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| Project item | Indications | Research phase | Cooperation demands |
| BHE202204 | Idiopathic Pulmonary Fibrosis (IPF) | Phase 2 | License-out or co-development |
GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) induces cytotoxicity effect on the WEHI-13VAR cells in the presence of the metabolic inhibitor actinomycin D. The specific activity GMP Human TNF-alpha Protein (Cat. No. GMP-TNAH23) is ≥ 2.0×10^7 IU/mg , which is calibrated against human TNF-alpha WHO International Standard (NIBSC code: 12/154) (QC tested).
Biotinylated Monoclonal Anti-TNF-alpha Antibody, human IgG1 (16H5) (Cat. No. TNA-BLM494) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 75.9 pM as determined in a SPR assay (Biacore 8K) (Routinely tested).
Monoclonal Anti-TNF-alpha antibody, Human IgG1 (13B8) (Cat. No. TNA-AM493) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind Human TNF-alpha, His Tag (Cat. No. TNA-H5228) with an affinity constant of 0.133 nM as determined in a SPR assay (Biacore 8K) (Routly tested).
| Name | Research Code | Research Phase | Company | First Brand Name | First Approved Country | First Indication | First Approved Company | First Approved Date | Indications | Clinical Trials |
|---|---|---|---|---|---|---|---|---|---|---|
| Adalimumab biosimilar (Hisun Pharma) | HS-016 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | 安健宁 | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Hisun Biopharmaceutical Co Ltd | 2019-12-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Luminol sodium | MP-1032 | Approved | Selvim, Metrio | Psoriasis; Immune System Diseases | null | 1997-01-01 | Coronavirus Disease 2019 (COVID-19); Immune System Diseases; Psoriasis | Details | ||
| Infliximab biosimilar (Hisun Pharma) | HS-626 | Approved | Zhejiang Hisun Pharmaceutical Co Ltd | Mainland China | Psoriasis | Hisun Biopharmaceutical Co Ltd | 2021-09-24 | Psoriasis | Details | |
| Opinercept | E-11; ENIA-11 | Approved | Tsh Biopharm, Mycenax Biotech Inc | TuNEX | Taiwan | Arthritis, Rheumatoid | null | 2017-01-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals) | Approved | Hisun-Pfizer | AnBaiNuo | Mainland China | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis | Wyeth Europa Ltd | 2010-02-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | |
| Infliximab biosimilar (Bionovis/The Instituto Vital Brazil) | Approved | Bionovis, The Instituto Vital Brazil | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Details | ||||||
| Pomalidomide | IMID-4047; CDC-394; CC-4047; IMiD-1 | Approved | Pomalyst, Imnovid, Actimid, Pomalyst/Imnovid, 安跃 | United States | Multiple Myeloma | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2013-02-08 | Pulmonary Fibrosis; Anemia, Sickle Cell; Atypical Squamous Cells of the Cervix; Neurofibromatosis 1; Sarcoma, Kaposi; Lymphoma, Non-Hodgkin; Carcinoma, Small Cell; Glioma; Waldenstrom Macroglobulinemia; Primary Myelofibrosis; Sarcoma; Prostatic Neoplasms; Thrombocytosis; Lung Diseases, Interstitial; Solid tumours; Central Nervous System Neoplasms; Multiple Myeloma; Hodgkin Disease; Scleroderma, Systemic; Pancreatic Neoplasms; Kidney Diseases; Immunoglobulin Light-chain Amyloidosis; Graft vs Host Disease; Myeloproliferative Disorders; Plasmacytoma; Polycythemia Vera; Medulloblastoma; Bone Marrow Neoplasms | Details | |
| Certolizumab pegol | PHA-738144; CDP-870; CZP | Approved | Ucb | 希敏佳, Cimzia, Cimziat | United States | Arthritis, Rheumatoid | Ucb Pharma Sa | 2008-04-22 | Polyarticular Juvenile Idiopathic Arthritis; Infertility, Male; Spondylitis, Ankylosing; Spondylarthritis; Arthritis, Rheumatoid; Spondylarthropathies; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Cystitis, Interstitial; Osteoarthritis, Spine; Crohn Disease; Plaque psoriasis | Details |
