| Project item | Indications | Research phase | Cooperation demands |
| BHE202204 | Idiopathic Pulmonary Fibrosis (IPF) | Phase 2 | License-out or co-development |
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Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) induces cytotoxicity effect on the WEH1-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The EC50 for this effect is 0.013-0.074 ng/mL (Routinely tested).
Neutralization assay shows that the cytotoxicity effect of Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) was inhibited by increasing concentration of Adalimumab. The concentration of TNF-alpha used is 1 ng/mL. The IC50 is 26.8 ng/mL (Routinely tested).
Biotinylated Monoclonal Anti-TNF-alpha antibody, human IgG1 (16H5) (Cat. No. TNA-BLM494) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (active trimer) (MALS verified) (Cat. No. TNA-H5228) with an affinity constant of 75.9 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Monoclonal Anti-TNF-alpha antibody, Human IgG1 (13B8) (Cat. No. TNA-AM493) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 0.133 nM as determined in a SPR assay (Biacore 8K) (Routly tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) | Approved | Hisun-Pfizer | AnBaiNuo | Mainland China | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Wyeth Europa Ltd | 2010-02-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | |
| Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) | Approved | Bionovis, The Instituto Vital Brazil | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | ||||||
| Etanercept biosimilar (Intas Biopharmaceuticals) | Approved | Intas Biopharmaceuticals | Intacept | India | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Intas Biopharmaceuticals | 2015-03-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |
| Anti-tumour necrosis factor-alpha antibody | Approved | Materia Medica Holding Research And Production Company | Artrofoon, Arthrofoon | Arthritis, Rheumatoid; Osteoarthritis | Details | |||||
| Etanercept biosimilar (AryoGen Biopharma) | Approved | Aryogen Biopharma | Altebrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |||||
| Etanercept biosimilar (Nanogen Biopharmaceutical) | Approved | Nanogen Biopharmaceutical Co | Nanercept | Vietnam | Psoriasis; Arthritis, Rheumatoid | Nanogen Biopharmaceutical Co | 2019-01-01 | Arthritis, Rheumatoid; Psoriasis | Details | |
| Etanercept biosimilar (PROBIOMED) | Approved | Probiomed | Infinitam | Mexico | Arthritis, Rheumatoid | Probiomed | 2014-01-01 | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Reliance Life Sciences) | R-TPR-021 | Approved | Reliance Life Sciences | Adfrar IB | India | Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic | Reliance Life Sciences, Torrent Pharma | 2016-01-12 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic | Details |
| Infliximab biosimilar (AXXO) | Approved | Axxo | Russian Federation | Crohn Disease; Autoimmune Diseases | Axxo | 2013-01-01 | Autoimmune Diseases; Crohn Disease | Details | ||
| Etanercept biosimilar (Mochida) | LBEC-0101 | Approved | Mochida Pharmaceutical Co Ltd | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid | null | 2018-01-19 | Arthritis, Rheumatoid; Arthritis, Juvenile | Details | |
| Etanercept biosimilar (Amega Biotech) | Approved | Amega Biotech | Enerceptan | Argentina | Arthritis, Rheumatoid | Amega Biotech | 2012-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Mylan) | YLB-113 | Approved | Rubin Ltd, Mylan Nv | Nepexto | EU | Arthritis, Rheumatoid; Spondylarthropathies; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Plaque psoriasis | Mylan Ire Healthcare Ltd | 2020-05-20 | Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Recombinant human type II tumor necrosis factor receptor-antibody fusion protein(Shanghai Cp Guojian) | Approved | Shanghai Cp Guojian Pharmaceutical Co Ltd | 益赛普 | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details | |||||
