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DLL4 Molecule Information

Name:Delta-like protein 4
Target Synonym:Delta-like protein 4;DLL4;Delta4;Drosophila Delta homolog 4
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:7
Lastest Research Phase:Phase ?

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Cat. No. Species Product Description Structure Purity Feature
DL4-H5227 Human Human DLL4 Protein, His Tag
DL4-H5259 Human Human DLL4 Protein, Fc Tag

DLL4 Part of Bioactivity data


Loaded Human NOTCH2, Fc Tag (Cat. No. NO2-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 77.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).


Loaded Human NOTCH1, Fc Tag (Cat. No. NO1-H5255) on Protein A Biosensor, can bind Human DLL4, His Tag (Cat. No. DL4-H5227) with an affinity constant of 67.5 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

DLL4 Molecule Synonym Name


DLL4 Molecule Background

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

DLL4 References

DLL4 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
Anti-cancer stem cell monoclonal antibodies (OncoMed) GITRL-336B22; GITRL-336B3; I/O#2; IO#2; IO#3 Preclinical OncoMed Pharmaceuticals Cancer Details
MEDI-0639 21H3RK; MEDI-0639; Anti-DLL-4-MAb, MEDI0639 Phase Ⅰ MedImmune Small cell lung cancer (SCLC) Details
Demcizumab OMP-21M18; OMP-18M21 Phase Ⅱ OncoMed Pharmaceuticals, GlaxoSmithKline, Celgene Non small cell lung cancer (NSCLC), Solid tumours, Colorectal cancer, Ovarian cancer, Pancreatic cancer Details
TR-009 ABL-001-ABL Bio; ABL001-ABL Bio; NOV-1501 Phase Ⅰ ABL Bio, National OncoVenture, TRIGR Therapeutics Solid tumours Details
Dilpacimab ABT-165; DVD-Ig ABT-165 Phase Ⅱ Abbvie Colorectal cancer Details
Navicixizumab OMP-305B83 Phase Ⅰ OncoMed Pharmaceuticals, Celgene Fallopian tube cancer, Solid tumours, Peritoneum cancer, Ovarian cancer Details
Enoticumab REGN-421; SAR-153192 Phase Ⅰ Regeneron Pharmaceutical, Sanofi Solid tumours Details

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