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Your Position: Home > All Other Proteins > MAdCAM-1 > MAM-H5253

Human MAdCAM-1 Protein, Fc Tag (MALS verified)

  • Synonym
    MAdCAM-1,Mucosal vascular addressin cell adhesion molecule 1 transcript variant 1
  • Source
    Human MAdCAM-1, Fc Tag (MAM-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Gln 333 (Accession # Q4PKD0-1).
    Predicted N-terminus: Gln 19
  • Molecular Characterization
    Online(Gln 19 - Gln 333) Q4PKD0-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 59.6 kDa. The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by reduced SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) SDS-PAGE gel

Human MAdCAM-1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human MAdCAM-1, Fc Tag (Cat. No. ) MALS images

The purity of Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) was more than 90% and the molecular weight of this protein is around 145-175 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human MAdCAM-1, Fc TagHuman MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) ELISA bioactivity

Immobilized Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT7-H52W4) at 1 μg/mL (100 μL/well) can bind Human MAdCAM-1, Fc Tag (Cat. No. MAM-H5253) with a linear range of 2-78 ng/mL (QC tested).

  • Background
    The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease. In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $300.00

Price(USD) : $1980.00

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  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 3 Clinical

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