| Adalimumab biosimilar (CTTQ Pharma) | Approved | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2022-01-18 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | ||
| Adalimumab biosimilar (Jiangsu Zhonghe/Shanghai Junshi/Jiangsu T-Mab) | UBP-1211; 9MW0113; 9-MW-0113; 9-MW0113; 9MW-0113 | Approved | Shanghai Junshi Biosciences Co Ltd, Jiangsu Zhonghe Pharmaceutical Technology Co Ltd, Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd, Mabwell (Shanghai) Bioscience Co Ltd | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Shanghai Junshi Biosciences Co Ltd | 2022-03-01 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details | |
| Infliximab biosimilar (Pfizer) | PF-6438179; GP-1111; PF-06438179 | Approved | Pfizer Inc | Ixifi, Zessly | Japan | Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Rheumatoid; Arthritis, Psoriatic | Pfizer Inc | 2013-09-09 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Pediatric ulcerative colitis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Details |
| Infliximab biosimilar (Shanghai Biomabs) | CMAB-008; STI-002 | Approved | Shanghai Biomabs Pharmaceuticals Co Ltd | 百类停, 类停 | Mainland China | Psoriasis; Arthritis, Rheumatoid; Pediatric Crohn's disease; Crohn Disease; Spondylitis, Ankylosing; Colitis, Ulcerative | Taizhou Mabtech Pharmaceutical Co Ltd | 2021-07-12 | Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Adalimumab biosimilar (Zydus Cadila) | ZRC-3197 | Approved | Zydus Cadila | Exemptia, Adaly | India | Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing | Zydus Cadila | 2014-12-09 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic | Details |
| Adalimumab biosimilar (Hisun Pharma) | HS-016 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | 安健宁 | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Hisun Biopharmaceutical Co Ltd | 2019-12-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Infliximab biosimilar (Hisun Pharma) | HS-626 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | Mainland China | Psoriasis | Hisun Biopharmaceutical Co Ltd | 2021-09-24 | Psoriasis | Details | |
| Etanercept biosimilar (Samsung Bioepis) | SB-4 | Approved | Samsung Bioepis | Eticovo, Benepali | United States | Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis; Spondylitis, Ankylosing; Arthritis, Psoriatic | Samsung Bioepis Co Ltd | 2016-01-13 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details |
| Adalimumab biosimilar (Pfizer) | PF-06410293 | Approved | Pfizer Pharmaceuticals Ltd (China) | Amsparity, Abrilada, Fyzoclad | EU | Crohn Disease; Uveitis; Psoriasis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative | Pfizer Europe Ma Eeig | 2019-11-15 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Infliximab biosimilar (Nichiiko/Aprogen) | NI-071; GS-071; GS-07; AP-07 | Approved | Nichi-Iko Pharmaceutical, Aprogen | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Nichi-Iko Pharmaceutical Co Ltd | 2017-09-27 | Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | |
| Adalimumab biosimilar (Coherus BioSciences) | CHS-1420 | Approved | Coherus Biosciences Inc | Yusimry | United States | Colitis, Ulcerative; Plaque psoriasis; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Crohn Disease | Coherus Biosciences Inc | 2021-12-17 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Plaque psoriasis; Crohn Disease | Details |
| Infliximab biosimilar (Merck & Co/Samsung Bioepis) | SB-2 | Approved | Samsung Bioepis, Merck & Co Inc | Renflexis, Flixabi | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Colitis, Ulcerative | Samsung Bioepis Co Ltd | 2016-05-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details |
| Opinercept | E-11; ENIA-11 | Approved | Tsh Biopharm, Mycenax Biotech Inc | TuNEX | Taiwan | Arthritis, Rheumatoid | null | 2017-01-01 | Arthritis, Rheumatoid | Details |
