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Your Position: Home > ROR1

ROR1

Brief Information

Name:Inactive tyrosine-protein kinase transmembrane receptor ROR1
Target Synonym:EC 2.7.10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,NTRKR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase, Receptor-Related 1,DJ537F10.1,ROR-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 3 Clinical

Licensing

Project item Indications Research phase Cooperation demands
BPR202203 Ovarian Cancer PCC License-out or co-development

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Cat. No. Species Product Description Structure Purity Feature
RO1-HP2E3 Human PE-Labeled Human ROR1 Protein, His Tag (Site-specific conjugation)
RO1-HP2E3-structure
RO1-HF253 Human FITC-Labeled Human ROR1 Protein, Fc Tag
RO1-HF253-structure
RO1-HF253-sds
RO1-HF258 Human FITC-Labeled Human ROR1 Protein, His Tag
RO1-HF258-structure
RO1-HF258-sds
RO1-H5256 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, Mouse IgG2a Fc Tag
RO1-H5256-structure
RO1-H5256-sds
MBR-K009 Human Human ROR1-coupled Magnetic Beads
RO1-H82E6 Human Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
RO1-H82E6-structure
RO1-H82E6-sds
RO1-H821y Human Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Avitag™
RO1-H821y-structure
RO1-H821y-sds
RO1-R5221 Rat Rat ROR1 Protein, His Tag (MALS verified)
RO1-R5221-structure
RO1-R5221-sds
RO1-H82F4 Human Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc,Avitag™
RO1-H82F4-structure
RO1-H82F4-sds
RO1-H5223 Human Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag (MALS verified)
RO1-H5223-structure
RO1-H5223-sds
RO1-H5222 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (165-305, Frizzled domain) Protein, His Tag
RO1-H5222-structure
RO1-H5222-sds
RO1-H5221 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag
RO1-H5221-structure
RO1-H5221-sds
RO1-M5250 Mouse Mouse ROR1 Protein, Fc Tag (MALS verified)
RO1-M5250-structure
RO1-M5250-sds
RO1-M5221 Mouse Mouse ROR1 Protein, His Tag
RO1-M5221-structure
RO1-M5221-sds
RO1-H522y Human Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag (MALS verified)
RO1-H522y-structure
RO1-H522y-sds
RO1-H5250 Human Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag (MALS verified) DMF Filed
RO1-H5250-structure
RO1-H5250-sds

Part of Bioactivity data

RO1-HP2E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human ROR1 Protein, His Tag (Cat. No. RO1-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

Protocol
RO1-HF253-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 10 μg/mL of FITC-Labeled Human ROR1, Fc Tag (Cat. No.RO1-HF253) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

Protocol
RO1-H82E6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human ROR1 mAb captured on CM5 chip via anti-mouse antibodies surface can bind Biotinylated Human / Cynomolgus / Rhesus macaque ROR1, His, Avitag (Cat. No. RO1-H82E6) with an affinity constant of 5.81 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol
RO1-H522y-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human ROR1 mAb captured on CM5 chip via anti-mouse antibodies surface can bind Human / Cynomolgus / Rhesus macaque ROR1, His Tag (Cat. No. RO1-H522y) with an affinity constant of 4.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

ROR1,NTRKR1

Background

The biotinylated ROR1 protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-ROR1 antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This ROR1 coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
SIM-201 SIM-201; SIM-0201 Phase 1 Clinical Jiangsu Simcere Pharmaceutical Co Ltd Solid tumours Details
NBE-002 BI-3702025; NBE-002; PNU-159682-anti-ROR1 antibody drug conjugate Phase 2 Clinical Nbe-Therapeutics Ag Solid tumours; Neoplasms; Triple Negative Breast Neoplasms Details
GNC-035 quadr-specific antibody（baili） GNC-035 Phase 1 Clinical Sichuan Baili Pharmaceutical Co Ltd Solid tumours; Hematologic Neoplasms; Breast Neoplasms; Metastatic breast cancer Details
LYL-797 LYL-797 Phase 1 Clinical Lyell Immunopharma Inc Solid tumours; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PRGN-3007 PRGN-3007 Phase 1 Clinical Precigen Inc Hematologic Neoplasms; Solid tumours Details
HG-030 HG-030 Phase 1 Clinical Hitgen Inc Solid tumours Details
EMB-07 EMB-07 Phase 1 Clinical Shanghai Epimab Biotherapeutics, Inc Solid tumours; Neoplasms Details
Zilovertamab UC-961 Phase 3 Clinical University Of California San Diego, Oncternal Therapeutics Inc Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Lymphatic Diseases; Immunoproliferative Disorders; Prostatic Neoplasms, Castration-Resistant; Immune System Diseases; Breast Neoplasms; Lymphoma, Mantle-Cell; Lymphoproliferative Disorders; Lymphoma; Lymphoma, Non-Hodgkin; Leukemia, Lymphocytic, Chronic, B-Cell Details
LCB-71 CS-5001; LCB-71; ABL-202 Phase 1 Clinical Legochem Biosciences Inc, Abl Bio Inc Solid tumours; Hematologic Neoplasms; Lymphoma, B-Cell; Lymphoma Details
ONCT-808 ONCT-808 Phase 2 Clinical Oncternal Therapeutics Inc Lymphoma, B-Cell; Neoplasms Details
Zilovertamab vedotin MK-2140; VLS-101 Phase 3 Clinical Oncternal Therapeutics Inc, University Of California San Diego Lymphoma, Follicular; Carcinoma, Non-Small-Cell Lung; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, T-Cell; Burkitt Lymphoma; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, B-Cell; Neoplasms; Triple Negative Breast Neoplasms; Pancreatic Neoplasms; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Transitional Cell; Stomach Neoplasms; Lymphoma, B-Cell, Marginal Zone; Ovarian Neoplasms; Hematologic Neoplasms Details
NVG-111 NVG-111 Phase 2 Clinical NovalGen Ltd Lymphoma, Mantle-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details

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