TNF-alpha Protein - ACROBiosystems

TNF-alpha

TNF-alpha Molecule Information

Name：Tumor necrosis factor ?
Target Synonym：Intracellular domain 1?NTF?Cachectin?TNF-a?TNFSF2?ICD2?TNF?Intracellular domain 2?TNF-alpha?N-terminal fragment?Tumor necrosis factor ligand superfamily member 2?TNFA ?Tumor necrosis factor?Tumor necrosis factor, soluble form?Tumor necrosis factor, membra

Number of Launched Drugs：36
Number of Drugs in Clinical Trials：124
Lastest Research Phase：Approved

TNF-alpha Protein Product ListCompare or Buy


TNA-H5228	Human	Human TNF-alpha Protein, His Tag
TNA-M82E9	Mouse	Biotinylated Mouse TNF-alpha (HPLC-verified), Avi Tag (Avitag™)
TNA-H82E3	Human	Biotinylated Human TNF-alpha Protein, His,Avitag™ (HPLC-verified)
TNA-H8211	Human	Biotinylated Human TNF-alpha, epitope tag free, ultra sensitivity (primary amine labeling)
TNA-H4211	Human	ActiveMax® Human TNF-alpha Protein, Tag Free, low endotoxin (HPLC-verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

TNA-H5228

Human

Human TNF-alpha Protein, His Tag

TNA-M82E9

Mouse

Biotinylated Mouse TNF-alpha (HPLC-verified), Avi Tag (Avitag™)

TNA-H82E3

Human

Biotinylated Human TNF-alpha Protein, His,Avitag™ (HPLC-verified)

TNA-H8211

Human

Biotinylated Human TNF-alpha, epitope tag free, ultra sensitivity (primary amine labeling)

TNA-H4211

Human

ActiveMax® Human TNF-alpha Protein, Tag Free, low endotoxin (HPLC-verified)

TNF-alpha Molecule Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNF¦Á

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNF¦Á) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha References

