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Your Position: Home > Receptor > KIR2DL2 > KI2-H5255

Human KIR2DL2 / CD158b1 / NKAT-6 Protein, Fc Tag

  • Synonym
    CD158b1
  • Source
    Human KIR2DL2, Fc Tag (KI2-H5255) is expressed from human 293 cells (HEK293). It contains AA His 22 - His 245 (Accession # P43627-1).
    Predicted N-terminus: His 22
  • Molecular Characterization
    Online(His 22 - His 245) P43627-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 51.0 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris 100 mM Glycine,25 mM Argine,150 mM NaCl,pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) SDS-PAGE gel

Human KIR2DL2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA
Human KIR2DL2, Fc TagHuman KIR2DL2, Fc Tag (Cat. No. KI2-H5255) ELISA bioactivity

Immobilized Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) at 1 μg/mL (100 μL/well) can bind Lirilummab with a linear range of 0.1-8 μg/mL (QC tested).

Bioactivity-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Biotinylated Human HLA-C*07:02:01 & B2M & RYR ,His,Avitag™&Tag Free (Cat. No. HLR-H52W2) immobilized on SA Chip can bind Human KIR2DL2, Fc Tag (Cat. No. KI2-H5255) with an affinity constant of 1.01 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    Killer cell immunoglobulin-like receptor 2DL2(KIR2DL2), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells. KIR2DL2 and KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human leukocyte antigen-C1 (HLA-C1) group of molecules. KIR2DL2, KIR2DL3 and HLA-C1 are highly polymorphic, with this variation being associated with differences in the onset and progression of some human diseases.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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