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Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) induces cytotoxicity effect on the WEH1-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 0.013-0.074 ng/mL (Routinely tested).
Neutralization assay shows that the cytotoxicity effect of Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) was inhibited by increasing concentration of Adalimumab. The concentration of TNF-alpha used is 1 ng/mL. The IC50 is 26.8 ng/mL (Routinely tested).
Humira (Adalimumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) with an affinity constant of 0.244 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
Humira (Adalimumab) captured on CM5 chip via anti-human IgG Fc antibodies surface, can bind ActiveMax® Human TNF-alpha, Tag Free, low endotoxin (active trimer) (MALS verified) (Cat. No. TNA-H4211) with an affinity constant of 0.255 nM as determined in a SPR assay (Biacore T200) (Routinely tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Etanercept biosimilar (Samsung Bioepis) | SB-4 | Approved | Samsung Bioepis | Eticovo, Benepali | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Samsung Bioepis Co Ltd | 2016-01-13 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details |
| Anti-tumour necrosis factor-alpha antibody | Approved | Materia Medica Holding Research And Production Company | Artrofoon, Arthrofoon | Arthritis, Rheumatoid; Osteoarthritis | Details | |||||
| Etanercept biosimilar (Mycenax Biotech/TSH Biopharm) | ENIA-11; E-11 | Approved | Mycenax Biotech Inc, Tsh Biopharm | TuNEX | Taiwan | Arthritis, Rheumatoid | null | 2017-01-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Etanercept biosimilar (Nanogen Biopharmaceutical) | Approved | Nanogen Biopharmaceutical Co | Nanercept | Vietnam | Psoriasis; Arthritis, Rheumatoid | Nanogen Biopharmaceutical Co | 2019-01-01 | Arthritis, Rheumatoid; Psoriasis | Details | |
| Infliximab biosimilar (Reliance Life Sciences) | BOW-015; R-TPR-015 | Approved | Epirus Biopharmaceuticals | Infimab | Arthritis, Rheumatoid | Details | ||||
| Adalimumab biosimilar (Mylan/Biocon) | BMO-2; MYL-1401-A | Approved | Biocon | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Mylan Pharmaceuticals Inc | 2020-07-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details | |
| Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) | Approved | Hisun-Pfizer | AnBaiNuo | Mainland China | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Wyeth Europa Ltd | 2010-02-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | |
| Etanercept biosimilar (PROBIOMED) | Approved | Probiomed | Infinitam | Mexico | Arthritis, Rheumatoid | Probiomed | 2014-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (AryoGen Biopharma) | Approved | Aryogen Biopharma | Altebrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |||||
| Etanercept biosimilar (Hanwha Chemical) | HD-203; MK-8953 | Approved | Hanwha Chemical | Davictrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | ||||
| Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) | Approved | Bionovis, The Instituto Vital Brazil | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | ||||||
| Etanercept biosimilar (Shanghai Celgen) | Approved | Shanghai Celgen Bio-Pharmaceutical Co Ltd | Psoriasis | Details | ||||||
| Etanercept biosimilar (Intas Biopharmaceuticals) | Approved | Intas Biopharmaceuticals | Intacept | India | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Intas Biopharmaceuticals | 2015-03-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |
| Adalimumab biosimilar (Amgen) | ABP-501 | Approved | Amgen Inc | Amgevita, Amjevita, Solymbic | EU | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease | Amgen Europe Bv | 2016-09-23 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Crohn Disease | Details |
