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ROR1

ROR1 Molecule Information

Name:Inactive tyrosine-protein kinase transmembrane receptor ROR1
Target Synonym:EC 2.7.10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase, Receptor-Related 1,DJ537F10.1,NTRKR1,ROR-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 2 Clinical

ROR1 Protein Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
RO1-HF253 Human FITC-Labeled Human ROR1 Protein, Fc Tag
RO1-HF253-structure
RO1-HF253-sds
RO1-HF253-elisa_1
RO1-HF258 Human FITC-Labeled Human ROR1 Protein, His Tag
RO1-HF258-structure
RO1-HF258-sds
RO1-HF258-elisa_1
RO1-H5256 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, Mouse IgG2a Fc Tag
RO1-H5256-structure
RO1-H5256-sds
RO1-H5256-elisa_1
MBR-K009 Human Human ROR1-coupled Magnetic Beads
MBR-K009-elisa_1
RO1-H82E6 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
RO1-H82E6-structure
RO1-H82E6-sds
RO1-H82E6-elisa_1
RO1-H821y Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Avitag™
RO1-H821y-structure
RO1-H821y-sds
RO1-H821y-elisa_1
RO1-R5221 Rat Rat ROR1 Protein, His Tag (MALS verified)
RO1-R5221-structure
RO1-R5221-sds
RO1-H82F4 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc,Avitag™
RO1-H82F4-structure
RO1-H82F4-sds
RO1-H82F4-elisa_1
RO1-H5223 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag
RO1-H5223-structure
RO1-H5223-sds
RO1-H5222 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (165-305, Frizzled domain) Protein, His Tag
RO1-H5222-structure
RO1-H5222-sds
RO1-H5221 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag
RO1-H5221-structure
RO1-H5221-sds
RO1-H5221-elisa_1
RO1-M5250 Mouse Mouse ROR1 Protein, Fc Tag (MALS verified)
RO1-M5250-structure
RO1-M5250-sds
RO1-M5221 Mouse Mouse ROR1 Protein, His Tag
RO1-M5221-structure
RO1-M5221-sds
RO1-H522y Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag (MALS verified)
RO1-H522y-structure
RO1-H522y-sds
RO1-H522y-elisa_1
RO1-H5250 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag (MALS verified)
RO1-H5250-structure
RO1-H5250-sds
RO1-H5250-elisa_1

ROR1 Part of Bioactivity data

RO1-H522y-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Anti-Human ROR1 MAb (Mouse IgG1) on AMC Biosensor, can bind Human / Cynomolgus / Rhesus macaque ROR1, His Tag (Cat. No. RO1-H522y) with an affinity constant of 10.2 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

RO1-H5250-BLI
Human_FcRn_Heterodimer_Protein_Bli

Loaded Anti-Human ROR1 MAb (Mouse IgG1) on AMC Biosensor, can bind Human / Cynomolgus / Rhesus macaque ROR1, Fc Tag (Cat. No. RO1-H5250) with an affinity constant of 0.357 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

ROR1 Molecule Synonym Name

ROR1,NTRKR1

ROR1 Molecule Background

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

ROR1 References

ROR1 Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ROR1R-CAR Phase 1 Clinical The University Of Texas M.D. Anderson Cancer Center, Cll Global Research Foundation Alliance Leukemia Details
NBE-002 NBE-002 Phase 2 Clinical Nbe-Therapeutics Ag Triple Negative Breast Neoplasms Details
Cirmtuzumab UC-961 Phase 2 Clinical University Of California Ovarian Neoplasms; Lymphoma, Mantle-Cell; Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell Details
HG-030 HG-030 Phase 1 Clinical Hitgen Ltd Solid tumours Details
NVG-111 NVG-111 Phase 2 Clinical NovalGen Ltd Lymphoma, Mantle-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details
VLS-101 MK-2140; VLS-101 Phase 2 Clinical Velosbio Lymphoma, B-Cell, Marginal Zone; Triple Negative Breast Neoplasms; Lymphoma, Large B-Cell, Diffuse; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Burkitt Lymphoma; Waldenstrom Macroglobulinemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell Details

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