determined by SDS-PAGE.
Supplied as 0.2 μm filtered solution in 50 mM HEPES, 150 mM NaCl, pH7.5 with glycerol as protectant.
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Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
Human GPRC5D, Flag,His Tag (Nanodisc) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
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