| Etanercept biosimilar (Intas Biopharmaceuticals) | Approved | Intas Biopharmaceuticals | Intacept | India | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis | Intas Biopharmaceuticals | 2015-03-01 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |
| Anti-tumour necrosis factor-alpha antibody | Approved | Materia Medica Holding Research And Production Company | Artrofoon, Arthrofoon | Arthritis, Rheumatoid; Osteoarthritis | Details | |||||
| Etanercept biosimilar (AryoGen Biopharma) | Approved | Aryogen Biopharma | Altebrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details | |||||
| Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan) | FKB-327 | Approved | Fujifilm Kyowa Kirin Biologics Co Ltd | Hulio | EU | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic | Viatris Ltd | 2018-09-16 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Adalimumab biosimilar (Biocad) | BCD-057 | Approved | Biocad | Russian Federation | Psoriasis | Biocad | 2019-03-01 | Psoriasis | Details | |
| Etanercept biosimilar (Nanogen Biopharmaceutical) | Approved | Nanogen Biopharmaceutical Co | Nanercept | Vietnam | Psoriasis; Arthritis, Rheumatoid | Nanogen Biopharmaceutical Co | 2019-01-01 | Arthritis, Rheumatoid; Psoriasis | Details | |
| Adalimumab biosimilar (Celltrion) | CT-P17 | Approved | Celltrion Inc | Yuflyma | EU | Arthritis, Rheumatoid; Colitis, Ulcerative; Hidradenitis Suppurativa; Psoriasis; Spondylitis, Ankylosing; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Juvenile; Plaque psoriasis; Crohn Disease; Uveitis; Arthritis, Psoriatic | Celltrion Healthcare Hungary Kft | 2021-02-11 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis; Crohn Disease | Details |
| Etanercept biosimilar (PROBIOMED) | Approved | Probiomed | Infinitam | Mexico | Arthritis, Rheumatoid | Probiomed | 2014-01-01 | Arthritis, Rheumatoid | Details | |
| Adalimumab biosimilar (Coherus BioSciences) | CHS-1420 | Approved | Coherus Biosciences Inc | Yusimry | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Crohn Disease; Plaque psoriasis; Colitis, Ulcerative | Coherus Biosciences Inc | 2021-12-17 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Boehringer Ingelheim) | BI-695501 | Approved | C.H. Boehringer Sohn Ag & Co. Kg | Cyltezo | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Boehringer Ingelheim Gmbh | 2017-08-25 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis; Hidradenitis Suppurativa; Crohn Disease | Details |
| Edaravone/(+)-2-Decanol | SIM-071201; Y-2 | Approved | Jiangsu Simcere Pharmaceutical Co Ltd | Mainland China | Stroke | Nanjing Simcere Dongyuan Pharmaceutical Co Ltd | 2020-07-29 | Brain Infarction; Intracranial Hemorrhages; Cerebral Hemorrhage; Stroke; Alzheimer Disease; Amyotrophic Lateral Sclerosis | Details | |
| Adalimumab biosimilar (Pfizer) | PF-06410293 | Approved | Pfizer Pharmaceuticals Ltd (China) | Amsparity, Abrilada, Fyzoclad | United States | Arthritis, Psoriatic; Hidradenitis Suppurativa; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Uveitis; Psoriasis | Pfizer Europe Ma Eeig | 2019-11-15 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Innovent Biologics) | IBI-303 | Approved | Innovent Biologics(Suzhou) Co Ltd | 苏立信 | Mainland China | Crohn Disease; Pediatric Crohn's disease | Innovent Biologics(Suzhou) Co Ltd | 2020-09-02 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Reliance Life Sciences) | R-TPR-021 | Approved | Reliance Life Sciences | Adfrar IB | India | Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic | Reliance Life Sciences, Torrent Pharma | 2016-01-12 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic | Details |
