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TNF-alpha

TNF-alpha Molecule Information

Name:Tumor necrosis factor ?
Target Synonym:Intracellular domain 1;NTF;Cachectin;TNF-a;TNFSF2;ICD2;TNF;Intracellular domain 2;TNF-alpha;N-terminal fragment;Tumor necrosis factor ligand superfamily member 2;TNFA ;Tumor necrosis factor;Tumor necrosis factor, soluble form;Tumor necrosis factor, membra
Number of Launched Drugs:39
Number of Drugs in Clinical Trials:132
Lastest Research Phase:Approved

TNF-alpha Protein Product ListCompare or Buy

TNF-alpha Molecule Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNF¦Á

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNF¦Á) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha References

TNF-alpha Public Drug Information

Name Research Code Research Phase Company First Brand Name First Approved Country First Indication First Approved Company First Approved Date Indications Clinical Trials
Etanercept biosimilar (Hanwha Chemical) HD-203; MK-8953 Approved Hanwha Chemical Ankylosing Spondylitis (AS), Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Etanercept-szzs GP-2015 Approved Sandoz ERELZI fda Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) SANDOZ 2016-08-30 Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Infliximab TA-650 Approved Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma REMICADE fda Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease CENTOCOR INC 1998-08-24 Pediatric ulcerative colitis, Psoriasis vulgaris, Crohn's disease, Mucocutaneous lymph node syndrome (Kawasaki syndrome), Psoriatic erythroderma, Ankylosing Spondylitis (AS), Uveitis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Behcet's disease, Pediatric Crohn's disease Details
Etanercept biosimilar (Nanogen Biopharmaceutical) Approved Nanogen Biopharmaceutical Co Psoriasis, Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (AXXO) Approved AXXO Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Etanercept biosimilar (AryoGen Biopharma) Approved AryoGen Biopharma Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Certolizumab pegol CZP; CDP-870; PHA-738144,CDP870,PHA738144 Approved UCB CIMZIA fda Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease UCB INC 2008-04-22 Plaque psoriasis, Spondyloarthritis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease Details
Etanercept biosimilar (PROBIOMED) Approved Probiomed Rheumatoid arthritis (RA) Details
Etanercept TNR-001 Approved Amgen, Pfizer, Takeda, Boehringer Ingelheim ENBREL fda Pediatric plaque psoriasis, Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) IMMUNEX 1998-11-02 Juvenile idiopathic arthritis (JIA), Pediatric plaque psoriasis, Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Adalimumab biosimilar (Zydus Cadila) Approved Zydus cadila Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical) Approved Shanghai CP Guojian, Cipla cfda Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA), Plaque psoriasis 2015-01-27 Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Samsung Bioepis) SB-4 Approved Samsung Bioepis etanercept ema Samsung Bioepis NL B.V. 2016-01-13 Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) FKB-327 Approved Fujifilm Kyowa Kirin Biologics, Mylan adalimumab ema Mylan S.A.S. 2018-09-16 Plaque psoriasis, Uveitis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Adalimumab biosimilar (Sandoz) GP-2017 Approved Sandoz adalimumab ema Sandoz GmbH 2018-07-26 Juvenile idiopathic arthritis (JIA), Uveitis, Spondyloarthritis, Pediatric plaque psoriasis, Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease Details
