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Your Position: Home > TME Relevant Pathway > Integrin alpha M beta 2 > IT2-C52E2

Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free (MALS verified)

  • Synonym
    Integrin alpha M beta 2,ITGAM&ITGB2
  • Source
    Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free(IT2-C52E2) is expressed from human 293 cells (HEK293). It contains AA Phe 18 - Pro 1106 (ITGAM) & Gln 17 - Gln 695 (ITGB2) (Accession # A0A8C0M9J9-1 (ITGAM) & Q9TU04-1 (ITGB2)).
    Predicted N-terminus: Phe 18 | Gln 17
  • Molecular Characterization
    Integrin alpha M beta 2 Structure

    The protein has a calculated MW of 128 kDa | 80 kDa. The protein migrates as 80-90 kda and 155-175 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50mM Tris 150mM NaCl PH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Integrin alpha M beta 2 SDS-PAGE

Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free on SDS-PAGE under non-reducing (NR) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Integrin alpha M beta 2 MALS images

The purity of Canine Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer, His Tag&Tag Free (Cat. No. IT2-C52E2) is more than 85% and the molecular weight of this protein is around 226-276 kDa verified by SEC-MALS.

  • Background
    Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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  • Latest Research Phase:Discontinued

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