| Etanercept biosimilar (Amega Biotech) | Approved | Amega Biotech | Enerceptan | Argentina | Arthritis, Rheumatoid | Amega Biotech | 2012-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Mylan) | YLB-113 | Approved | Mylan Nv, Rubin Ltd | Nepexto | EU | Arthritis, Rheumatoid; Psoriasis; Spondylarthropathies; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile | Mylan Ire Healthcare Ltd | 2020-05-20 | Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details |
| Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) | FKB-327 | Approved | Fujifilm Kyowa Kirin Biologics Co Ltd | Hulio | EU | Crohn Disease; Uveitis; Hidradenitis Suppurativa; Colitis, Ulcerative; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid | Mylan Sas | 2018-09-16 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Adalimumab biosimilar (Reliance Life Sciences) | R-TPR-021 | Approved | Reliance Life Sciences | Adfrar IB | India | Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic | Reliance Life Sciences, Torrent Pharma | 2016-01-12 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic | Details |
| Adalimumab biosimilar (Biocad) | BCD-057 | Approved | Biocad | Russian Federation | Psoriasis | Biocad | 2019-03-01 | Psoriasis | Details | |
| Adalimumab biosimilar (Zydus Cadila) | Approved | Zydus Cadila | Exemptia | India | Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic | Zydus Cadila | 2014-12-09 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic | Details | |
| Etanercept biosimilar (Mochida) | LBEC-0101 | Approved | Mochida Pharmaceutical Co Ltd | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid | null | 2018-01-19 | Arthritis, Rheumatoid; Arthritis, Juvenile | Details | |
| PG-201 | PG-201 | Approved | Viromed | Layla | South Korea | Osteoarthritis | Pmg Pharm Co Ltd | 2012-01-01 | Osteoarthritis, Knee; Osteoarthritis | Details |
| Adalimumab biosimilar (Innovent Biologics) | IBI-303 | Approved | Innovent Biologics(Suzhou) Co Ltd | 苏立信 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Innovent Biologics(Suzhou) Co Ltd | 2020-09-02 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details |
| Adalimumab biosimilar (Bio-Thera Solutions) | BAT-1406 | Approved | Bio-Thera Solutions Ltd | 格乐立 | Mainland China | Uveitis; Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease | Bio-Thera Solutions Ltd | 2019-11-04 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Uveitis; Crohn Disease | Details |
| Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical) | 301S | Approved | Shanghai Cp Guojian Pharmaceutical Co Ltd, Cipla Gmbh | Yisaipu, Etacept, 益赛普, Etanar | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Shanghai Cp Guojian Pharmaceutical Co Ltd | 2005-06-20 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Details |
| Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen) | GS-071; NI-071 | Approved | Nichi-Iko Pharmaceutical, Aprogen | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | null | 2017-09-27 | Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | |
| Etanercept | TNR-001 | Approved | Pfizer Pharmaceuticals Ltd (China), Amgen Inc | 恩利, Enbrel, Lifmior | Mainland China | Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid | C.H. Boehringer Sohn Ag & Co. Kg | 1998-11-02 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Pulmonary Fibrosis; Psoriasis; Arthritis, Psoriatic; Asthma; Inflammation; Arthritis; Plaque psoriasis | Details |
| Infliximab | TA-650 | Approved | Janssen Global Services Llc | 类克, Remicade | Japan | Mucocutaneous Lymph Node Syndrome | Mitsubishi Tanabe Pharma, Janssen Global Services Llc | 1998-08-24 | Giant Cell Arteritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Sarcoidosis; Mucocutaneous Lymph Node Syndrome; Psoriasis; Pediatric ulcerative colitis; Colitis, Ulcerative; Arthritis, Psoriatic; Parapsoriasis; Uveitis; Pulmonary Disease, Chronic Obstructive; Crohn Disease; Behcet Syndrome | Details |