Pomalidomide CC-4047; CDC-394; IMID-4047; IMiD-1 Approved Celgene POMALYST fda Multiple myeloma (MM) CELGENE 2013-02-08 Multiple myeloma (MM) Details
Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) Approved Bionovis, The Instituto Vital Brazil Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease Details
Etanercept biosimilar (Intas Biopharmaceuticals) Approved Intas Biopharmaceuticals Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Etanercept biosimilar (Mochida) LBEC-0101 Approved Mochida, Ayumi 日本 Rheumatoid arthritis (RA), Juvenile idiopathic arthritis (JIA) 持田制药 2018-01-19 00:00:00.0 Juvenile idiopathic arthritis (JIA), Rheumatoid arthritis (RA) Details
Adalimumab-adbm BI-695501 Approved Boehringer Ingelheim CYLTEZO fda Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease BOEHRINGER INGELHEIM 2017-08-25 Juvenile idiopathic arthritis (JIA), Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA) Details
Golimumab CNTO-148; rTNV148B,CNTO148 Approved Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma SIMPONI fda Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA) CENTOCOR ORTHO BIOTECH INC 2009-04-24 Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Infliximab (ABDA) SB-2 Approved Samsung Bioepis, Merck Sharp & Dohme infliximab ema Samsung Bioepis NL B.V. 2016-05-26 Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease Details
Infliximab-qbtx PF-06438179; PF-6438179; GP-1111,PF06438179; PF6438179 Approved Pfizer, Sandoz IXIFI fda PFIZER INC 2017-12-13 Psoriatic erythroderma, Ankylosing Spondylitis (AS), Plaque psoriasis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's disease Details
Pentoxifylline BL-191; EHT-0201; EHT-201 Approved Us Pharm Holdings TRENTAL fda US PHARM HOLDINGS 1984-08-30 Peripheral vascular disorders Details
Infliximab (dyyb) CT-P13,CTP13 Approved Celltrion, Hospira, Nippon Kayaku infliximab ema Pfizer Europe MA EEIG 2013-09-09 Psoriatic erythroderma, Plaque psoriasis, Ankylosing Spondylitis (AS), Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease Details
Adalimumab biosimilar (Fresenius Kabi) MSB-11022 Approved Merck Serono, Fresenius Kabi adalimumab ema Fresenius Kabi Deutschland GmbH 2019-04-02 Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Juvenile rheumatoid arthritis (JRA) Details
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) Approved Hisun-Pfizer Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) Details
PG-201 PG-201,PG 201 Approved ViroMed, PMG Pharm Osteoarthritis (OA) Details
Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen) GS-071; NI-071 Approved Nichi-Iko Pharmaceutical, Aprogen, Zeria, Ayumi Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen) 日本 Rheumatoid arthritis (RA), Psoriasis vulgaris, Psoriatic arthritis, Pustular psoriasis, Crohn's disease, Ulcerative colitis Nichi-Iko Pharmaceutical,Zeria 2017-09-27 00:00:00.0 Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA) Details
Luminol sodium MP-1032,MP1032 Approved Metrio, Selvim Psoriasis, Immunological disorders Details
