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Your Position: Home > Antibody > EGFR > HGS-S242

Recombinant Monoclonal Anti-EGFR Antibody, Mouse (2A4)

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  • Background
    Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules 13. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance (By similarity).
  • Host Species

    Mouse

  • Clone

    2A4

  • Application

    IHC

  • Property
    1:1000
  • State
    Liquid
  • Positive Control
    Human Placenta Tissues
  • Clonality
    Monoclonal
  • Synonym
    ERBB, ERBB1
  • Research Field
    Cancer Drug Targets
  • Source
    Mouse
  • Isotype
    IgG
  • Storage
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Typical Data
Control Sample
 EGFR CONTROL SAMPLE

Immunohistochemical analysis of paraffin embedded Human placenta Tissues labelled with HGS-S242 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Cancer Sample
 EGFR CANCER SAMPLE EGFR CANCER SAMPLE EGFR CANCER SAMPLE

Immunohistochemical analysis of paraffin embedded human cancer tissue labelled with HGS-S242 at 1/1000 dilution.
Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

  • Clinical and Translational Updates

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Price(USD) : $155.00

Price(USD) : $621.00

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Drug Development Status

  • Number of Launched Drugs:31 Details
  • Number of Drugs in Clinical Trials:169 Details
  • Latest Research Phase:Approved

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