TNF-alpha Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Etanercept biosimilar (Hanwha Chemical)	HD-203; MK-8953	Approved	Hanwha Chemical						Ankylosing Spondylitis (AS), Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Etanercept-szzs	GP-2015	Approved	Sandoz	ERELZI	fda	Ankylosing Spondylitis (AS), Juvenile idiopathic arthritis (JIA), Psoriatic arthritis, Rheumatoid arthritis (RA), Plaque psoriasis	SANDOZ	2016-08-30	Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Infliximab	TA-650	Approved	Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma	infliximab	ema		Janssen Biologics B.V.	1999-08-13	Pediatric ulcerative colitis, Psoriasis vulgaris, Crohn's disease, Mucocutaneous lymph node syndrome (Kawasaki syndrome), Psoriatic erythroderma, Ankylosing Spondylitis (AS), Uveitis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Behcet's disease, Pediatric Crohn's disease	Details
Etanercept biosimilar (AryoGen Biopharma)		Approved	AryoGen Biopharma						Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Certolizumab pegol	CZP; CDP-870; PHA-738144,CDP870,PHA738144	Approved	UCB	CIMZIA	fda	Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	UCB INC	2008-04-22	Plaque psoriasis, Spondyloarthritis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (PROBIOMED)		Approved	Probiomed						Rheumatoid arthritis (RA)	Details
Etanercept	TNR-001; NK-001,TNR001; NK001	Approved	Amgen, Pfizer, Takeda, Boehringer Ingelheim	ENBREL	fda	Pediatric plaque psoriasis, Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	IMMUNEX	1998-11-02	Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Pediatric plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Adalimumab biosimilar (Zydus Cadila)		Approved	Zydus cadila						Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical)		Approved	Shanghai CP Guojian, Cipla		cfda	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA), Plaque psoriasis		2015-01-27	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Samsung Bioepis)	SB-4	Approved	Samsung Bioepis	etanercept	ema		Samsung Bioepis NL B.V.	2016-01-13	Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan)	FKB-327,FKB327; FKB 327	Approved	Fujifilm Kyowa Kirin Biologics, Mylan	adalimumab	ema		Mylan S.A.S.	2018-09-16	Plaque psoriasis, Uveitis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Adalimumab biosimilar (Sandoz)	GP-2017	Approved	Sandoz	adalimumab	ema		Sandoz GmbH	2018-07-26	Juvenile idiopathic arthritis (JIA), Uveitis, Spondyloarthritis, Pediatric plaque psoriasis, Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease	Details
Infliximab biosimilar (Bionovis/The Instituto Vital Brazil)		Approved	Bionovis, The Instituto Vital Brazil						Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (Intas Biopharmaceuticals)		Approved	Intas Biopharmaceuticals						Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Mochida)		Approved	Mochida, Ayumi		日本	Rheumatoid arthritis (RA), Juvenile idiopathic arthritis (JIA)	持田制药	2018-01-19 00:00:00.0	Juvenile idiopathic arthritis (JIA), Rheumatoid arthritis (RA)	Details
Adalimumab-adbm	BI-695501	Approved	Boehringer Ingelheim	CYLTEZO	fda	Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	BOEHRINGER INGELHEIM	2017-08-25	Juvenile idiopathic arthritis (JIA), Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	Details
Golimumab	CNTO-148; rTNV148B,CNTO148	Approved	Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma	SIMPONI	fda	Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	CENTOCOR ORTHO BIOTECH INC	2009-04-24	Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Infliximab-ABDA	SB-2	Approved	Samsung Bioepis, Merck Sharp & Dohme	infliximab	ema		Samsung Bioepis NL B.V.	2016-05-26	Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease	Details