Adalimumab biosimilar (Amgen) ABP-501 Approved Amgen, Daiichi Sankyo AMJEVITA fda Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA) AMGEN INC 2016-09-23 Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA) Details
Lenalidomide CDC-501; CC-5013; CDC-5013; ENMD-0997; IMID-5013; IMiD-3 Approved Celgene, BeiGene REVLIMID fda Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM) CELGENE 2005-12-27 Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM), Peripheral T cell lymphoma (PTCL) Details
Adalimumab D2E7; LU-200134; ABT-D2E7 Approved Abbvie HUMIRA fda ABBVIE INC 2002-12-31 Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Uveitis, Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA), Pediatric Crohn's disease Details
Infliximab biosimilar (Reliance Life Sciences) BOW-015; R-TPR-015 Approved EPIRUS Biopharmaceuticals, Sun Pharmaceutical Rheumatoid arthritis (RA) Details
Infliximab biosimilar (AXXO) Approved AXXO Autoimmune diseases, Crohn's disease Details
Etanercept biosimilar (Amega Biotech) Approved Amega Biotech Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Mycenax Biotech/TSH Biopharm) E-11; ENIA-11,E11; ENIA11 Approved Mycenax Biotech, TSH Biopharm Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Reliance Life Sciences) R-TPR-021 Approved Reliance Life Sciences, Torrent Pharmaceuticals Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Thalidomide NSC-527179; NSC-66847; K-17,NSC527179; NSC66847; K17,NSC 527179; NSC 66847; K 17 Approved Celgene Thalidomide ema Celgene Europe BV 16/04/2008 Erythema nodosum leprosum (ENL), Multiple myeloma (MM) Details
Anti-tumour necrosis factor-alpha antibody Approved Materia Medica Holding Research and Production Company Osteoarthritis (OA), Rheumatoid arthritis (RA) Details

TNF-alpha Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
tgAAC 94 Phase Ⅱ Armata Pharmaceuticals Rheumatoid arthritis (RA), Periodontal disease Details
Infliximab biobetter (Mabtech/Sorrento) STI-002 Phase Ⅲ Taizhou Mabtech, Sorrento Therapeutics Rheumatoid arthritis (RA) Details
CMAB815 CMAB815,CMAB-815; CMAB 815 IND Filing Shanghai Biomabs, SinoMab Bioscience Ltd Rheumatoid arthritis (RA) Details
Human TNF-α monoclonal antibody( Simcere Pharmaceutical) IND Filing Nanjing XianSheng Dongyuan Pharmaceutical, Shandong Xiansheng Medejin Bio-pharmaceutical, Simcere Unspecified Details
Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) Phase Ⅰ Wuhan Institute of Biological Products Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) Phase Ⅰ Shanghai Xiesheng Pharmaceutical Technology Unspecified Details
Adalimumab biosimilar (Shanghai Maitaiyabo Biotech) IND Filing Shanghai Maitai Yabo Biological Technology Rheumatoid arthritis (RA) Details
Hemay007 Hemay-007,Hemay007 Phase Ⅰ Tianjin Hemay Biotech Rheumatoid arthritis (RA), Inflammatory bowel disease Details
BLX-1002 BLX-1002 Phase Ⅱ Orchid Type 2 diabetes Details
Azacitidine/Lenalidomide Phase Ⅱ Celgene Acute myeloid Leukemia (AML) Details
Adalimumab biosimilar (Bionovis/The Instituto Vital Brazil) Phase Not Specified Bionovis, The Instituto Vital Brazil Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease Details
EYS-606 EYS-606 Phase Ⅱ Eyevensys Uveitis Details
Infliximab biosimilar (Shanghai CP Guojian) Phase Ⅲ Shanghai CP Guojian Rheumatoid arthritis (RA) Details
HMPL-004 (Hutchison Medipharma) HMPL-004 Phase Ⅲ Hutchison Medipharma Ulcerative colitis, Crohn's disease Details
