Mogengel Matrix (GFR Phenol Red Free) (Acro Certified)

Mogengel Matrix (GFR Phenol Red Free) is intended to be used in organoid/3D cell culturing and applications that require extracellular matrix scaffolding. This includes applications including maintaining cellular growth and differentiation of various cell types, including stem, endothelial, epithelial, and others. It is also intended for applications regarding a more demanding preparation of basement membrane such as tubular osteocyte signaling studies or as a base for mouse mammalian epithelial cell expression studies (basement membrane matrices can reduce the background signals triggered by external addition of growth factors).

• Basement membranes are comprised of continuous sheets of a specialized extracellular matrix. It acts an interface between various types of cells, including muscle, neuronal, epithelial, or endothelial cells, along with adjacent stroma. Basement membranes are an essential part in the organization of tissues forming the scaffolding and support for cellular growth and cell layers. They also affect a variety of cellular mechanisms such as adhesion, migration, proliferation, and differentiation. Basement membranes are selectively degraded and regenerated during development and wound healing, forming the base scaffold for tissue reconstruction. Basement membranes also act as a major barrier to invasion by metastatic tumor cells.
• Mogengel Matrix GFR (Growth Factor Reduced) Phenol Red Free is a soluble form of basement membrane that is purified from gene-edited mouse tumor cells grown in LDEV-free mouse populations. Reconstitution into the original basement membrane form occurs at 37℃ and is mainly comprised of laminin, collagen IV, entactin, and heparin sulfate proteoglycan.