Infliximab-qbtx	PF-06438179; PF-6438179; GP-1111,PF06438179; PF6438179	Approved	Pfizer, Sandoz	IXIFI	fda		PFIZER INC	2017-12-13	Psoriatic erythroderma, Ankylosing Spondylitis (AS), Plaque psoriasis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's disease	Details
Pentoxifylline	BL-191; EHT-0201; EHT-201	Approved	Us Pharm Holdings	TRENTAL	fda		US PHARM HOLDINGS	1984-08-30	Peripheral vascular disorders	Details
Infliximab-dyyb	CT-P13,CTP13	Approved	Celltrion, Hospira, Nippon Kayaku	infliximab	ema		Pfizer Europe MA EEIG	2013-09-09	Psoriatic erythroderma, Plaque psoriasis, Ankylosing Spondylitis (AS), Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease	Details
Adalimumab biosimilar (Merck Serono)	MSB-11022,MSB11022; MSB 11022	Approved	Merck Serono, Fresenius Kabi						Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals)		Approved	Hisun-Pfizer						Rheumatoid arthritis (RA)	Details
PG-201	PG-201,PG 201	Approved	ViroMed, PMG Pharm						Osteoarthritis (OA)	Details
Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)	GS-071; NI-071,GS071; NI071	Approved	Nichi-Iko Pharmaceutical, Aprogen, Zeria, Ayumi	Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)	日本	Rheumatoid arthritis (RA), Psoriasis vulgaris, Psoriatic arthritis, Pustular psoriasis, Crohn's disease, Ulcerative colitis	Nichi-Iko Pharmaceutical,Zeria	2017-09-27 00:00:00.0	Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA)	Details
Adalimumab-ATTO	ABP-501,ABP501	Approved	Amgen, Daiichi Sankyo	AMJEVITA	fda	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	AMGEN INC	2016-09-23	Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Samsung Bioepis)	SB-5	Approved	Samsung Bioepis	adalimumab	ema		Samsung Bioepis NL B.V.	2017-08-24	Pediatric plaque psoriasis, Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Pediatric Crohn's disease	Details
Lenalidomide	CDC-501; CC-5013; CDC-5013; ENMD-0997; IMID-5013; IMiD3,CC 5013,CDC 501,CC5013,CDC501,IMiD-1	Approved	Celgene, BeiGene	REVLIMID	fda	Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM)	CELGENE	2005-12-27	Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM), Peripheral T cell lymphoma (PTCL)	Details
Adalimumab	D2E7; LU-200134; ABT-D2E7	Approved	Abbvie	HUMIRA	fda		ABBVIE INC	2002-12-31	Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Uveitis, Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA), Pediatric Crohn's disease	Details
Infliximab biosimilar (Reliance Life Sciences)	BOW-015; R-TPR-015	Approved	EPIRUS Biopharmaceuticals, Sun Pharmaceutical						Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (AXXO)		Approved	AXXO						Autoimmune diseases, Crohn's disease	Details
Etanercept biosimilar (Amega Biotech)		Approved	Amega Biotech						Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Mycenax Biotech/TSH Biopharm)	E-11; ENIA-11,E11; ENIA11	Approved	Mycenax Biotech, TSH Biopharm						Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Reliance Life Sciences)	R-TPR-021	Approved	Reliance Life Sciences, Torrent Pharmaceuticals						Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Thalidomide	NSC-527179,K 17,NSC527179,NSC66847,K-17,NSC-66847,K17,NSC 527179,NSC 66847	Approved	Celgene	THALOMID	fda	Erythema nodosum leprosum (ENL), Multiple myeloma (MM)	CELGENE	1998-07-16	Erythema nodosum leprosum (ENL), Multiple myeloma (MM)	Details
Anti-tumour necrosis factor-alpha antibody		Approved	Materia Medica Holding Research and Production Company						Osteoarthritis (OA), Rheumatoid arthritis (RA)	Details