| Infliximab biosimilar (AXXO) | Approved | Axxo | Russian Federation | Crohn Disease; Autoimmune Diseases | Axxo | 2013-01-01 | Autoimmune Diseases; Crohn Disease | Details | ||
| Etanercept biosimial (Sandoz) | GP-2015 | Approved | Clariant Produkte (Schweiz) Ag | Erelzi | United States | Plaque psoriasis; Arthritis, Juvenile; Spondylitis, Ankylosing; Arthritis, Psoriatic; Arthritis, Rheumatoid | Sandoz Gmbh | 2016-08-30 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Adalimumab biosimilar (Bio-Thera Solutions) | BAT-1406 | Approved | Bio-Thera Solutions Ltd | 格乐立 | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Uveitis; Psoriasis | Bio-Thera Solutions Ltd | 2019-11-04 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Zydus Cadila) | ZRC-3197 | Approved | Zydus Cadila | Exemptia, Adaly | India | Arthritis, Juvenile; Arthritis, Rheumatoid; Arthritis, Psoriatic; Spondylitis, Ankylosing | Zydus Cadila | 2014-12-09 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic | Details |
| Adalimumab biosimilar (Mylan/Biocon) | BMO-2; MYL-1401-A | Approved | Biocon Ltd | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Mylan Pharmaceuticals Inc | 2020-07-06 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details | |
| Etanercept biosimilar (Hanwha Chemical) | HD-203; MK-8953 | Approved | Hanwha Chemical | Davictrel | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic | Details | ||||
| Etanercept biosimilar (Mochida) | LBEC-0101 | Approved | Mochida Pharmaceutical Co Ltd | Japan | Arthritis, Juvenile; Arthritis, Rheumatoid | null | 2018-01-19 | Arthritis, Rheumatoid; Arthritis, Juvenile | Details | |
| Infliximab biosimilar (Amgen) | ABP-710 | Approved | Amgen Inc | Avsola | United States | Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Amgen Inc | 2019-12-06 | Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylitis, Ankylosing; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details |
| PG-201 | PG-201 | Approved | Viromed | Layla | South Korea | Osteoarthritis | Pmg Pharm Co Ltd | 2012-01-01 | Osteoarthritis, Knee; Osteoarthritis | Details |
| Infliximab Biosimilar (Genor Biopharma) | GB-242 | Approved | Genor Biopharma Co Ltd | 佳佑健 | Mainland China | Colitis, Ulcerative; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Crohn Disease; Psoriasis | Yuxi Genor Biotechnology Co Ltd | 2022-02-23 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Thalidomide | NSC-66847; NSC-527179; K-17; VP-02 | Approved | Talizer, Thalidomide Celgene, Thalidomide Pharmion, Synovir, Thalomid, Thaled | Mainland China | Leprosy, Lepromatous | Fujimoto Pharmaceutical | 1982-01-01 | Osteosarcoma; Leprosy, Lepromatous; Drug Resistant Epilepsy; Primary Myelofibrosis; Neuroectodermal Tumors, Primitive; Prostatitis; Colorectal Neoplasms; Lymphoma, Mantle-Cell; Sarcoma, Ewing; Retinoblastoma; Waldenstrom Macroglobulinemia; Cholangitis, Sclerosing; HIV Wasting Syndrome; Arachnoiditis; Adenocarcinoma, Clear Cell; Prostatic Neoplasms; Pancreatitis, Chronic; Lymphoma, Follicular; Sarcoma; Xerostomia; Burning Mouth Syndrome; Neoplasm Metastasis; Mycobacterium avium-intracellulare Infection; Vascular Malformations; Amyotrophic Lateral Sclerosis; Melanoma; Carcinoma, Hepatocellular; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic-Myeloproliferative Diseases; Stomatitis; Erythema Nodosum; Anemia, Sideroblastic; Uterine Neoplasms; Lymphoma, Non-Hodgkin; Glioma; Angiodysplasia; Pelvic Pain; Appendiceal Neoplasms; Lung Neoplasms; Endometrial Neoplasms; Mycobacterium Infections; Gastric Antral Vascular Ectasia; Carcinoid Tumor; Lupus Erythematosus, Discoid; Stomatitis, Aphthous; Rhabdomyosarcoma; | Details | |
