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Your Position: Home > Beads > LRRC15 > MBS-K079

Human LRRC15-coupled Magnetic Beads

The Magnetic Stand (Cat.No. MB-01 & Cat.No. MB-02) can be used in conjunction with Beads.

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ItemsSize (2mg)Size(2mg X 5)
Particle size2 μm2 μm
Physical appearancePowder mixturePowder mixture
Amount of Coupled Protein≈406 pmol(25.1μg) FAP protein/mg beads≈406 pmol(25.1μg) FAP protein/mg beads
Capacity>133.3 pmol (20μg) Samrotamab /mg beads>133.3 pmol (20μg) Samrotamab /mg beads
FormulationPBS, pH7.4,with 10% TrehalosePBS, pH7.4,with 10% Trehalose
Reconstitution2mL ultrapure water (1 mg beads/mL)2mL ultrapure water (1 mg beads/mL)
  • Background
    LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
  • Application
    This product is labeled by APC and coupled by CD47 protein in advance, no need to use fluorescent labeled secondary antibody, easy to flow cytometry.
    *The Isotype control (Cat. No. SMB-B01) is sold separately.
  • Reconstitution

    See Certificate of Analysis (CoA) for detailed instruction.

  • Storage
    Store beads at 2° to 8°C and protected from direct light. Do not use after the expiration date shown on the label.Please avoid more than 3 freeze-thaw cycles. Immediate use after reconstitution is highly recommended.
  • Formulation

    Please contact us for detailed information.

    Contact us for customized product form or formulation.

Typical Data
 LRRC15 TYPICAL DATA

Immobilized 25.1μg Biotinylated Human LRRC15 protein to 1mg Beads can bind the Samrotamab with an EC50 of 0.18 μg/mL (QC tested).

  • Clinical and Translational Updates

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  • Number of Drugs in Clinical Trials:0 Details
  • Latest Research Phase:Preclinical

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