TNF-alpha Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
tgAAC 94		Phase Ⅱ	AmpliPhi Biosciences Corporation	Rheumatoid arthritis (RA), Periodontal disease	Details
Infliximab biobetter (Mabtech/Sorrento)	STI-002	Phase Ⅲ	Taizhou Mabtech, Sorrento Therapeutics	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Nanogen Biopharmaceutical)		BLA Filing	Nanogen Biopharmaceutical Co	Psoriasis, Rheumatoid arthritis (RA)	Details
CMAB815	CMAB815,CMAB-815; CMAB 815	IND Filing	Shanghai Biomabs, SinoMab Bioscience Ltd	Rheumatoid arthritis (RA)	Details
Human TNF-α monoclonal antibody( Simcere Pharmaceutical)		IND Filing	Nanjing XianSheng Dongyuan Pharmaceutical, Shandong Xiansheng Medejin Bio-pharmaceutical, Simcere	Unspecified	Details
Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products)		Phase Ⅰ	Wuhan Institute of Biological Products	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine)		Phase Ⅰ	Shanghai Xiesheng Pharmaceutical Technology	Unspecified	Details
Adalimumab biosimilar (Shanghai Maitaiyabo Biotech)		IND Filing	Shanghai Maitai Yabo Biological Technology	Rheumatoid arthritis (RA)	Details
Hemay007	Hemay-007,Hemay007	Phase Ⅰ	Tianjin Hemay Biotech	Rheumatoid arthritis (RA), Inflammatory bowel disease	Details
BLX-1002	BLX-1002	Phase Ⅱ	Orchid	Type 2 diabetes	Details
Adalimumab biosimilar (Bionovis/The Instituto Vital Brazil)		Phase Not Specified	Bionovis, The Instituto Vital Brazil	Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
Infliximab biosimilar (Shanghai CP Guojian Pharmaceutical)		Phase Ⅲ	Shanghai CP Guojian	Rheumatoid arthritis (RA)	Details
HMPL-004 (Hutchison Medipharma)	HMPL-004	Phase Ⅲ	Hutchison Medipharma	Ulcerative colitis, Crohn's disease	Details
Recombinant anti-TNFα antibody (Sailemin Biotech)		IND Filing	Hainan Sailemin Biological Technology	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
OCS-02	OCS-02; ESBA-1622; LME-636	Phase Ⅱ	Oculis Pharma, Novartis	Dry eye disease	Details
REN-1654	CPI-1189; REN-1189; REN-1654,REN1654,REN1189,CPI1189	Phase Ⅱ	Evotec	Postherpetic neuralgia (PHN), Sciatica	Details
Adalimumab biosimilar (LG Life Sciences)	LBAL	Phase Ⅲ	LG Chem, Mochida	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Beijing Luzhu Biotechnology)		Phase Ⅰ	Beijing Luzhu Biotechnology	Rheumatoid arthritis (RA)	Details
ONO-4007	ONO-4007	Phase Ⅱ	Ono Pharmaceutical	Cancer chemotherapy	Details
Recombinant human anti-TNFα monoclonal antibody (Taizhou Mabtech)		IND Filing	Taizhou Mabtech	Unspecified	Details
PUR-0110	PUR-0110; PCT-233	Phase Ⅱ	PurGenesis Technologies	Ulcerative colitis	Details
ISIS-104838	ISIS 104838	Phase Ⅱ	Ionis Pharmaceuticals	Psoriasis, Rheumatoid arthritis (RA)	Details
CC-10015	CC-10015	Phase Ⅰ	Celgene	Systemic sclerosis	Details
LP-0058	LP-0058; LEO-32731,LP0058,LEO32731	Phase Ⅱ	Leo Pharma	Psoriasis, Atopic dermatitis	Details
Adalimumab biosimilar (Oncobiologics)	ONS-3010	Phase Ⅲ	Oncobiologics	Plaque psoriasis	Details
LY-3114062	LY-3114062,LY3114062	Phase Ⅰ	Lilly	Arthritis	Details
Adalimumab biosimilar (CTTQ Pharma)		Phase Ⅰ	Chiatai Tianqing (CTTQ)	Rheumatoid arthritis (RA)	Details
QR-449	QR-440; QR-443; QR-449	Phase Ⅰ	ProPhase Labs	Cachexia, Metabolic disorders, Pain	Details
Infliximab biosimilar (Shanghai Biomabs)		BLA Filing	Shanghai Biomabs	Rheumatoid arthritis (RA)	Details
EYS-606	EYS-606	Phase Ⅱ	Eyevensys	Uveitis	Details
HP-228	HP-228; ILP-228	Phase Ⅱ	Sygnis	Obesity, Type 2 diabetes, Postoperative pain, Inflammation	Details
Adalimumab biosimilar (Coherus BioSciences)	CHS-1420	Phase Ⅲ	Coherus Biosciences	Plaque psoriasis	Details