| Adalimumab | D2E7; ABT-D2E7; LU-200134 | Approved | Abbvie Inc | 修美乐, Humira, Trudexa | Mainland China | Pediatric Crohn's disease | Abbott Laboratories Ltd | 2002-12-31 | Pyoderma Gangrenosum; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Osteoarthritis, Knee; Arthritis, Psoriatic; Asthma; Uveitis; Hidradenitis Suppurativa; Arthritis; Crohn Disease; Plaque psoriasis | Details |
| Certolizumab pegol | PHA-738144; CDP-870; CZP | Approved | Ucb | Cimzia, Cimziat | Mainland China | Arthritis, Rheumatoid | Ucb Pharma Sa | 2008-04-22 | Infertility, Male; Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Spondylarthritis; Multiple Sclerosis; Psoriasis; Arthritis, Psoriatic; Osteoarthritis, Spine; Crohn Disease; Plaque psoriasis | Details |
| Golimumab | rTNV148B; CNTO-148 | Approved | Janssen Global Services Llc | Simponi aria, Simponi/Simponi aria, Simponi | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Janssen Biologics Bv | 2009-04-24 | Diabetes Mellitus, Type 1; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Asthma; Colitis, Ulcerative; Arthritis, Psoriatic | Details |
| Infliximab biosimilar (Amgen) | ABP-710 | Approved | Amgen Inc | Avsola | United States | Pediatric Crohn's disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Pediatric ulcerative colitis | Amgen Inc | 2019-12-06 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details |
| Adalimumab biosimilar (Celltrion) | CT-P17 | Approved | Celltrion | Yuflyma | EU | Crohn Disease; Uveitis; Arthritis, Rheumatoid; Colitis, Ulcerative; Hidradenitis Suppurativa; Psoriasis; Spondylitis, Ankylosing; Arthritis, Psoriatic | Celltrion Healthcare Hungary Kft | 2021-02-11 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Infliximab biosimilar (AXXO) | Approved | Axxo | Russian Federation | Crohn Disease; Autoimmune Diseases | Axxo | 2013-01-01 | Autoimmune Diseases; Crohn Disease | Details | ||
| Adalimumab biosimilar (Samsung Bioepis) | SB-5 | Approved | Samsung Bioepis | Imraldi, Hadlima | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Samsung Bioepis Co Ltd | 2017-08-24 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Pomalidomide | CDC-394; CC-4047; IMiD-1; IMID-4047 | Approved | Celgene Corp | Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 | Mainland China | Multiple Myeloma | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2013-02-08 | Central Nervous System Neoplasms; Anemia, Sickle Cell; Sarcoma, Kaposi; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Metastasis; Lymphoma, Non-Hodgkin; Primary Myelofibrosis; Lymphoma, Follicular; Prostatic Neoplasms; Sarcoma; Medulloblastoma; Lung Diseases, Interstitial; Multiple Myeloma; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Scleroderma, Systemic; Lymphoma, B-Cell; Bone Marrow Neoplasms; Solid tumours | Details |
| Adalimumab biosimilar (Pfizer) | PF-06410293 | Approved | Pfizer Pharmaceuticals Ltd (China) | Amsparity, Abrilada | EU | Crohn Disease; Uveitis; Psoriasis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative | Pfizer Europe Ma Eeig | 2019-11-15 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Infliximab biosimilar (Merck & Co/Samsung Bioepis) | SB-2 | Approved | Samsung Bioepis, Merck & Co Inc | Renflexis, Flixabi | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Colitis, Ulcerative | Samsung Bioepis Co Ltd | 2016-05-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details |
| Adalimumab biosimilar (Hisun Pharma) | HS-016 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | 安健宁 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Hisun Biopharmaceutical Co Ltd | 2019-12-06 | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details |
