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Your Position: Home > Protein > MANF > MAF-H52H3

Human MANF Protein, His Tag (MALS verified)

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  • Synonym
    Mesencephalic astrocyte-derived neurotrophic factor,Arginine-Rich Protein,arginine-rich, mutated in early stage tumors,ARMET,ARP,MANF,mesencephalic astrocyte-derived neurotrophic facto,Protein ARMET
  • Source
    Human MANF Protein, His Tag(MAF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Leu 182 (Accession # P55145 ).
    Predicted N-terminus: Leu 25
  • Molecular Characterization
    MANF Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 20.0 kDa. The protein migrates as 19-21 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 0.1 EU per μg by the LAL method.
  • Sterility
    The sterility testing was performed by membrane filtration method.
  • Mycoplasma
  • Purity

    >95% as determined by SDS-PAGE.

    >98% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

Human MANF Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

MANF MALS images

The purity of Human MANF Protein, His Tag (Cat. No. MAF-H52H3) is more than 98% and the molecular weight of this protein is around 18-26 kDa verified by SEC-MALS.

  • Background
    MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF and its structural homolog CDNF each contain a N-terminal, saposin-like, lipid-binding domain, and a carboxyl-terminal domain that is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinsons disease. Recombinant Human MANF is an 18.1 kDa protein consisting of 158 amino acids, including 8 cysteine residues.
  • Clinical and Translational Updates

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