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MUC1 Background
MUC1恶性肿瘤细胞中，MUC1则以糖基脱落的形式特异性地过表达于多种癌细胞表面，从而减少细胞之间和细胞外基质（ECM）之间的相互作用，促进肿瘤转移。MUC1已被证实在多种实体瘤的上皮细胞中高表达，包括肺癌、乳腺癌、胃癌、卵巢癌和结直肠癌等。其广泛的肿瘤相关表达特征，使MUC1不仅成为多种实体瘤的重要生物标志物，也成为ADC、抗体药物及细胞疗法等新型治疗手段重点关注的靶点。
Clinical Drug Information
| English Name | Research Code | Highest Development Stage | Company | Indication | Clinical Trial |
|---|---|---|---|---|---|
| Bomtabegagene bavoparvovec | AAV9-GLB1; AXO-AAV-GM1 | Phase 2 Clinical | University Of Massachusetts Medical School | Gangliosidoses | Details |
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