Recombinant anti-TNFα antibody (Sailemin Biotech) IND Filing Hainan Sailemin Biological Technology Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
REN-1654 CPI-1189; REN-1189; REN-1654,REN1654,REN1189,CPI1189 Phase Ⅱ Evotec Postherpetic neuralgia (PHN), Sciatica Details
Adalimumab biosimilar (LG Life Sciences) LBAL Phase Ⅲ LG Chem, Mochida Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Beijing Luzhu Biotechnology) Phase Ⅰ Beijing Luzhu Biotechnology Rheumatoid arthritis (RA) Details
ONO-4007 ONO-4007 Phase Ⅱ Ono Pharmaceutical Cancer chemotherapy Details
Recombinant human anti-TNFα monoclonal antibody (Taizhou Mabtech) IND Filing Taizhou Mabtech Unspecified Details
PUR-0110 PUR-0110; PCT-233 Phase Ⅱ PurGenesis Technologies Ulcerative colitis Details
ISIS-104838 ISIS 104838 Phase Ⅱ Ionis Psoriasis, Rheumatoid arthritis (RA) Details
CC-10015 CC-10015 Phase Ⅰ Celgene Systemic sclerosis Details
LP-0058 LP-0058; LEO-32731,LP0058,LEO32731 Phase Ⅱ Leo Pharma Psoriasis, Atopic dermatitis Details
GSK-2800528 GSK-2800528,GSK 2800528,GSK2800528 Phase Ⅰ GlaxoSmithKline Psoriasis, Inflammation Details
Adalimumab biosimilar (Oncobiologics) ONS-3010 Phase Ⅲ Outlook Therapeutics Plaque psoriasis Details
LY-3114062 LY-3114062,LY3114062 Phase Ⅰ Lilly Arthritis Details
Adalimumab biosimilar (CTTQ Pharma) Phase Ⅰ Chiatai Tianqing (CTTQ) Rheumatoid arthritis (RA) Details
QR-449 QR-440; QR-443; QR-449 Phase Ⅰ ProPhase Labs Cachexia, Metabolic disorders, Pain Details
Infliximab biosimilar (Shanghai Biomabs) CMAB-008 BLA Filing Shanghai Biomabs Rheumatoid arthritis (RA) Details
HP-228 HP-228; ILP-228 Phase Ⅱ Sygnis Obesity, Type 2 diabetes, Postoperative pain, Inflammation Details
Adalimumab biosimilar (Coherus BioSciences) CHS-1420 Phase Ⅲ Coherus Biosciences Plaque psoriasis Details
Adalimumab biosimilar (CinnaGen) Phase Ⅲ CinnaGen Rheumatoid arthritis (RA) Details
Infliximab biosimilar (Biocad) BCD-055 Phase Ⅲ Biocad Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
Infliximab biosimilar (Genor Biopharma) GB-242,GB242 Phase Ⅲ Genor Biopharma Rheumatoid arthritis (RA) Details
CDP-571 CDP-571; BAY-10-3356; cb-0010,CDP 571; BAY 10 3356; cb 0010,CDP571; BAY103356; cb0010 Phase Ⅲ Celltech, Biogen Type 2 diabetes, Septic shock, Rheumatoid arthritis (RA), Crohn's disease Details
Adalimumab biosimilar (Biocad) BCD-057 BLA Filing Biocad Plaque psoriasis, Rheumatoid arthritis (RA) Details
Recombinant anti-TNFα monoclonal antibody (Livzon Group) AT-132; LZM-001 Phase Ⅱ Livzon Group Livzon Pharmaceutical Factory Rheumatoid arthritis (RA) Details
Placulumab ART-621; CEP-37247; PN-0621; Dom-0200 Phase Ⅱ Peptech UK, Domantis, Arana, Teva Psoriasis, Inflammation, Rheumatoid arthritis (RA), Sciatica Details
Recombinant human TNF-α monoclonal antibody (Sinocelltech) SCT-630; SCT630 Phase Ⅰ Sinocelltech Plaque psoriasis, Rheumatoid arthritis (RA) Details
AZD-9773 (BTG) Phase Ⅱ BTG plc, AstraZeneca Septic shock, Sepsis Details
JNJ-63823539 JNJ-63823539 Phase Ⅰ Janssen Rheumatoid arthritis (RA) Details
MM-A01-01 MM-A01-01,MMA0101 Phase Ⅱ Myungmoon Pharm Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Bionovis/The Instituto Vital Brazil) Phase Not Specified Bionovis, The Instituto Vital Brazil Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Hemay-005 Hemay-005,Hemay005 Phase Ⅰ Tianjin Hemay Biotech, Hainan Hailing Chemipharma Corporation Limited Psoriasis Details