| Infliximab biosimilar (Shanghai Biomabs) | CMAB-008; STI-002 | Approved | Shanghai Biomabs Pharmaceuticals Co Ltd | 百类停, 类停 | Mainland China | Pediatric Crohn's disease; Crohn Disease; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Rheumatoid; Psoriasis | Taizhou Mabtech Pharmaceutical Co Ltd | 2021-07-12 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Adalimumab biosimilar (Shanghai Henlius Biotech) | HLX-03 | Approved | Shanghai Henlius Biotech Co Ltd | 汉达远 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Shanghai Henlius Biotech Co Ltd | 2020-12-02 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Plaque psoriasis | Details |
| Adalimumab biosimilar (Boehringer Ingelheim) | BI-695501 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Cyltezo | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Boehringer Ingelheim Gmbh | 2017-08-25 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Luminol sodium | MP-1032 | Approved | Selvim, Metrio | Psoriasis; Immune System Diseases | null | 1997-01-01 | Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis | Details | ||
| Infliximab biosimilar (Celltrion) | CT-P13 | Approved | Celltrion | Remsima, Inflectra, Inflectra/Remsima, Flammegis | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease | Celltrion | 2013-09-09 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Urologic Neoplasms; Crohn Disease | Details |
| Infliximab biosimilar (Pfizer) | PF-6438179; GP-1111; PF-06438179 | Approved | Pfizer Inc | Ixifi, Zessly | Japan | Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Rheumatoid; Arthritis, Psoriatic | Pfizer Inc | 2017-12-13 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Details |
| Etanercept biosimial (Sandoz) | GP-2015 | Approved | Clariant Produkte (Schweiz) Ag | Erelzi | EU | Arthritis, Juvenile; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis | Sandoz Gmbh | 2016-08-30 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details |
| Thalidomide | NSC-66847; NSC-527179; K-17; VP-02 | Approved | Celgene Corp | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Japan | Leprosy, Lepromatous | Fujimoto Pharmaceutical | 1982-01-01 | HIV Infections; Spondylitis, Ankylosing; Myelodysplastic Syndromes; Idiopathic Pulmonary Fibrosis; Multiple Myeloma; HIV Wasting Syndrome; Erythema Nodosum; Leprosy, Lepromatous; Carcinoma, Hepatocellular | Details |
| Lenalidomide | IMID-5013; CDC-5013; CDC-501; ENMD-0997; CC-5013; IMiD-3 | Approved | Celgene Corp | 瑞复美, Revlimid, Revimid (former Brand Name) | EU | Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular | Celgene Europe Bv | 2005-12-27 | Radiculopathy; Carcinoma, Non-Small-Cell Lung; Crohn Disease; Neoplasm Metastasis; Melanoma; Complex Regional Pain Syndromes; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Waldenstrom Macroglobulinemia; Thrombocytopenia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Prostatic Neoplasms; Lymphoma, Follicular; Reflex Sympathetic Dystrophy; Leukemia, Myeloid; Lymphoma, Mantle-Cell; Multiple Myeloma; Smoldering Multiple Myeloma; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Blood Protein Disorders; Leukemia-Lymphoma, Adult T-Cell; Paraproteinemias; Anemia; Lymphoma, B-Cell; HIV Infections; Solid tumours; Hematologic Diseases; Lymphoma, B-Cell, Marginal Zone; Lymphoma, T-Cell, Peripheral | Details |
| Adalimumab biosimilar (Sandoz) | GP-2017 | Approved | Sandoz | Hefiya, Hyrimoz, Halimatoz | United States | Plaque psoriasis; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile | Sandoz Inc | 2018-07-26 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease | Details |
| Adalimumab biosimilar (Fresenius Kabi) | MSB-11022 | Approved | Merck Serono, Fresenius Kabi Ag | Idacio, Kromeya | EU | Psoriasis; Hidradenitis Suppurativa | Fresenius Kabi Deutschland Gmbh | 2019-04-02 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| JNJ-63823539 | JNJ-63823539 | Phase 1 Clinical | Janssen Global Services Llc | Arthritis, Rheumatoid | Details |
| Ozoralizumab | TS-152; ATN-103; PF-5230896; PF-05230896 | Phase 3 Clinical | Ablynx | Arthritis, Rheumatoid | Details |
| Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) | Phase 1 Clinical | Qilu Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | |
| AVX-470 | AVX-470; AVX-1350; AVX-470h | Phase 1 Clinical | Avaxia Biologics | Colitis, Ulcerative | Details |
| IBPM005IX (Inbiopro Solutions) | Clinical | Inbiopro Solutions | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic; Crohn Disease | Details | |
| Adalimumab biosimilar (Genor Biopharma) | GB-232; BCD-100 | Phase 2 Clinical | Genor Biopharma Co Ltd | Carcinoma, Renal Cell; Arthritis, Rheumatoid; Lung Neoplasms; Melanoma | Details |
| Anti-tumour necrosis factor alpha (Livzon) | Phase 1 Clinical | Livzon Pharmaceutical Group Inc | Autoimmune Diseases | Details | |
| Thykamine | PUR-0110; PCT-233 | Phase 3 Clinical | Purgenesis Technologies | Dermatitis; Colitis, Ulcerative; Proctocolitis | Details |
| Etanercept (Neurokine Pharmaceuticals) | NP-1; NK-001 | Clinical | Pivot Pharmaceuticals | Cognition Disorders | Details |
| COVA-322 | COVA-322 | Phase 2 Clinical | Covagen | Psoriasis | Details |
| ABT-122 | ABT-122; D2E7-GS10-B6-17 | Phase 2 Clinical | Abbvie Inc | Arthritis, Rheumatoid; Rheumatic Diseases; Arthritis, Psoriatic | Details |
| Human anti-TNFα monoclonal antibody (DZM Biotech) | Phase 1 Clinical | Daqing Dongzhuming Biotechnology Co Ltd | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Alvotech) | AVT-02 (Alvotech) | Phase 3 Clinical | Alvotech | Autoimmune Diseases; Psoriasis | Details |
| Adalimumab biosimilar (Prestige BioPharma) | PBP-1502 | Phase 1 Clinical | Prestige Biopharma | Arthritis | Details |
| V-565 | V-565 | Phase 2 Clinical | Vhsquared | Colitis, Ulcerative; Crohn Disease | Details |
| Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) | Phase 1 Clinical | Shanghai Harmony Pharmaceutical Technology Co Ltd | Details | ||
| Infliximab biobetter (Mabtech/Sorrento) | STI-002 | Phase 3 Clinical | Taizhou Maibo Taike Biotechnology Co Ltd, Sorrento Therapeutics | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Oncobiologics) | ONS-3010 | Phase 3 Clinical | Outlook Therapeutics | Psoriasis | Details |
| Adalimumab biosimilar (Coherus BioSciences) | CHS-1420 | Phase 3 Clinical | Coherus Biosciences | Psoriasis | Details |
| Adalimumab biosimilar (Hetero Drugs) | Phase 3 Clinical | Hetero Drugs | Arthritis, Rheumatoid | Details | |
| Recombinant human anti-TNFα monoclonal antibody (Weimingdamu Biotech) | Phase 1 Clinical | Anhui Weiming Damu Biomedicine Co Ltd | Arthritis, Rheumatoid | Details | |
| EYS-606 | EYS-606 | Phase 2 Clinical | Eyevensys | Uveitis | Details |
| Adalimumab biosimilar (CinnaGen) | Phase 3 Clinical | Cinnagen | Arthritis, Rheumatoid | Details | |
| Certolizumab (Intrexon) | AG-014 | Phase 1 Clinical | Intrexon Co | Inflammatory Bowel Diseases | Details |
| Infliximab biosimilar (Biocad) | BCD-055 | Phase 3 Clinical | Biocad | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Etanercept biosimilar (Clover Biopharmaceuticals) | SCB-808 | Phase 3 Clinical | Sichuan Sanyecao Bio-Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| OCS-02 | OCS-02; ESBA-1622; LME-636 | Phase 2 Clinical | Oculis Pharma | Dry Eye Syndromes; Uveitis, Anterior; Xerophthalmia | Details |
| Etanercept biosimilar (Coherus Biosciences) | CHS-0214; BAX-2200 | Phase 3 Clinical | Coherus Biosciences | Arthritis, Rheumatoid; Psoriasis | Details |
| HMPL-004 (Hutchison Medipharma) | HMPL-004 | Phase 3 Clinical | Hutchison Medipharma Ltd | Lupus Erythematosus, Systemic; Colitis, Ulcerative; Crohn Disease | Details |
| CC-10015 | CC-10015 | Phase 2 Clinical | Celgene Corp | Sarcoidosis; Multiple Myeloma; Lupus Erythematosus, Systemic | Details |
| Adalimumab biosimilar (LG Life Sciences) | LBAL | Phase 3 Clinical | Mochida Pharmaceutical Co Ltd, Lg Chemical Ltd | Arthritis, Rheumatoid | Details |
| Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) | Phase 3 Clinical | Wuhan Institute Of Biological Products Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Plaque psoriasis | Details | |
| Adalimumab biosimilar (Hualan Biological Engineering) | Phase 3 Clinical | Hualan Genetic Engineering Co Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis | Details | |
| Recombinant anti-TNFα monoclonal antibody (Livzon Group) | AT-132; LZM-001 | Phase 2 Clinical | Livzon Pharmaceutical Group Inc | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Beijing Luzhu Biotechnology) | Phase 1 Clinical | Beijing Lvzhu Biological Technology Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis | Details | |
| Infliximab biosimilar (Genor Biopharma) | GB-242 | Phase 3 Clinical | Genor Biopharma Co Ltd | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) | Phase 3 Clinical | Tonghua Dongbao Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Psoriasis; Plaque psoriasis | Details | |
| Adalimumab biosimilar (Eastern Biotech) | JY-026 | Phase 1 Clinical | Beijing Eastern Biotech Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Crohn Disease | Details |
| Etanercept biosimilar (Suzhou Genemen Biotech) | BF-02; GM-02 | Phase 2 Clinical | Suzhou Genemen Biotech. Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Details |
| Wogonin | Phase 1 Clinical | Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University | Respiratory Tract Infections; Neoplasms | Details | |
| Adalimumab biosimilar (Danhong Pharma) | BC-002 | Phase 3 Clinical | Shandong Danhong Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) | Phase 1 Clinical | North China Pharmaceutical Company Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Autoimmune Diseases; Psoriasis | Details | |
| Recombinant human TNF-α monoclonal antibody (Sinocelltech) | SCT-630 | Phase 3 Clinical | Shenzhou Cell Engineering Co Ltd | Psoriasis; Plaque psoriasis | Details |
| Tanfanercept | HBM-9036; HL-036 | Phase 3 Clinical | Hanall | Dry Eye Syndromes; Xerophthalmia | Details |
| Hemay-005 | Hemay-005 | Phase 3 Clinical | Hainan Hailing Chemipharma Corporation Ltd, Tianjin Hemay Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Behcet Syndrome; Dermatitis, Atopic; Plaque psoriasis | Details |
| Orismilast | LP-0058; LEO-32731 | Phase 2 Clinical | Leo Pharma Inc | Drug-Related Side Effects and Adverse Reactions; Psoriasis; Dermatitis, Atopic | Details |
| Golimumab biosimilar (Bio-thera) | BAT-2506 | Phase 3 Clinical | Bio-Thera Solutions Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Arthritis | Details |
| Adalimumab biosimilar (AXXO) | Clinical | Axxo | Arthritis, Rheumatoid; Arthritis, Psoriatic | Details | |
| LY-3114062 | LY3114062; LY-3114062 | Phase 1 Clinical | Eli Lilly And Company | Arthritis | Details |
| Hemay007 | Hemay-007 | Phase 2 Clinical | Tianjin Hemay Bio-Tech Co Ltd | Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative | Details |
| Infliximab biosimilar (Ospedale San Raffaele) | Phase 1 Clinical | Ospedale San Raffaele | Takayasu Arteritis | Details | |
| CD24-Fc | MK-7110; MK7110; HAS-CD24; CD24-Fc-IgG; CD24-Fc | Phase 3 Clinical | Oncoimmune | HIV Infections; Hematopoietic stem cell transplantation (HSCT); Leukemia; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Dyslipidemias; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Myeloid, Acute; Melanoma | Details |
| Recombinant human anti-TNFα monoclonal antibody (Huaota Biopharma) | Phase 3 Clinical | Shanghai Huaao Tai Biopharma Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis; Plaque psoriasis | Details | |
| Monoclonal Antibody (Mab) sB24M | Phase 1 Clinical | Pyoderma Gangrenosum | Details | ||
| Adalimumab biosimilar (Alphamab) | KN-002 | Phase 1 Clinical | Suzhou Alphamab Co Ltd | Arthritis, Rheumatoid; Asthma | Details |
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