Adalimumab biosimilar (CinnaGen)		Phase Ⅲ	CinnaGen	Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (Biocad)	BCD-055	Phase Ⅲ	Biocad	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (Genor Biopharma)	GB-242,GB242	Phase Ⅲ	Genor Biopharma	Rheumatoid arthritis (RA)	Details
CDP-571	CDP-571; BAY-10-3356; cb-0010,CDP 571; BAY 10 3356; cb 0010,CDP571; BAY103356; cb0010	Phase Ⅲ	Celltech, Biogen	Type 2 diabetes, Septic shock, Rheumatoid arthritis (RA), Crohn's disease	Details
Adalimumab biosimilar (Biocad)	BCD-057	Phase Ⅲ	Biocad	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα monoclonal antibody (Livzon Group)	AT-132; LZM-001	Phase Ⅱ	Livzon Group Livzon Pharmaceutical Factory	Rheumatoid arthritis (RA)	Details
Placulumab	ART-621; CEP-37247; PN-0621; Dom-0200	Phase Ⅱ	Peptech UK, Domantis, Arana, Teva	Psoriasis, Inflammation, Rheumatoid arthritis (RA), Sciatica	Details
Recombinant human TNF-α monoclonal antibody(Sinocelltech)	SCT-630; SCT630	Phase Ⅰ	Sinocelltech	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
AZD-9773 (BTG)		Phase Ⅱ	BTG plc, AstraZeneca	Septic shock, Sepsis	Details
JNJ-63823539	JNJ-63823539	Phase Ⅰ	Janssen	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Bionovis/The Instituto Vital Brazil)		Phase Not Specified	Bionovis, The Instituto Vital Brazil	Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Hemay-005	Hemay-005,Hemay005	Phase Ⅰ	Tianjin Hemay Biotech, Hannan Hailing Pharmaceutical	Psoriasis	Details
Adalimumab biosimilar (Alphamab)	KN-002	Phase Ⅰ	Alphamab	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Genor Biopharma)	BCD-100; GB-232,BCD100; BCD 100,GB 232	Phase Ⅰ	Genor Biopharma, Biocad	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Danhong Pharma)		Phase Ⅰ	Danhong Pharma	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
NPH-30907	NPH-30907	Phase Ⅱ	Piramal Phytocare	Fungal infection	Details
Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical)		Phase Ⅰ	Tonghua Dongbao Pharmaceutical	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Shanghai Henlius Biotech)	HLX-03,HLX03	BLA Filing	Shanghai Henlius Biotech	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Mylan/Biocon)	BMO-2; MYL-1401-A	BLA Filing	Biocon, Mylan	Psoriasis, Rheumatoid arthritis (RA)	Details
INDUS-83030	INDUS-83030	Phase Not Specified	Indus Biotech Private Limited	Rheumatoid arthritis (RA)	Details
AMG-548	AMG-548	Phase Ⅰ	Amgen	Rheumatoid arthritis (RA), Arthritis	Details
Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical)		Phase Ⅰ	Qilu Pharmaceutical	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (HEC Pharma)		IND Filing	HEC Pharm	Rheumatoid arthritis (RA)	Details
Recombinant chimeric anti-TNFα antibody (Hisun Pharma)	HS-626,HS626	Phase Ⅰ	Hisun Pharm	Rheumatoid arthritis (RA)	Details
ABT-122	ABT-122; D2E7-GS10-B6-17	Phase Ⅱ	Abbvie	Rheumatic disorders, Psoriatic arthritis	Details
Tumour necrosis factor alpha kinoid	TNF-K; TNF-K005	Phase Ⅱ	Neovacs	Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (Clover Biopharmaceuticals)	SCB-808,SCB808	Phase Ⅰ	Clover Biopharmaceuticals	Rheumatoid arthritis (RA)	Details
IBPM005IX (Inbiopro Solutions)		Phase Not Specified	Inbiopro Solutions	Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (AvesthaGen)		Phase Ⅲ	Avesthagen	Rheumatoid arthritis (RA)	Details
K-832	K-832	Phase Ⅱ	Kowa	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Momenta Pharmaceuticals)	BAX-2923; M-923; BAX-923	Phase Ⅲ	Momenta, Shire	Plaque psoriasis, Autoimmune diseases, Inflammation, Rheumatoid arthritis (RA)	Details