| Adalimumab biosimilar (LG Life Sciences) | LBAL | Approved | Lg Chemical Ltd, Mochida Pharmaceutical Co Ltd | Japan | Behcet Syndrome; Uveitis, Intermediate; Uveitis, Posterior; Panuveitis; Crohn Disease; Colitis, Ulcerative; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis, Juvenile | Mochida Pharmaceutical Co Ltd | 2021-03-23 | Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Uveitis, Posterior; Behcet Syndrome; Panuveitis; Crohn Disease | Details | |
| Etanercept biosimilar (Amega Biotech) | Approved | Amega Biotech | Enerceptan | Argentina | Arthritis, Rheumatoid | Amega Biotech | 2012-01-01 | Arthritis, Rheumatoid | Details | |
| Etanercept biosimilar (Mylan) | YLB-113 | Approved | Rubin Ltd, Mylan Nv | Nepexto | EU | Arthritis, Juvenile; Plaque psoriasis; Arthritis, Rheumatoid; Spondylarthropathies; Arthritis, Psoriatic; Spondylitis, Ankylosing | Mylan Ire Healthcare Ltd | 2020-05-20 | Arthritis, Rheumatoid; Spondylarthropathies; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Plaque psoriasis | Details |
| Golimumab | CNTO-148; rTNV148B | Approved | Janssen Global Services Llc | Simponi, Simponi aria, Simponi/Simponi aria | United States | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Janssen Biologics Bv | 2009-04-24 | Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Colitis, Ulcerative; Arthritis, Psoriatic; Asthma; Crohn Disease; Labyrinth Diseases | Details |
| Adalimumab biosimilar (Amgen) | ABP-501 | Approved | Amgen Inc | Amgevita, Amjevita, Solymbic | United States | Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Amgen Inc | 2016-09-23 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Pediatric ulcerative colitis; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
| Infliximab biosimilar (Nichiiko/Aprogen) | NI-071; GS-071; GS-07; AP-07 | Approved | Nichi-Iko Pharmaceutical Co Ltd, Aprogen | Japan | Arthritis, Psoriatic; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis | Nichi-Iko Pharmaceutical Co Ltd | 2017-09-27 | Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | |
| Adalimumab biosimilar (CTTQ Pharma) | Approved | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | Mainland China | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Jiangsu Chia Tai-Tianqing Pharmaceutical Co Ltd | 2022-01-18 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease | Details | ||
| Etanercept | TNR-001 | Approved | Pfizer Pharmaceuticals Ltd (China), Amgen Inc | 恩利, Enbrel, Lifmior | United States | Arthritis, Psoriatic; Arthritis, Juvenile; Arthritis, Rheumatoid; Psoriasis; Plaque psoriasis | Immunex | 1998-11-02 | Cachexia; Psoriasis; Myositis, Inclusion Body; Prostatic Neoplasms; Asthma; Alzheimer Disease; Arthritis, Psoriatic; Lichen Planus; Bone Neoplasms; Inflammation; Uveitis; Respiratory Distress Syndrome, Adult; Arthritis; Obesity; Hidradenitis Suppurativa; Lung Neoplasms; Stomatitis; Plaque psoriasis; Neoplasm Metastasis; Acute Lung Injury; Kidney Failure, Chronic; Vitiligo; Lupus Erythematosus, Cutaneous; Diabetes Mellitus, Type 1; HIV Infections; Tinnitus; Solid tumours; Bronchiolitis Obliterans; Leukemia; Lupus Erythematosus, Discoid; Arthritis, Rheumatoid; Metabolic Syndrome; Vasculitis; Granulomatosis with Polyangiitis; Spondylarthritis; Spondylitis, Ankylosing; Synovitis; Sjogren's Syndrome; Chronic Urticaria; Anorexia; Fanconi Anemia; Graft vs Host Disease; Arthritis, Juvenile; Pulmonary Fibrosis | Details |
