Recombinant Monoclonal Anti-CD8 Antibody, Rabbit (3F3)

描述/背景（Background）

This protein is found on thymocytes and mature T cells. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development.

种属（Host Species）

Rabbit

克隆号（Clone）

3F3

适用方法（Application）

IHC

效价（Property）

1：1000

状态（State）

Liquid

阳性对照（Positive Control）

Human Tonsil Tissues

克隆类型（Clonality）

Monoclonal

分子别名（Synonym）

CD8

研究领域（Research Field）

Cancer Drug Targets

抗体来源（Source）

Rabbit

同种型（Isotype）

IgG

储存（Storage）

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.