Adalimumab biosimilar (Alphamab) KN-002 Phase Ⅰ Alphamab Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Genor Biopharma) BCD-100; GB-232 Phase Ⅰ Genor Biopharma, Biocad Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Danhong Pharma) BC-002 Phase Ⅰ Danhong Pharma Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
NPH-30907 NPH-30907 Phase Ⅱ Piramal Phytocare Fungal infection Details
Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) Phase Ⅰ Tonghua Dongbao Pharmaceutical Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Shanghai Henlius Biotech) HLX-03 BLA Filing Shanghai Henlius Biotech Plaque psoriasis, Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Mylan/Biocon) BMO-2; MYL-1401-A BLA Filing Biocon, Mylan Psoriasis, Rheumatoid arthritis (RA) Details
INDUS-83030 INDUS-83030 Phase Not Specified Indus Biotech Private Limited Rheumatoid arthritis (RA) Details
AMG-548 AMG-548 Phase Ⅰ Amgen Rheumatoid arthritis (RA), Arthritis Details
Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) Phase Ⅰ Qilu Pharmaceutical Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Zenotech Laboratories) Phase Not Specified Zenotech laboratories Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (HEC Pharma) IND Filing HEC Pharm Rheumatoid arthritis (RA) Details
Recombinant chimeric anti-TNFα antibody (Hisun Pharma) HS-626,HS626,HS 626 Phase Ⅰ Hisun Pharm Rheumatoid arthritis (RA) Details
ABT-122 ABT-122; D2E7-GS10-B6-17 Phase Ⅱ Abbvie Rheumatic disorders, Psoriatic arthritis Details
Tumour necrosis factor alpha kinoid TNF-K; TNF-K005 Phase Ⅱ Neovacs Rheumatoid arthritis (RA), Crohn's disease Details
Etanercept biosimilar (Clover Biopharmaceuticals) SCB-808 Phase Ⅰ Clover Biopharmaceuticals Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Qilu Pharmaceutical) QL-0902 BLA Filing Qilu Pharmaceutical Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
IBPM005IX (Inbiopro Solutions) Phase Not Specified Inbiopro Solutions Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Juvenile rheumatoid arthritis (JRA) Details
Etanercept biosimilar (AvesthaGen) Phase Ⅲ Avesthagen Rheumatoid arthritis (RA) Details
K-832 K-832 Phase Ⅱ Kowa Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Momenta Pharmaceuticals) BAX-2923; M-923; BAX-923 Phase Ⅲ Momenta, Shire Plaque psoriasis, Autoimmune diseases, Inflammation, Rheumatoid arthritis (RA) Details
ABP-710 ABP-710 BLA Filing Amgen Rheumatoid arthritis (RA) Details
AN-0128 AN-0128; CRM-0005; ONT-0001,AN0128,ONT0001,CRM0005 Phase Ⅱ Anacor Pharmaceuticals Atopic dermatitis Details
V-565 V-565 Phase Ⅱ VHSquared Crohn's disease Details
Etanercept biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical) BLA Filing Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Rheumatoid arthritis (RA) Details
Anti-tumour necrosis factor alpha (Livzon) Phase Ⅰ Livzon Group Autoimmune diseases Details
Adalimumab with ENHANZE technology (Abbvie) Phase Ⅰ Abbvie Unspecified Details
Recombinant human anti-TNFα monoclonal antibody (Weimingdamu Biotech) Phase Ⅰ Anhui Sinobioway Damu Biomedicine Rheumatoid arthritis (RA) Details
AME-527 AME-527 Phase Ⅱ Applied Molecular Evolution Rheumatoid arthritis (RA) Details
YS-IL6 YS-IL6; YSIL-6; YSIL6-O-RA; YSIL6-T-PS Phase Ⅱ Y's Therapeutics Rheumatoid arthritis (RA) Details
OCT-B201 OCT-B201; BT-201 Phase Ⅰ Oscotec Osteoarthritis (OA) Details
