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Your Position: Home > Cytokines > IL-20 R alpha > ILA-H525d

Human IL-20 R alpha Protein, Fc Tag (MALS verified)

  • Synonym
    Interleukin-20 receptor subunit alpha,IL-20 receptor subunit alpha,IL-20R-alpha,IL-20RA,Cytokine receptor class-II member 8,Cytokine receptor family 2 member 8,CRF2-8,IL-20R1,ZcytoR7
  • Source
    Human IL-20 R alpha, Fc Tag (ILA-H525d) is expressed from human 293 cells (HEK293). It contains AA Val 30 - Lys 250 (Accession # Q9UHF4-1).
    Predicted N-terminus: Val 30
  • Molecular Characterization
    Online(Val 30 - Lys 250) Q9UHF4-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.7 kDa. The protein migrates as 65-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) SDS-PAGE gel

Human IL-20 R alpha, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human IL-20 R alpha, Fc Tag (Cat. No. ) MALS images

The purity of Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) is more than 90% and the molecular weight of this protein is around 114-140 kDa verified by SEC-MALS.

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human IL-20, His Tag immobilized on CM5 Chip can bind Human IL-20 R alpha, Fc Tag (Cat. No. ILA-H525d) with an affinity constant of 4.42 μM as determined in a SPR assay (Biacore 8K) (QC tested).

  • Background
    The IL-20 receptor alpha subunit forms a functional heterodimer with the IL-20 beta subunit, and transduces ligand-binding at least in part through STAT3 activation.The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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