| Infliximab biosimilar (Celltrion) | CT-P13 | Approved | Celltrion | Remsima, Inflectra, Inflectra/Remsima, Flammegis | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease | Celltrion | 2013-09-10 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Urologic Neoplasms; Crohn Disease | Details |
| PG-201 | PG-201 | Approved | Viromed | Layla | South Korea | Osteoarthritis | Pmg Pharm Co Ltd | 2012-01-01 | Osteoarthritis | Details |
| Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical) | 301S | Approved | Shanghai Cp Guojian Pharmaceutical Co Ltd, Cipla Gmbh | Yisaipu, Etacept, 益赛普, Etanar | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Shanghai Cp Guojian Pharmaceutical Co Ltd | 2005-06-20 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details |
| Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) | FKB-327 | Approved | Fujifilm Kyowa Kirin Biologics Co Ltd | Hulio | EU | Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Uveitis | Viatris Ltd | 2018-09-16 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Samsung Bioepis) | SB-5 | Approved | Samsung Bioepis | Imraldi, Hadlima | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Samsung Bioepis Co Ltd | 2017-08-24 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Shanghai Henlius Biotech) | HLX-03 | Approved | Shanghai Henlius Biotech Co Ltd | 汉达远 | Mainland China | Uveitis, Intermediate; Uveitis, Posterior; Panuveitis | Shanghai Henlius Biotech Co Ltd | 2020-12-02 | Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Uveitis, Posterior; Plaque psoriasis; Panuveitis | Details |
| Adalimumab biosimilar (Biocad) | BCD-057 | Approved | Biocad | Russian Federation | Psoriasis | Biocad | 2019-03-01 | Psoriasis | Details | |
| Adalimumab biosimilar (Bio-Thera Solutions) | BAT-1406 | Approved | Bio-Thera Solutions Ltd | 格乐立 | Mainland China | Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Uveitis | Bio-Thera Solutions Ltd | 2019-11-04 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Innovent Biologics) | IBI-303 | Approved | Innovent Biologics(Suzhou) Co Ltd | 苏立信 | Mainland China | Crohn Disease; Pediatric Crohn's disease | Innovent Biologics(Suzhou) Co Ltd | 2020-09-02 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Uveitis; Plaque psoriasis; Crohn Disease | Details |
| Adalimumab biosimilar (Mylan/Biocon) | BMO-2; MYL-1401-A | Approved | Biocon | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Mylan Pharmaceuticals Inc | 2020-07-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details | |
| Luminol sodium | MP-1032 | Approved | Selvim, Metrio | Psoriasis; Immune System Diseases | null | 1997-01-01 | Immune System Diseases; Psoriasis | Details | ||
| Adalimumab biosimilar (Boehringer Ingelheim) | BI-695501 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Cyltezo | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Boehringer Ingelheim Gmbh | 2017-08-25 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Infliximab biosimilar (Amgen) | ABP-710 | Approved | Amgen Inc | Avsola | United States | Plaque psoriasis; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease | Amgen Inc | 2019-12-06 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Plaque psoriasis; Crohn Disease | Details |
| Adalimumab biosimilar (LG Life Sciences) | LBAL | Approved | Lg Chemical Ltd, Mochida Pharmaceutical Co Ltd | Japan | Behcet Syndrome; Uveitis, Intermediate; Uveitis, Posterior; Panuveitis; Crohn Disease; Colitis, Ulcerative; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis, Juvenile | Mochida Pharmaceutical Co Ltd | 2021-03-23 | Uveitis, Intermediate; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis, Posterior; Behcet Syndrome; Panuveitis; Crohn Disease | Details | |
| Adalimumab biosimilar (Celltrion) | CT-P17 | Approved | Celltrion | Yuflyma | EU | Crohn Disease; Uveitis; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Juvenile; Plaque psoriasis; Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Hidradenitis Suppurativa; Psoriasis; Spondylitis, Ankylosing | Celltrion Healthcare Hungary Kft | 2021-02-11 | Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Juvenile; Pediatric ulcerative colitis; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
