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Your Position: Home > Immune Checkpoint Proteins > CD40 > CD0-R52H9

Rabbit CD40 / TNFRSF5 Protein, His Tag (MALS verified)

  • Synonym
    CD40,Bp50,CDW40,MGC9013,TNFRSF5,p50
  • Source
    Rabbit CD40, His Tag (CD0-R52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 77 - Arg 249 (Accession # G1SPC6-1).
    Predicted N-terminus: Glu 77
  • Molecular Characterization
    Online(Glu 77 - Arg 249) G1SPC6-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 20.9 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Rabbit CD40, His Tag (Cat. No. CD0-R52H9) SDS-PAGE gel

Rabbit CD40, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

SEC-MALS
Rabbit CD40, His Tag (Cat. No. ) MALS images

The purity of Rabbit CD40, His Tag (Cat. No. CD0-R52H9) was more than 90% and the molecular weight of this protein is around 20-30 kDa verified by SEC-MALS.

Bioactivity-ELISA
Rabbit CD40, His TagRabbit CD40, His Tag (Cat. No. CD0-R52H9) ELISA bioactivity

Immobilized Rabbit CD40, His Tag (Cat. No. CD0-R52H9) at 5 μg/mL (100 μL/well) can bind Human CD40 Ligand, Fc Tag (active trimer) (MALS verified) (Cat. No. CDL-H5269) with a linear range of 0.2-1 ng/mL (QC tested).

Rabbit CD40, His TagRabbit CD40, His Tag (Cat. No. CD0-R52H9) ELISA bioactivity

Immobilized Rabbit CD40, His Tag (Cat. No. CD0-R52H9) at 5 μg/mL (100 μL/well) can bind Anti-CD40 Antibody, Human IgG2 with a linear range of 0.2-2 ng/mL (Routinely tested).

  • Background
    Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $300.00

Price(USD) : $1980.00

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