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Your Position: Home > LIV-1

LIV-1

Brief Information

Name:Zinc transporter ZIP6
Target Synonym:LIV-1,LIV1,LIV-1 Protein, Estrogen Regulated,Solute Carrier Family 39 (Metal Ion Transporter), Member 6,Zrt- and Irt-like protein 6,SLC39A6,Estrogen-regulated protein LIV-1,ZIP-6,Zinc transporter ZIP6,Solute Carrier Family 39 (Zinc Transporter), Member 6,
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:Phase 2 Clinical

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Part of Bioactivity data

LV1-H5223-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-LIV-1 mAb captured on CM5 chip via anti-human IgG Fc antibody can bind Human LIV-1, His Tag (Cat. No. LV1-H5223) with an affinity constant of 5.24 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

LV1-H5254-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-LIV-1 mAb immobilized on CM5 can bind Human LIV-1, Fc Tag (Cat. No. LV1-H5254) with an affinity constant of 1.74 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

SLC39A6,LIV-1,ZIP6,Zinc transporter ZIP6,ZIP-6

Background

LIV-1 is also known as SLC39A6, ZIP-6 and Zinc transporter ZIP6. May act as a zinc-influx transporter. Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. Up-regulated by estrogen in breast cancer cells lines.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Ladiratuzumab vedotin SGN-LIV1A; MK-6440; MK6440 Phase 2 Clinical Seattle Genetics Inc, Merck Sharp & Dohme Corp Esophageal Neoplasms; Stomach Neoplasms; Squamous Cell Carcinoma of Head and Neck; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Prostatic Neoplasms; Breast Neoplasms; Esophageal Squamous Cell Carcinoma; Melanoma; Carcinoma, Non-Small-Cell Lung; Adenocarcinoma Details

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