Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Protein > Cadherin-17 > CA7-C52H4

Cynomolgus Cadherin-17 / CDH17 Protein, His Tag

Order Now

  • Synonym
    Cadherin-17,CDH17,HPT-1,LI-cadherin
  • Source
    Cynomolgus Cadherin-17, His Tag(CA7-C52H4) is expressed from human 293 cells (HEK293). It contains AA Lys 30 - Thr 792 (Accession # A0A2K5X8I8-1).
    Predicted N-terminus: Lys 30
  • Molecular Characterization
    Cadherin-17 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 86.6 kDa. The protein migrates as 100-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >85% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, 0.5 M Arginine, pH8.0 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cadherin-17 SDS-PAGE

Cynomolgus Cadherin-17, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 85%.

Bioactivity-ELISA
 Cadherin-17 ELISA

Immobilized Cynomolgus Cadherin-17, His Tag (Cat. No. CA7-C52H4) at 1 μg/mL (100 μL/well) can bind Human Anti-Cadherin 17 with a linear range of 2-39 ng/mL (QC tested).

Bioactivity-SPR
 Cadherin-17 SPR

Anti-CDH17-antibody captured on Protein A Chip can bind Cynomolgus Cadherin-17, His Tag (Cat. No. CA7-C52H4) with an affinity constant of 41.8 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

  • Background
    Cadherin-17, also known as liver-intestine (LI) Cadherin, belongs to the cadherin family of calcium-dependent cell adhesion molecules. In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
  • Clinical and Translational Updates

Comments (0)


ETD of in-stock products: 2 business days

Price(USD) : $400.00

Price(USD) : $2800.00

Recommended Products
Monoclonal Anti-His Tag Antibody

Price(USD) : $240.00

Price(USD) : $1580.00

HRP conjugated Anti-His Tag Antibody

Price(USD) : $250.00

Price(USD) : $1680.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Phase 2 Clinical

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

Related Products

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message