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TNF-alpha

TNF-alpha

TNF-alpha Overview

Molecule Name
Tumor necrosis factor α
Synonyms
DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα
Drug Development Progress
Drugs in Clinical Trials60
Approved Drugs69
Highest Development StageApproved
Target Synonym
ICD1，Tumor necrosis factor，Tumor Necrosis Factor (TNF Superfamily， Member 2)，Tumor Necrosis Factor Ligand 1F，Tumor Necrosis Factor-Alpha，TNF Superfamily， Member 2，TNF， Macrophage-Derived，TNF， Monocyte-Derived，APC1 Protein，TNLG1F，DIF，NTF，TNF-a，TNF-alpha，ICD2，N-terminal fragment，TNF，Tumor necrosis factor ligand superfamily member 2，Cachectin，TNFSF2，TNFA
Background
Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimers disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

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  • n***l2025-11-20
    GMP Human TNF-alpha Protein
    Love the consistent activity and freeze/thaw stability! very quick shipping
  • P***s2024-11-15
    Human TNF-alpha Protein, His Tag, active trimer, low endotoxin (MALS verified)
    We used this product to conduct binding affinity measurements with molecular modulators that were designed to bind to TNFα In Vitro. Experiment applied was Microscale Thermophoresis that detects binding and, with dilution series, binding affinity between TNFα and test molecule. Results showed low micro molar binding, which showed that TNFα and test molecule behaved as we hoped for! Now we ordered more of this protein for further tests