Acrobiosystems for English
icon_bulk_orderBulk inquiry/Quick order
0
There is no goods in the shopping cart !
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0-9
Your Position: Home > Protein > Integrin alpha 5 beta 1 > IT1-H5214

Human Integrin alpha 5 beta 1 (ITGA5&ITGB1) Heterodimer Protein, Tag Free&Tag Free

Order Now

  • Synonym
    Integrin alpha 5 beta 1,ITGA5&ITGB1
  • Source
    Human ITGA5&ITGB1 Heterodimer Protein, Tag Free&Tag Free(IT1-H5214) is expressed from human 293 cells (HEK293). It contains AA Phe 42 - Tyr 995 & Gln 21 - Asp 728 (Accession # P08648-1 & P05556-1).
    Predicted N-terminus: Phe 42 & Gln 21
  • Molecular Characterization
    Integrin alpha 5 beta 1 Structure

    The protein has a calculated MW of 109.3 kDa & 83.7 kDa. The protein migrates as 130-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Integrin alpha 5 beta 1 SDS-PAGE

Human ITGA5&ITGB1 Heterodimer Protein, Tag Free&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 Integrin alpha 5 beta 1 ELISA

Immobilized Fibronectin fragment, premium grade (Cat. No. FIN-H5113) at 2 μg/mL (100 μL/well) can bind Human ITGA5&ITGB1 Heterodimer Protein, Tag Free&Tag Free (Cat. No. IT1-H5214) with a linear range of 0.15-2.4 ng/mL (QC tested).

  • Background
    The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
  • Clinical and Translational Updates

Comments (0)


ETA of in-stock products: 2 business days

Price(USD) : $410.00

Price(USD) : $3170.00

Promotion & Exhibitions



Drug Development Status

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Approved

Datasheet & Documentation

Request for DMF
DMF (Drug Master File)

New Product Launch

Questions & Comments

This web search service is supported by Google Inc.

totop
Call us
Call us
North America:
+1 800-810-0816 (Toll Free)
Asia & Pacific:
+86 400-682-2521
Fax
Fax
+1 888-377-6111
Address
Address
1 Innovation Way, Newark, DE 19711, USA

Leave a message