| Infliximab biosimilar (Reliance Life Sciences) | BOW-015; R-TPR-015 | Approved | Epirus Biopharmaceuticals | Infimab | Arthritis, Rheumatoid | Details | ||||
| Etanercept biosimial (Sandoz) | GP-2015 | Approved | Clariant Produkte (Schweiz) Ag | Erelzi | EU | Arthritis, Juvenile; Plaque psoriasis; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Rheumatoid | Sandoz Gmbh | 2016-08-30 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Adalimumab biosimilar (Amgen) | ABP-501 | Approved | Amgen Inc | Amgevita, Amjevita, Solymbic | EU | Amgen Europe Bv | 2016-09-23 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease; Plaque psoriasis | Details | |
| Infliximab Biosimilar (Genor Biopharma) | GB-242 | Approved | Genor Biopharma Co Ltd | 佳佑健 | Mainland China | Spondylitis, Ankylosing; Crohn Disease; Psoriasis; Colitis, Ulcerative; Arthritis, Rheumatoid | Yuxi Genor Biotechnology Co Ltd | 2022-02-23 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Etanercept biosimilar (Hanwha Chemical) | HD-203; MK-8953 | Approved | Hanwha Chemical | Davictrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | ||||
| Infliximab | TA-650 | Approved | Janssen Global Services Llc | Remicade, 类克, Avakine, CenTNF | EU | Psoriasis | Janssen Biologics Bv | 1998-08-24 | Retinal Detachment; Psoriasis; Pediatric ulcerative colitis; Takayasu Arteritis; Breast Neoplasms; Vitreoretinopathy, Proliferative; Arthritis, Psoriatic; Colitis, Ulcerative; Aneurysm; Diabetic macular oedema; Parapsoriasis; Uveitis; Pulmonary Disease, Chronic Obstructive; Cachexia; Crohn Disease; Stevens-Johnson Syndrome; Behcet Syndrome; Diabetic Retinopathy; Spondylarthropathies; Inflammatory Bowel Diseases; Pancreatitis; Giant Cell Arteritis; Pediatric Crohn's disease; Bipolar Disorder; Vasculitis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Berylliosis; Graft vs Host Disease; Fatigue; Coronavirus Disease 2019 (COVID-19); Sarcoidosis; Mucocutaneous Lymph Node Syndrome; Stroke; Polymyalgia Rheumatica; Visual Acuity | Details |
| Thalidomide | NSC-66847; NSC-527179; K-17; VP-02 | Approved | Celgene Corp | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Japan | Leprosy, Lepromatous | Fujimoto Pharmaceutical | 1982-01-01 | Waldenstrom Macroglobulinemia; Sarcoma; Prostatic Neoplasms; Arachnoiditis; Cholangitis, Sclerosing; Gastrointestinal Hemorrhage; Osteosarcoma; Pancreatitis, Chronic; Retinoblastoma; Sarcoma, Ewing; Lymphoma, Mantle-Cell; Prostatitis; Colitis, Ulcerative; Colorectal Neoplasms; Neuroectodermal Tumors, Primitive; Erythema Nodosum; Leprosy, Lepromatous; Endometrial Neoplasms; Appendiceal Neoplasms; Pelvic Pain; Angiodysplasia; Glioma; Lymphoma, Non-Hodgkin; Carcinoma, Hepatocellular; Amyotrophic Lateral Sclerosis; Vascular Malformations; Crohn Disease; Precancerous Conditions; Mycobacterium avium-intracellulare Infection; Idiopathic Pulmonary Fibrosis; Leukemia; Lymphoma, B-Cell, Marginal Zone; Lymphoma, B-Cell; Liver Neoplasms; Cough; Telangiectasia, Hereditary Hemorrhagic; Mycobacterium Infections; Rhabdomyosarcoma; Arteriovenous Malformations; Inflammatory Bowel Diseases; Stomatitis, Aphthous; Gastric Antral Vascular Ectasia; Spondylitis, Ankylosing; Myelodysplastic Syndromes; HIV Infections; Coronavirus Dise | Details |
| Golimumab | CNTO-148; rTNV148B | Approved | Janssen Global Services Llc | Simponi, Simponi aria, Simponi/Simponi aria | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Janssen Biologics Bv | 2009-04-24 | Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Psoriatic; Asthma; Crohn Disease; Labyrinth Diseases | Details |
