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ROR1

Brief Information

Name:Inactive tyrosine-protein kinase transmembrane receptor ROR1
Target Synonym:EC 2.7.10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,NTRKR1,ROR1,Receptor Tyrosine Kinase Like Orphan Receptor 1,Neurotrophic Tyrosine Kinase, Receptor-Related 1,DJ537F10.1,ROR-1
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:8
Lastest Research Phase:Phase 2 Clinical

Product ListCompare or Buy

Cat. No. Species Product Description Structure Purity Feature
RO1-HP2E3 Human PE-Labeled Human ROR1 Protein, His Tag (Site-specific conjugation)
RO1-HP2E3-structure
RO1-HF253 Human FITC-Labeled Human ROR1 Protein, Fc Tag
RO1-HF253-structure
RO1-HF253-sds
RO1-HF253-elisa_1
RO1-HF258 Human FITC-Labeled Human ROR1 Protein, His Tag
RO1-HF258-structure
RO1-HF258-sds
RO1-HF258-elisa_1
RO1-H5256 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, Mouse IgG2a Fc Tag
RO1-H5256-structure
RO1-H5256-sds
RO1-H5256-elisa_1
MBR-K009 Human Human ROR1-coupled Magnetic Beads
MBR-K009-elisa_1
RO1-H82E6 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, His,Avitag™ (MALS verified)
RO1-H82E6-structure
RO1-H82E6-sds
RO1-H82E6-elisa_1
RO1-H82E6-elisa_2
RO1-H821y Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Avitag™
RO1-H821y-structure
RO1-H821y-sds
RO1-H821y-elisa_1
RO1-R5221 Rat Rat ROR1 Protein, His Tag (MALS verified)
RO1-R5221-structure
RO1-R5221-sds
RO1-R5221-elisa_1
RO1-H82F4 Human / Cynomolgus / Rhesus macaque Biotinylated Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc,Avitag™
RO1-H82F4-structure
RO1-H82F4-sds
RO1-H82F4-elisa_1
RO1-H5223 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (308-395, Kringle domain) Protein, His Tag
RO1-H5223-structure
RO1-H5223-sds
RO1-H5222 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (165-305, Frizzled domain) Protein, His Tag
RO1-H5222-structure
RO1-H5222-sds
RO1-H5221 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag
RO1-H5221-structure
RO1-H5221-sds
RO1-H5221-elisa_1
RO1-M5250 Mouse Mouse ROR1 Protein, Fc Tag (MALS verified)
RO1-M5250-structure
RO1-M5250-sds
RO1-M5221 Mouse Mouse ROR1 Protein, His Tag
RO1-M5221-structure
RO1-M5221-sds
RO1-H522y Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, His Tag (MALS verified)
RO1-H522y-structure
RO1-H522y-sds
RO1-H522y-elisa_1
RO1-H522y-elisa_2
RO1-H5250 Human / Cynomolgus / Rhesus macaque Human / Cynomolgus / Rhesus macaque ROR1 Protein, Fc Tag (MALS verified)
RO1-H5250-structure
RO1-H5250-sds
RO1-H5250-elisa_1

Part of Bioactivity data

RO1-HP2E3-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human ROR1 Protein, His Tag (Cat. No. RO1-HP2E3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

RO1-HF253-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

2e5 of anti-ROR1 CAR-293 cells were stained with 100 μL of 10 μg/mL of FITC-Labeled Human ROR1, Fc Tag (Cat. No.RO1-HF253) and negative control protein respectively, FITC signal was used to evaluate the binding activity (QC tested).

RO1-H82E6-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human ROR1 mAb captured on CM5 chip via anti-mouse antibodies surface can bind Biotinylated Human / Cynomolgus / Rhesus macaque ROR1, His, Avitag (Cat. No. RO1-H82E6) with an affinity constant of 5.81 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

RO1-H522y-SPR
Human_FcRn_Heterodimer_Protein_SPR

Anti-Human ROR1 mAb captured on CM5 chip via anti-mouse antibodies surface can bind Human / Cynomolgus / Rhesus macaque ROR1, His Tag (Cat. No. RO1-H522y) with an affinity constant of 4.9 nM as determined in a SPR assay (Biacore T200) (Routinely tested).

Synonym Name

ROR1,NTRKR1

Background

The biotinylated ROR1 protein was conjugated to streptavidin magnetic beads. This pre-coupled magnetic bead product can capture the anti-ROR1 antibody from various assay systems. The beads are in uniform size, narrow size distribution with large surface area and unique surface coating, which can help you get the best performance and highly reproducible results. This ROR1 coupled magnetic beads will bring great convenience with minimum non-specific binding and developed protocols. This ready-to-use product could greatly save your time and hassle.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ROR1R-CAR Phase 1 Clinical The University Of Texas MD Anderson Cancer Center, Cll Global Research Foundation Alliance Leukemia Details
NBE-002 NBE-002 Phase 2 Clinical Nbe-Therapeutics Ag Triple Negative Breast Neoplasms Details
Cirmtuzumab UC-961 Phase 2 Clinical University Of California Ovarian Neoplasms; Lymphoma, Mantle-Cell; Breast Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell Details
HG-030 HG-030 Phase 1 Clinical Hitgen Inc Solid tumours Details
NVG-111 NVG-111 Phase 2 Clinical NovalGen Ltd Lymphoma, Mantle-Cell; Leukemia, Lymphocytic, Chronic, B-Cell Details
VLS-101 VLS-101; MK-2140 Phase 2 Clinical Velosbio, Merck Sharp & Dohme Corp Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large B-Cell, Diffuse; Triple Negative Breast Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Lymphoma, Mantle-Cell; Breast Neoplasms; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Waldenstrom Macroglobulinemia; Burkitt Lymphoma; Leukemia, Lymphocytic, Chronic, B-Cell; Carcinoma, Non-Small-Cell Lung Details
GNC-035 quadr-specific antibody(baili) GNC-035 Phase 1 Clinical Sichuan Baili Pharmaceutical Co Ltd Solid tumours Details

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