ABP-710	ABP-710	BLA Filing	Amgen	Rheumatoid arthritis (RA)	Details
AN-0128	AN-0128; CRM-0005; ONT-0001,AN0128,ONT0001,CRM0005,Borinic acid ester - Anacor	Phase Ⅱ	Anacor Pharmaceuticals	Atopic dermatitis	Details
V-565	V-565	Phase Ⅱ	VHSquared	Crohn's disease	Details
Etanercept biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical)		BLA Filing	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical	Rheumatoid arthritis (RA)	Details
Anti-tumour necrosis factor alpha (Livzon)		Phase Ⅰ	Livzon Group	Autoimmune diseases	Details
Recombinant human anti-TNFα monoclonal antibody (Weimingdamu Biotech)		IND Filing	Anhui Sinobioway Damu Biomedicine	Rheumatoid arthritis (RA)	Details
AME-527	AME-527	Phase Ⅱ	Applied Molecular Evolution	Rheumatoid arthritis (RA)	Details
YS-IL6	YS-IL6; YSIL-6; YSIL6-O-RA; YSIL6-T-PS	Phase Ⅱ	Y's Therapeutics	Rheumatoid arthritis (RA)	Details
OCT-B201	OCT-B201; BT-201	Phase Ⅰ	Oscotec	Osteoarthritis (OA)	Details
Certolizumab (Intrexon)	AG-014	Phase Ⅰ	Intrexon Corporation	Inflammatory bowel disease	Details
DLX-105	DLX-105; ESBA-105	Phase Ⅱ	ESBATech, Cell Medica	Uveitis, Plaque psoriasis, Crohn's disease, Dry eye disease	Details
Etanercept biosimilar (Biotrion)	BT-D001; BTD-001,BT D001; BTD 001,BTD001	Phase Ⅲ	Biotrion	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Shanghai Celgen)		Phase Ⅲ	Shanghai Celgen Bio	Plaque psoriasis	Details
Adalimumab biosimilar (Innovent Biologics)	IBI-303	BLA Filing	Innovent Biologics	Ankylosing Spondylitis (AS)	Details
AVX-470	AVX-1350; AVX-470; AVX-470h	Phase Ⅰ	Avaxia Biologics	Ulcerative colitis	Details
COVA-322	COVA-322	Phase Ⅱ	Covagen	Plaque psoriasis	Details
CYT 007 TNFQb		Phase Ⅱ	Cytos	Psoriasis, Rheumatoid arthritis (RA)	Details
MNX-160	LMP-160; MNX-160	Preclinical	Nonindustrial source, Macronex	Cachexia, Diabetes, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Asthma, Adult respiratory distress syndrome (ADRS)	Details
KOB-03	KOB-03	Phase Ⅱ	Dong Wha Pharmaceuticals	Allergic rhinitis (AR)	Details
GSK-2800528	GSK-2800528	Phase Ⅰ	GlaxoSmithKline	Psoriasis, Inflammation	Details
Adalimumab biosimilar (Alvotech)	AVT-02	Phase Ⅲ	Alvotech	Plaque psoriasis, Autoimmune diseases	Details
BIRB-1017	BIRB-1017	Phase Not Specified	Boehringer Ingelheim	Psoriasis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Pfizer)	PF-06410293	Phase Ⅲ	Pfizer	Ankylosing Spondylitis (AS), Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Behcet's disease, Arthritis	Details
ENMD-0995	S-3APG; ENMD-0995	Phase Ⅰ	Celgene, Boston Children's Hospital	Multiple myeloma (MM)	Details
PMI-001	PMI-001,PMI 001,PMI001	Phase Ⅲ	Phytomedics	Lupus vulgaris, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα human monoclonal antibody (Jilin Kanghui Biotech)		IND Filing	Jilin Kanghui Biological Technology	Unspecified	Details
Adalimumab biosimilar (Hualan Biological Engineering)		Phase Ⅰ	Hualan Biological Engineering	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Bio-Thera Solutions)	BAT-1406	BLA Filing	Bio-Thera Solutions	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Ozoralizumab	ATN-103; PF-05230896; PF-5230896; TS-152	Phase Ⅲ	Ablynx, Eddingpharm, Pfizer, Taisho Pharmaceutical	Rheumatoid arthritis (RA)	Details
DOM-0215	DOM-0215,Dom 0215,Dom0215	Preclinical	GlaxoSmithKline	Rheumatoid arthritis (RA)	Details
Human anti-TNFα monoclonal antibody (DZM Biotech)		Phase Ⅰ	DZM Biotech	Rheumatoid arthritis (RA)	Details
YHB-1411-2	YHB-1411-2; YHB1411-2; YHB-14112; MAb YHB1411-2	Phase Ⅰ	Yuhan Corporation	Rheumatoid arthritis (RA)	Details
Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical)		Phase Ⅰ	North China Pharmaceutical	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
ABBV-257	ABBV-257; DVD-1; DVD-Ig-1	Phase Ⅰ	Abbott	Rheumatoid arthritis (RA)	Details
NV-52	NV-52; NV-07; NV-07b; NV-07beta	Phase Ⅱ	Novogen	Ulcerative colitis, Crohn's disease, Inflammatory bowel disease	Details
Lenercept (Roche)	RO-452081	Phase Ⅲ	Roche	Septic shock, Rheumatoid arthritis (RA)	Details
PF-5230905	ATN-192; PF-05230905; PF-5230905	Phase Ⅰ	Ablynx	Rheumatoid arthritis (RA)	Details
HL-036	HL-036; HBM-9036,HL036; HL 036; HBM9036, HL-036337	Phase Ⅱ	HanAll, Harbour BioMed, Daewoong	Dry eye disease	Details
UBP1211	UBP-1211,UBP1211; UBP 1211	Phase Ⅲ	Jiangsu Zhonghe Medicine, Shanghai Junshi Biosciences	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Celltrion)	CT-P17	IND Filing	Celltrion	Rheumatoid arthritis (RA)	Details
Anti-TNFalpha polyclonal antibody (Verigen)		Phase Ⅱ	Genzyme, Italchimici	Crohn's disease, Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Coherus Biosciences)	BAX-2200; CHS-0214	Phase Ⅲ	Coherus Biosciences, Daiichi Sankyo	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
Recombinant human anti-TNFα antibody (Hisun Pharma)	HS-016	BLA Filing	Hisun Pharm	Ankylosing Spondylitis (AS)	Details
SA-13353	DE-096; SA-13353,DE096,SA13353	Phase Ⅱ	Santen, Ayumi	Rheumatoid arthritis (RA), Diabetic macular edema	Details
Adalimumab biosimilar (Dong-A ST/Meiji Seika Pharma)	DA-3113; DMB-3113	Phase Ⅰ	Dong-A Pharmaceutical, Meiji Seika Pharma	Rheumatoid arthritis (RA)	Details
Ro-327315	Ro-327315; Ro-32-7315	Phase Ⅰ	Roche	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (YL Biologics)	YLB-113	BLA Filing	Lupin, YL Biologics	Rheumatoid arthritis (RA)	Details
Recombinant humanized anti-TNFα monoclonal antibody (Shenzhen Main Luck Pharmaceuticals)		IND Filing	Shenzhen Main Luck Pharmaceuticals	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
ABX-0401	ABX-0401	Phase Ⅱ	Sanofi, Pfizer	Immune-inflammatory diseases, Rheumatoid arthritis (RA), Inflammatory bowel disease	Details
Adalimumab biosimilar (Hetero Drugs)		Phase Ⅲ	Hetero Drugs	Rheumatoid arthritis (RA)	Details
BB-2275	BB-2275	Preclinical	Vernalis	Cachexia, AIDS related cachexia, Cancer related cachexia	Details
Recombinant human TNF-α monoclonal antibody(SL Pharma/Combio)	KM113	IND Filing	Beijing ShuangLu Pharmaceutical, Combio	Autoimmune diseases	Details
Infliximab biosimilar (Shanghai biomabs)	CMAB-008	Phase Ⅲ	Shanghai Biomabs, SinoMab Bioscience Ltd	Rheumatoid arthritis (RA)	Details
Genz-29155	Genz-29155	Phase Ⅰ	Sanofi	Transplant rejection, Multiple sclerosis (MS)	Details
Doramapimod	BIBR-796; BIRB-0796; BIRB-796; BIRB-796-BS,BIBR796,BIRB0796,BIRB796 BS	Phase Ⅲ	Boehringer Ingelheim	Psoriasis	Details
Adalimumab biosimilar (Synermore Biologics)	SYN-060,SYN060; SYN 060	IND Filing	Synermore Biologics, Lonn Ryonn Pharma	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Eastern Biotech)	JY-026,JY026	Phase Ⅰ	Eastern Biotech	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Crohn's disease, Rheumatoid arthritis (RA)	Details
BCD-121	BCD-121	Phase Ⅰ	Biocad	Rheumatoid arthritis (RA)	Details
Golnerminogene pradenovec	ADgvEGR.TNF.11D	Phase Ⅲ	Asahi Kasei, GenVec, National Cancer Institute	Pancreatic cancer	Details
Acetylcysteine/Pentoxifylline; Oxpentifylline	PTL-202	Phase Ⅰ	Pacific Therapeutics, IntelGenx Corp, RA Chem Pharma	Idiopathic pulmonary fibrosis (IPF)	Details
Wogonin		Phase Ⅰ	Daewoong, China Pharmaceutical University, Hefei Cosource Medicine Technology, Buchang Pharma	Gastric cancer, Leukemia, Liver cancer	Details