| Certolizumab pegol | PHA-738144; CDP-870; CZP | Approved | Ucb | Cimzia, Cimziat | Mainland China | Arthritis, Rheumatoid | Ucb Pharma Sa | 2008-04-22 | Infertility, Male; Polyarticular Juvenile Idiopathic Arthritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Spondylarthropathies; Spondylarthritis; Multiple Sclerosis; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Cystitis, Interstitial; Osteoarthritis, Spine; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab | D2E7; ABT-D2E7; LU-200134 | Approved | Abbvie Inc | 修美乐, Humira, Trudexa | EU | Psoriasis; Hidradenitis Suppurativa; Colitis, Ulcerative; Uveitis | Stada Arzneimittel Ag | 2002-12-31 | Arthritis; Glomerulosclerosis, Focal Segmental; Arthritis, Psoriatic; Colitis, Ulcerative; Cystitis, Interstitial; Osteoarthritis, Knee; Asthma; Hidradenitis Suppurativa; Uveitis; Sciatica; Mucositis; Osteoarthritis; Nephrotic Syndrome; Crohn Disease; Diabetic Retinopathy; Choroidal Neovascularization; Plaque psoriasis; Bursitis; Psoriasis; Nephrosis, Lipoid; Dupuytren Contracture; Arthritis, Juvenile; Pediatric Crohn's disease; Spondylarthritis; Pouchitis; Sarcoidosis; Coronavirus Disease 2019 (COVID-19); Spondylitis, Ankylosing; Arthritis, Rheumatoid; Giant Cell Arteritis; Pain; Inflammatory Bowel Diseases; Pyoderma Gangrenosum | Details |
| Etanercept | TNR-001 | Approved | Pfizer Pharmaceuticals Ltd (China), Amgen Inc | 恩利, Enbrel, Lifmior | Mainland China | Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid | C.H. Boehringer Sohn Ag & Co. Kg | 1998-11-02 | Hidradenitis Suppurativa; Prostatic Neoplasms; Asthma; Arthritis, Psoriatic; Lichen Planus; Alzheimer Disease; Bone Neoplasms; Arthritis; Inflammation; Fatigue Syndrome, Chronic; Myositis, Inclusion Body; Obesity; Lung Neoplasms; Plaque psoriasis; Neoplasm Metastasis; Kidney Failure, Chronic; Acute Lung Injury; Pemphigus; Vitiligo; Fanconi Anemia; HIV Infections; Diabetes Mellitus, Type 1; Bronchiolitis Obliterans; Leukemia; Lupus Erythematosus, Discoid; Chronic Urticaria; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Tinnitus; Synovitis; Graft vs Host Disease; Lupus Erythematosus, Cutaneous; Spondylarthritis; Pulmonary Fibrosis; Arthritis, Juvenile; Respiratory Distress Syndrome, Adult; Psoriasis | Details |
| Pomalidomide | IMID-4047; CDC-394; CC-4047; IMiD-1 | Approved | Celgene Corp | Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 | Mainland China | Multiple Myeloma | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2013-02-08 | Lung Diseases, Interstitial; Neoplasm Metastasis; Anemia, Sickle Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Sarcoma, Kaposi; Lymphoma, Non-Hodgkin; Primary Myelofibrosis; Amyloidosis; Sarcoma; Prostatic Neoplasms; Lymphoma, Follicular; Central Nervous System Neoplasms; Bone Marrow Neoplasms; Pulmonary Fibrosis; Multiple Myeloma; Graft vs Host Disease; Hodgkin Disease; Lymphoma, Large B-Cell, Diffuse; Scleroderma, Systemic; Neoplasms; Lymphoma, B-Cell; Medulloblastoma; Solid tumours | Details |
| Lenalidomide | CC-5013; IMiD-3; ENMD-0997; STAR-LLD; CDC-501; IMID-5013; CDC-5013 | Approved | Celgene Corp | Revimid (former Brand Name), 瑞复美, Revlimid, Leavdo | EU | Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular | Celgene Europe Bv | 2005-12-27 | Lymphoma, T-Cell, Cutaneous; Lymphoma, Follicular; Reflex Sympathetic Dystrophy; Radiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Histiocytosis, Langerhans-Cell; Prostatic Neoplasms; Demyelinating Diseases; Gliosarcoma; Primary Myelofibrosis; Histiocytic Sarcoma; Lymphoma, T-Cell; Lymphoma, Non-Hodgkin; Thrombocytopenia; Lymphoma; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Waldenstrom Macroglobulinemia; Thyroid Neoplasms; Glioma; Leukemia, Monocytic, Acute; Lymphoma, Large-Cell, Anaplastic; Carcinoma, Squamous Cell; Epstein-Barr Virus Infections; Cachexia; Leukemia, Lymphocytic, Chronic, B-Cell; Crohn Disease; Melanoma; Complex Regional Pain Syndromes; Neoplasm Metastasis; Carcinoma, Non-Small-Cell Lung; Mental Disorders; Neoplasms; Lymphoma, B-Cell, Marginal Zone; HIV Infections; Lymphoma, T-Cell, Peripheral; Lymphoma, B-Cell; Liver Neoplasms; Leukemia; Leukemia, Myeloid; Bone Marrow Neoplasms; Leukemia, Erythroblastic, Acute; Hematologic Diseases; Anemia; Paraproteinemias; Pain; Myelodys | Details |