Certolizumab (Intrexon) AG-014 Phase Ⅰ Intrexon Corporation Inflammatory bowel disease Details
DLX-105 DLX-105; ESBA-105 Phase Ⅱ ESBATech, Cell Medica Uveitis, Plaque psoriasis, Crohn's disease, Dry eye disease Details
Etanercept biosimilar (Biotrion) BT-D001 Phase Ⅲ Biotrion Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Shanghai Celgen) Phase Ⅲ Shanghai Celgen Bio Plaque psoriasis Details
Adalimumab biosimilar (Innovent Biologics) IBI-303 BLA Filing Innovent Biologics Ankylosing Spondylitis (AS) Details
AVX-470 AVX-1350; AVX-470; AVX-470h Phase Ⅰ Avaxia Biologics Ulcerative colitis Details
COVA-322 COVA-322 Phase Ⅱ Covagen Plaque psoriasis Details
CYT 007 TNFQb Phase Ⅱ Cytos Psoriasis, Rheumatoid arthritis (RA) Details
MNX-160 LMP-160; MNX-160 Preclinical Nonindustrial source, Macronex Cachexia, Diabetes, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Asthma, Adult respiratory distress syndrome (ADRS) Details
KOB-03 KOB-03 Phase Ⅱ Dong Wha Pharmaceuticals Allergic rhinitis (AR) Details
Adalimumab biosimilar (Alvotech) AVT-02 (Alvotech) Phase Ⅲ Alvotech Plaque psoriasis, Autoimmune diseases Details
BIRB-1017 BIRB-1017 Phase Not Specified Boehringer Ingelheim Psoriasis, Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Pfizer) PF-06410293 BLA Filing Pfizer Ankylosing Spondylitis (AS), Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Behcet's disease, Arthritis Details
Etanercept (Neurokine Pharmaceuticals) NK-001; NP-1 Phase Not Specified Pivot Pharmaceuticals Cognitive disorders Details
ENMD-0995 S-3APG; ENMD-0995 Phase Ⅰ Celgene, Boston Children's Hospital Multiple myeloma (MM) Details
PMI-001 PMI-001,PMI 001,PMI001 Phase Ⅲ Phytomedics Lupus vulgaris, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA) Details
Recombinant anti-TNFα human monoclonal antibody (Jilin Kanghui Biotech) IND Filing Jilin Kanghui Biological Technology Unspecified Details
Adalimumab biosimilar (Hualan Biological Engineering) Phase Ⅰ Hualan Biological Engineering Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Bio-Thera Solutions) BAT-1406 BLA Filing Bio-Thera Solutions Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
Golimumab biosimilar (Bio-thera) BAT-2506 Phase Ⅰ Bio-Thera Solutions Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA) Details
Ozoralizumab ATN-103; PF-05230896; PF-5230896; TS-152 Phase Ⅲ Ablynx, Eddingpharm, Pfizer, Taisho Pharmaceutical Rheumatoid arthritis (RA) Details
DOM-0215 DOM-0215,Dom 0215,Dom0215 Preclinical GlaxoSmithKline Rheumatoid arthritis (RA) Details
Human anti-TNFα monoclonal antibody (DZM Biotech) Phase Ⅰ DZM Biotech Rheumatoid arthritis (RA) Details
YHB-1411-2 YHB-1411-2; YHB1411-2; YHB-14112; MAb YHB1411-2 Phase Ⅰ Yuhan Corporation Rheumatoid arthritis (RA) Details
LY-3114062 LY-3114062; LY3114062 Phase Ⅰ Lilly Arthritis Details
Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) Phase Ⅰ North China Pharmaceutical Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
ABBV-257 ABBV-257; DVD-1; DVD-Ig-1 Phase Ⅰ Abbott Rheumatoid arthritis (RA) Details
NV-52 NV-52; NV-07β Phase Ⅱ Novogen Ulcerative colitis, Crohn's disease, Inflammatory bowel disease Details
Lenercept TNFR55-Ig1; RO-452081; p55TNFR-Ig; NFR55-IgG1 Phase Ⅲ Roche Septic shock, Rheumatoid arthritis (RA) Details
PF-5230905 ATN-192; PF-05230905; PF-5230905 Phase Ⅰ Ablynx Rheumatoid arthritis (RA) Details
