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Your Position: Home > Receptor Tyrosine Kinases > Ephrin-A1 > Human Ephrin-A1 /EFNA1 Protein

Human Ephrin-A1 / EFNA1 Protein, Fc Tag

  • Synonym
    EFNA1,Ephrin-A1,LERK-1,TNFAIP4,EPLG1,B61,ECKLG,EFL1
  • Source
    Human Ephrin-A1, Fc Tag (EF1-H5251) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Ser 182 (Accession # NP_004419).
    Predicted N-terminus: Asp 19
  • Molecular Characterization
    Ephrin-A1(Asp 19 - Ser 182) NP_004419

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 46 kDa. As a result of glycosylation, the protein migrates as 50-55 kDa under reducing (R) condition, and 100-110 kDa under non-reducing (NR) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Ephrin-A1, Fc Tag (Cat. No. EF1-H5251) SDS-PAGE gel

Human Ephrin-A1, Fc Tag on SDS-PAGE under reducing (R) and no-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Ephrin-A1 (EFNA1) is also known as EPLG1, LERK1, TNFAIP4, Immediate early response protein B61, which belongs to the ephrin family. EFNA1 contains one ephrin RBD (ephrin receptor-binding) domain. EFNA1 is cell surface GPI-bound ligand for Eph receptors, and is a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA1 binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. EFNA1 plays an important role in angiogenesis and tumor neovascularization.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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