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Rabbit CTLA-4 / CD152 Protein, His Tag

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CT4-R52H4-100ug
$360.00
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CT4-R52H4-1mg (500ug × 2)
$2,380.00
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CT4-R52H4
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Product Details
Performance Data
Reviews & Citations
  • Product Details
  • Performance Data
  • Reviews & Citations
  • Important Statement
  • Resources

  • 分子别名（Synonym）

    CTLA4,CD152

  • 表达区间及表达系统（Source）

    Rabbit CTLA-4, His Tag (CT4-R52H4) is expressed from human 293 cells (HEK293). It contains AA Lys 36 - Asp 161 (Accession # P42072-1).

    Predicted N-terminus: Lys 36

    Request for sequence

  • 蛋白结构（Molecular Characterization）

    CTLA-4 Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 15.5 kDa.

  • 内毒素（Endotoxin）

    Less than 1.0 EU per μg by the LAL method / rFC method.

  • 制剂（Formulation）

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • 重构方法（Reconstitution）

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • 存储（Storage）

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.

  • 质量管理控制体系（QMS）

    1. 质量管理体系（ISO, GMP）
    2. 质量优势
    3. 质控流程

Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.