| Adalimumab biosimilar (Sandoz) | GP-2017 | Approved | Sandoz | Hefiya, Hyrimoz, Halimatoz | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Sandoz Inc | 2018-07-26 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease | Details |
| Adalimumab biosimilar (Fresenius Kabi) | MSB-11022 | Approved | Merck Serono, Fresenius Kabi Ag | Idacio, Kromeya | EU | Psoriasis; Hidradenitis Suppurativa; Colitis, Ulcerative; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease | Fresenius Kabi Deutschland Gmbh | 2019-04-02 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Adalimumab biosimilar (CinnaGen) | Phase 3 Clinical | Cinnagen | Arthritis, Rheumatoid | Details | |
| Recombinant human anti-TNFα monoclonal antibody (Huaota Biopharma) | Phase 3 Clinical | Shanghai Huaota Biopharmaceutical Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis; Plaque psoriasis | Details | |
| Certolizumab (Intrexon) | AG-014 | Phase 1 Clinical | Intrexon Co | Inflammatory Bowel Diseases | Details |
| XTMAB-16 | XTMAB-16 | Phase 1 Clinical | Xentria Inc | Sarcoidosis | Details |
| Adalimumab biosimilar (AXXO) | Clinical | Axxo | Arthritis, Rheumatoid; Arthritis, Psoriatic | Details | |
| IBPM005IX (Inbiopro Solutions) | Clinical | Inbiopro Solutions | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic; Crohn Disease | Details | |
| Etanercept (Neurokine Pharmaceuticals) | NP-1; NK-001 | Clinical | Pivot Pharmaceuticals | Cognition Disorders | Details |
| Anti-tumour necrosis factor alpha (Livzon) | Phase 1 Clinical | Livzon Pharmaceutical Group Inc | Autoimmune Diseases | Details | |
| Adalimumab biosimilar (Hetero Drugs) | Phase 3 Clinical | Hetero Drugs | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Oncobiologics) | ONS-3010 | Phase 3 Clinical | Outlook Therapeutics | Psoriasis | Details |
| Adalimumab biosimilar (Danhong Pharma) | BC-002 | Phase 3 Clinical | Shandong Danhong Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Hualan Biological Engineering) | Phase 3 Clinical | Hualan Genetic Engineering Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis | Details | |
| Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) | Phase 3 Clinical | Tonghua Dongbao Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Plaque psoriasis | Details | |
| Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) | Phase 3 Clinical | Wuhan Institute Of Biological Products Co Ltd | Plaque psoriasis | Details | |
| JNJ-63823539 | JNJ-63823539 | Phase 1 Clinical | Janssen Global Services Llc | Arthritis, Rheumatoid | Details |
| ND-009 | ND-009 | Phase 1 Clinical | Numab Therapeutics Ag, Tillotts Pharma Ag | Inflammation | Details |
| SAR-442970 | SAR-442970 | Phase 1 Clinical | Sanofi | Inflammation | Details |
| Adalimumab biosimilar (Weimingdamu Biotech) | Phase 1 Clinical | Anhui Weiming Damu Biomedicine Co Ltd | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar(BioXpress) | BX-2922; BXT-2922 | Clinical | Bioxpress Therapeutics Sa | Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Rheumatoid; Arthritis, Juvenile; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Adalimumab biosimillar(Huabo) | Onco-3010; HOT-3010 | Phase 3 Clinical | Huabo Biopharm Co Ltd | Arthritis, Rheumatoid | Details |
| Infliximab biosimilar (Ospedale San Raffaele) | Phase 1 Clinical | Ospedale San Raffaele | Takayasu Arteritis | Details | |
| Recombinant anti-TNFα monoclonal antibody (Livzon Group) | AT-132; LZM-001 | Phase 2 Clinical | Livzon Pharmaceutical Group Inc | Arthritis, Rheumatoid | Details |
| Wogonin | Phase 1 Clinical | Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University | Respiratory Tract Infections; Neoplasms | Details | |
| Etanercept biosimilar (Clover Biopharmaceuticals) | SCB-808 | Phase 3 Clinical | Sichuan Sanyecao Bio-Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Thrombocytopenia | Details |
