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Your Position: Home > TME Relevant Pathway > Integrin alpha V beta 5 > IT5-R52E3

Rat Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free

This product is still under development. Please contact us if you have interest in this product. We will accelerate the development process accordingly and reserve this product for you as request.
  • Synonym
    Integrin alpha V beta 5,ITGAV&ITGB5
  • Source
    Rat ITGAV&ITGB5 Heterodimer, His Tag&Tag Free(IT5-R52E3) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Pro 988 & Leu 25 - Asn 719 (Accession # NP_001385621.1 & NP_671480.2 ).
    Predicted N-terminus: Phe 31 | Leu 25
  • Molecular Characterization

    The protein has a calculated MW of 113 kDa | 81.7 kDa.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.
  • Clinical and Translational Updates

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Price(USD) : $410.00

Price(USD) : $2800.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Preclinical

Datasheet & Documentation

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DMF (Drug Master File)

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