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Amyloid Precursor Protein,Alzheimer disease amyloid protein,APP,Amyloid-beta precursor protein
Human Amyloid Precursor, His Tag (AMR-H52H4) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ala 701 (Accession # P05067-1).
Predicted N-terminus: Leu 18
Request for sequence
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 79.3 kDa. The protein migrates as 80-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Less than 1.0 EU per μg by the LAL method.
>95% as determined by SDS-PAGE.
Lyophilized from 0.22 μm filtered solution in PBS, 0.3 M Arginine, pH7.4. Normally trehalose is added as protectant before lyophilization.
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Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
Amyloid precursor protein (APP) is a type 1 membrane protein with an NH2 -terminal extracellular domain and a COOH-terminal cytosolic tail. The amyloid precursor protein (APP) takes a key role in Alzheimer’s disease (AD) pathogenesis. Processing of APP generates that generates the Aβ peptide, whose accumulation is associated with Alzheimer’s disease.
