DLL4 Molecule Information
Name:Delta-like protein 4
Target Synonym:Delta-like protein 4;DLL4;Delta4;Drosophila Delta homolog 4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase ?
DLL4 Molecule Synonym Name
DLL4 Molecule Background
Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.
DLL4 Clinical Drug Information
Anti-cancer stem cell monoclonal antibodies (OncoMed)
GITRL-336B22; GITRL-336B3; I/O#2; IO#2; IO#3
21H3RK; MEDI-0639; Anti-DLL-4-MAb, MEDI0639
Small cell lung cancer (SCLC)
OncoMed Pharmaceuticals, GlaxoSmithKline, Celgene
Non small cell lung cancer (NSCLC), Solid tumours, Colorectal cancer, Ovarian cancer, Pancreatic cancer
ABL-001-ABL Bio; ABL001-ABL Bio; NOV-1501
ABL Bio, National OncoVenture, TRIGR Therapeutics
ABT-165; DVD-Ig ABT-165
OncoMed Pharmaceuticals, Celgene
Fallopian tube cancer, Solid tumours, Peritoneum cancer, Ovarian cancer
Regeneron Pharmaceutical, Sanofi
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