Tanfanercept HBM-9036; HL-036 Phase Ⅲ HanAll, Harbour BioMed, Daewoong Dry eye disease Details
UBP1211 UBP-1211,UBP1211; UBP 1211 Phase Ⅲ Jiangsu Zhonghe Medicine, Shanghai Junshi Biosciences Rheumatoid arthritis (RA) Details
Adalimumab biosimilar (Celltrion) CT-P17 IND Filing Celltrion Rheumatoid arthritis (RA) Details
Anti-TNFalpha polyclonal antibody (Verigen) Phase Ⅱ Genzyme, Italchimici Crohn's disease, Rheumatoid arthritis (RA) Details
Etanercept biosimilar (Coherus Biosciences) BAX-2200; CHS-0214 Phase Ⅲ Coherus Biosciences, Daiichi Sankyo Plaque psoriasis, Rheumatoid arthritis (RA) Details
Recombinant human anti-TNFα antibody (Hisun Pharma) HS-016,HS016 BLA Filing Hisun Pharm Ankylosing Spondylitis (AS) Details
SA-13353 DE-096; SA-13353,DE096,SA13353 Phase Ⅱ Santen, Ayumi Rheumatoid arthritis (RA), Diabetic macular edema Details
Adalimumab biosimilar (Dong-A ST/Meiji Seika Pharma) DA-3113; DMB-3113 Phase Ⅰ Dong-A Pharmaceutical, Meiji Seika Pharma Rheumatoid arthritis (RA) Details
Ro-327315 Ro-327315; Ro-32-7315 Phase Ⅰ Roche Rheumatoid arthritis (RA) Details
Etanercept biosimilar (YL Biologics) YLB-113 BLA Filing Lupin, YL Biologics Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA) Details
Recombinant mutant human tumor necrosis factor alpha (State Key Laboratory of Cancer Biology) Phase Ⅱ State Key Laboratory of Cancer Biology Gastric cancer, Colorectal cancer, Lung cancer, Renal carcinoma, Head and neck cancer Details
Recombinant humanized anti-TNFα monoclonal antibody (Shenzhen Main Luck Pharmaceuticals) IND Filing Shenzhen Main Luck Pharmaceuticals Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA) Details
ABX-0401 ABX-0401 Phase Ⅱ Sanofi, Pfizer Immune-inflammatory diseases, Rheumatoid arthritis (RA), Inflammatory bowel disease Details
Adalimumab biosimilar (Prestige BioPharma) PBP-1502 Phase Ⅰ Prestige BioPharma, Huons Arthritis Details
Adalimumab biosimilar (Hetero Drugs) Phase Ⅲ Hetero Drugs Rheumatoid arthritis (RA) Details
BB-2275 BB-2275 Preclinical Vernalis Cachexia, AIDS related cachexia, Cancer related cachexia Details
Recombinant human TNF-α monoclonal antibody(SL Pharma/Combio) KM113 IND Filing Beijing ShuangLu Pharmaceutical, Combio Autoimmune diseases Details
Genz-29155 Genz-29155 Phase Ⅰ Sanofi Transplant rejection, Multiple sclerosis (MS) Details
Doramapimod BIBR-796; BIRB-0796; BIRB-796; BIRB-796-BS,BIBR796,BIRB0796,BIRB796 BS Phase Ⅲ Boehringer Ingelheim Psoriasis Details
Adalimumab biosimilar (Synermore Biologics) SYN-060 IND Filing Synermore Biologics, Lonn Ryonn Pharma Rheumatoid arthritis (RA) Details
OCS-02 OCS-02 Phase Ⅱ Oculis Pharma, Novartis Dry eye disease Details
Adalimumab biosimilar (Eastern Biotech) JY-026,JY026 Phase Ⅰ Eastern Biotech Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Crohn's disease, Rheumatoid arthritis (RA) Details
BCD-121 BCD-121 Phase Ⅰ Biocad Rheumatoid arthritis (RA) Details
Golnerminogene pradenovec ADgvEGR.TNF.11D Phase Ⅲ Asahi Kasei, GenVec, National Cancer Institute Pancreatic cancer Details
Acetylcysteine/Pentoxifylline PTL-202 Phase Ⅰ Pacific Therapeutics, IntelGenx Corp, RA Chem Pharma Idiopathic pulmonary fibrosis (IPF) Details
Wogonin Phase Ⅰ Daewoong, China Pharmaceutical University, Hefei Cosource Medicine Technology, Buchang Pharma Gastric cancer, Leukemia, Liver cancer Details

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