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DLL4

DLL4 Overview

English NameDelta-like protein 4Approved Drugs0
Drugs in Clinical Trials3Target SynonymDelta-Like Protein 4，Notch Ligand Delta-2，DLL4，Delta4，Delta-Like 4 (Drosophila)，Delta-Like 4 Homolog (Drosophila)，AOS6，Hdelta2，Notch Ligand DLL4，Delta Like Canonical Notch Ligand 4，Delta 4，Delta Ligand 4，Delta-Like 4 Protein，Drosophila Delta Homolog 4，Delta-Like 4 Homolog
Highest Development StagePhase 3 Clinical
English NameDelta-like protein 4
Target SynonymDelta-Like Protein 4，Notch Ligand Delta-2，DLL4，Delta4，Delta-Like 4 (Drosophila)，Delta-Like 4 Homolog (Drosophila)，AOS6，Hdelta2，Notch Ligand DLL4，Delta Like Canonical Notch Ligand 4，Delta 4，Delta Ligand 4，Delta-Like 4 Protein，Drosophila Delta Homolog 4，Delta-Like 4 Homolog
Approved Drugs0
Drugs in Clinical Trials3
Highest Development StagePhase 3 Clinical

DLL4 Product List

  • Product Category

    Protein (10)Cell Grade Beads (4)Kits (2)

  • Product Status

    Launched (16)

  • Species

    Human (13)- (3)

  • Tag

    Fc Tag (6)His Tag (1)His Tag & Avi Tag (2)- (6)Fc Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (7)Biotin-labeled (3)- (6)

Cat. No.SpeciesHostProduct DescriptionStructurePurityFeature
HOT
DL4-H5255
Human
HEK293
Human DLL4 Protein, Fc Tag, premium grade (Flagship)
HOT
DL4-H5259
Human
HEK293
Human DLL4 Protein, Fc Tag, low endotoxin (MALS & SPR verified)
HOT
DL4-H82E6
Human
HEK293
Biotinylated Human DLL4 Protein, His,Avitag™, premium grade
HOT
GMP-DL4H23
Human
HEK293
GMP Biotinylated Human DLL4 Protein, His,Avitag™
HOT
GMP-DL4H27
Human
HEK293
GMP Human DLL4 Protein, Fc Tag (Flagship)
HOT
GMP-DL4H28
Human
HEK293
GMP Human DLL4 Protein, Fc Tag
HOT
MBS-C013
Human
-
ActiveMax® Human DLL4 μBeads, premium grade (for cells)
DL4-H5227
Human
HEK293
Human DLL4 Protein, His Tag, low Endotoxin (MALS verified)
DL4-H5256
Human
HEK293
Human DLL4 Protein, Fc Tag, Research Grade (Flagship)
DL4-H82F7
Human
HEK293
Biotinylated Human DLL4 Protein, Fc,Avitag™, premium grade
Total: 16
  • 1
  • 2

DLL4 Background

Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4), which contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 is involved in the Notch signaling pathway as Notch ligand, which can activates NOTCH1 and NOTCH4. DLL4 is involved in angiogenesis and negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 can bind to Notch-1 and Notch-4.

DLL4 Synonyms

DLL4,Delta4

Clinical Drug Information

English NameResearch CodeHighest Development StageCompanyIndicationClinical Trial
TovecimigES-104; NOV-1501; CTX-009; HD-B001A; HDB001A; TR-009; ABL001; ABL-001Phase 3 ClinicalAbl Bio IncAmpullary Carcinoma; Bile Duct Neoplasms; Biliary Tract Neoplasms; Cholangiocarcinoma; Colonic Neoplasms; Colorectal Neoplasms; Gallbladder Neoplasms; Glioblastoma; Rectal Neoplasms; Solid tumours
Details
NavicixizumabOMP-305B83Phase 3 ClinicalOncomed Pharmaceuticals IncColorectal Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Solid tumours; Stomach Neoplasms; Triple Negative Breast Neoplasms
Details
DilpacimabABT-165; DVD-Ig ABT-165Phase 1 ClinicalAbbvie IncNeoplasms; Solid tumours
Details

Product Reviews

  • A***r2025-11-15
    0People Like
    Human DLL4 Protein, Fc Tag, low endotoxin (MALS & SPR verified)
    I have been using ACRO Biosystems products since 2021, especially DLL4 Fc proteins (DL4-H5259), refer to our published article: https://pubmed.ncbi.nlm.nih.gov/37795096/, where we have used Acro-products and obtained excellent results. I am very satisfied with the consistent quality and reliability of ACRO’s products. Thanks, Ankit Tanwar Staff Scientist AECOM, NY
  • Z***a2022-07-06
    1People Like
    Human DLL4 Protein, Fc Tag, low endotoxin (MALS & SPR verified)
    This product was extremely useful for our T cell work. The vial it came in was easy to use (sometimes you'd be surprised how obtuse the packaging of a compound can be by certain companies) and has not lead to any issues with our research in many months. The only obstacle we have ever faced with adherent cells was as a result of our flat bottom plates being too old (and thus the coating wore off). So this product was more stable and consistent than the plates we put them on!
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