| ABBV-257 | DVD-1; ABBV-257; DVD-Ig-1 | Abbott Laoratories | Details | ||
| HMPL-004 (Hutchison Medipharma) | HMPL-004 | Hutchison Medipharma Ltd | Details | ||
| Infliximab biosimilar (Biocad) | BCD-055 | Biocad | Details | ||
| Tumour necrosis factor alpha kinoid | TNF-K; TNF-K005 | Neovacs | Details | ||
| Monoclonal Antibody (Mab) sB24M | Phase 1 Clinical | Pyoderma Gangrenosum | Details | ||
| ME-3183 | ME-3183 | Phase 1 Clinical | Meiji Seika Pharma Co Ltd | Psoriasis | Details |
| Isomyosamine | MYMD-1 | Phase 2 Clinical | Mymd Pharmaceuticals Inc | Healthy Aging | Details |
| Adalimumab biosimilar(Incepta) | Phase 3 Clinical | Incepta Pharmaceuticals Ltd | Arthritis, Rheumatoid | Details | |
| IA-14069 | IA-14069 | ILAb Co Ltd | Details | ||
| Ozoralizumab | TS-152; ATN-103; PF-5230896; PF-05230896 | Ablynx | Details | ||
| JNJ-61178104 | JNJ-61178104 | Phase 1 Clinical | Janssen Global Services Llc | Autoimmune Diseases | Details |
| V-565 | V-565 | Vhsquared | Details | ||
| CC-11050 | CC-11050 | Celgene Corp | Details | ||
| COVA-322 | COVA-322 | Covagen | Details | ||
| EYS-606 | EYS-606 | Eyevensys | Details | ||
| Golimumab biosimilar (Bio-thera) | BAT-2506 | Phase 3 Clinical | Bio-Thera Solutions Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Arthritis | Details |
| Etanercept biosimilar (Coherus Biosciences) | CHS-0214; BAX-2200 | Coherus Biosciences Inc | Details | ||
| CC-10015 | CC-10015 | Celgene Corp | Details | ||
| Doramapimod | BIRB-796-BS; BIRB-0796; BIRB-796; BIBR-796 | C.H. Boehringer Sohn Ag & Co. Kg | Details | ||
| AVX-470 | AVX-470; AVX-1350; AVX-470h | Avaxia Biologics | Details | ||
| Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 1 Clinical | Oncoimmune | Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19) | Details |
| Hemay007 | Hemay-007 | Phase 2 Clinical | Tianjin Hemay Bio-Tech Co Ltd | Arthritis, Rheumatoid; Colitis, Ulcerative | Details |
| LY-3114062 | LY3114062; LY-3114062 | Eli Lilly And Company | Details | ||
| Tanfanercept | HBM-9036; HL-036 | Phase 3 Clinical | Hanall | Dry Eye Syndromes; Xerophthalmia | Details |
| Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) | Phase 1 Clinical | Qilu Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | |
| Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) | Phase 1 Clinical | Shanghai Harmony Pharmaceutical Technology Co Ltd | Details | ||
| Adalimumab biosimilar (DZM Biotech) | Phase 1 Clinical | Dzm Biotech Ltd | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Genor Biopharma) | GB-232; BCD-100 | Phase 2 Clinical | Genor Biopharma Co Ltd | Carcinoma, Renal Cell; Arthritis, Rheumatoid; Lung Neoplasms; Melanoma | Details |
| PM-1016 | PM1016; TILT-123 | Phase 2 Clinical | Tilt Biotherapeutics Ltd | Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Melanoma | Details |
| Etanercept biosimilar (Suzhou Genemen Biotech) | BF-02; GM-02 | Phase 1 Clinical | Suzhou Genemen Biotech Co Ltd | Spondylitis, Ankylosing | Details |
| Adalimumab biosimilar (Prestige BioPharma) | PBP-1502 | Phase 1 Clinical | Prestige Biopharma | Details | |
| Adalimumab biosimilar (Alphamab) | KN-002 | Phase 1 Clinical | Suzhou Alphamab Co Ltd | Arthritis, Rheumatoid; Asthma | Details |
| Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) | Phase 1 Clinical | North China Pharmaceutical Company Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details | |
| Guselkumab/Golimumab | JNJ-78934804 | Phase 2 Clinical | Janssen Research & Development Llc | Colitis, Ulcerative; Crohn Disease | Details |
| Hemay-005 | Hemay-005 | Phase 3 Clinical | Hainan Hailing Chemipharma Corporation Ltd, Tianjin Hemay Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Pulmonary Disease, Chronic Obstructive; Behcet Syndrome; Dermatitis, Atopic; Plaque psoriasis | Details |
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