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Your Position: Home > Protein > CDNF > CDF-M52H3

Mouse CDNF Protein, His Tag (MALS verified)

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  • Synonym
    CDNF;Cerebral dopamine neurotrophic factorarginine-rich;mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; Conserved dopamine neurotrophic factor
  • Source
    Mouse CDNF, His Tag(CDF-M52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Leu 187 (Accession # Q8CC36).
    Predicted N-terminus: Gln 25
  • Molecular Characterization
    CDNF Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 20.4 kDa. The protein migrates as 21-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Sterility
    The sterility testing was performed by membrane filtration method.
  • Mycoplasma
    Negative.
  • Purity

    >95% as determined by SDS-PAGE.

    >95% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
CDNF SDS-PAGE

Mouse CDNF, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
CDNF MALS images

The purity of Mouse CDNF, His Tag (Cat. No. CDF-M52H3) is more than 95% and the molecular weight of this protein is around 18-25 kDa verified by SEC-MALS.

  • Background
    CDNF is a member of the ARMET family and acts as a trophic factor for dopamine neurons. CDNF inhibits the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When CDNF controlled after 6-OHDA-lesioning, it reestablishes the dopaminergic function and inhibits the degeneration of dopaminergic neurons in substantia nigra. CDNF is universally expressed in neuronal and non-neuronal tissues. The highest levels in the brain are found in the optic nerve and corpus callosum.
  • Clinical and Translational Updates

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