| Infliximab | TA-650 | Approved | Janssen Global Services Llc | Remicade, 类克, Avakine, CenTNF | United States | Arthritis, Rheumatoid; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Centocor | 1998-08-24 | Parapsoriasis; Diabetic macular oedema; Psoriasis; Pediatric ulcerative colitis; Vitreoretinopathy, Proliferative; Glaucoma; Arthritis, Psoriatic; Colitis, Ulcerative; Aneurysm; Retinal Detachment; Visual Acuity; Uveitis; Hidradenitis Suppurativa; Granulomatous Disease, Chronic; Pulmonary Disease, Chronic Obstructive; Crohn Disease; Stevens-Johnson Syndrome; Behcet Syndrome; Diabetic Retinopathy; Melanoma; Spondylitis, Ankylosing; Inflammatory Bowel Diseases; Pancreatitis; Macular Edema; Scleritis; Giant Cell Arteritis; Dermatomyositis; Coronavirus Disease 2019 (COVID-19); Pediatric Crohn's disease; Vasculitis; Polymyositis; Arthritis, Rheumatoid; Spondylarthropathies; Graft vs Host Disease; Bipolar Disorder; Sarcoidosis; Mucocutaneous Lymph Node Syndrome; Stroke; Polymyalgia Rheumatica; Arthritis, Juvenile | Details |
| Lenalidomide | IMID-5013; CDC-5013; CDC-501; CC-5013; IMiD-3; ENMD-0997; STAR-LLD | Approved | Celgene Corp | Leavdo, Revimid (former Brand Name), 瑞复美, Revlimid | United States | Myelodysplastic Syndromes | Celgene Corp | 2005-12-27 | Liver Neoplasms; Hematologic Diseases; Optic Nerve Glioma; Leukemia, Myeloid; Immunoproliferative Small Intestinal Disease; Leukemia; Leukemia, Erythroblastic, Acute; Ependymoma; Lymphoma, T-Cell, Peripheral; Solid tumours; Kidney Neoplasms; Lymphoma, B-Cell, Marginal Zone; Bone Marrow Neoplasms; Ovarian Neoplasms; Medulloblastoma; Intestinal Neoplasms; Leukemia, Promyelocytic, Acute; HIV Infections; Anemia; Plaque, Amyloid; Rhabdoid Tumor; Leukemia, Hairy Cell; Pain; Paraproteinemias; Anemia, Refractory, with Excess of Blasts; Polycythemia Vera; Lymphoma, Large B-Cell, Diffuse; Leukemia-Lymphoma, Adult T-Cell; Myelodysplastic Syndromes; Neoplasms; Nerve Degeneration; Glioblastoma; Plasmacytoma; Hodgkin Disease; Lymphomatoid Granulomatosis; Blood Protein Disorders; Pancreatic Neoplasms; Smoldering Multiple Myeloma; Anemia, Refractory; Graft vs Host Disease; Leukemia, Myelomonocytic, Acute; Myeloproliferative Disorders; Hypothalamic Neoplasms; Leukemia, Myelomonocytic, Chronic; Multiple Myeloma; Leukemia, Mega | Details |
| Etanercept biosimilar (Samsung Bioepis) | SB-4 | Approved | Samsung Bioepis Co Ltd | Eticovo, Benepali | EU | Arthritis, Psoriatic; Arthritis, Rheumatoid | Samsung Bioepis Nl Bv | 2016-01-13 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic | Details |
| Adalimumab | ABT-D2E7; LU-200134; D2E7 | Approved | Abbvie Inc | Humira, Trudexa, 修美乐 | United States | Arthritis, Rheumatoid | Abbvie Inc | 2002-12-31 | Uveitis, Posterior; Colitis, Ulcerative; Cystitis, Interstitial; Arthritis, Psoriatic; Osteoarthritis, Knee; Asthma; Hidradenitis Suppurativa; Uveitis; Arthritis; Glomerulosclerosis, Focal Segmental; Mucopolysaccharidosis II; Nephrotic Syndrome; Osteoarthritis; Crohn Disease; Plaque psoriasis; Diabetic Retinopathy; Choroidal Neovascularization; Panuveitis; Pouchitis; Pyoderma Gangrenosum; Pain; Uveitis, Intermediate; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric Crohn's disease; Spondylarthritis; Sarcoidosis; Bursitis; Coronavirus Disease 2019 (COVID-19); Arthritis, Juvenile; Mucopolysaccharidosis I; Nephrosis, Lipoid; Dupuytren Contracture; Psoriasis; Mucopolysaccharidosis VI | Details |
| Infliximab biosimilar (Merck & Co/Samsung Bioepis) | SB-2 | Approved | Samsung Bioepis Co Ltd, Merck & Co Inc | Renflexis, Flixabi | EU | Arthritis, Psoriatic; Crohn Disease; Psoriasis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative | Samsung Bioepis Nl Bv | 2016-05-26 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Plaque psoriasis | Details |
| Ozoralizumab | PF-5230896; ATN-103; PF-05230896; TS-152 | Approved | Ablynx Nv | ナノゾラ, Nanozora | Japan | Arthritis, Rheumatoid | Taisho Pharmaceutical Co Ltd | 2022-09-26 | Arthritis, Rheumatoid | Details |
| Infliximab biosimilar (Celltrion) | CT-P13 | Approved | Celltrion Inc | Remsima, Inflectra, Inflectra/Remsima, Flammegis | EU | Crohn Disease; Psoriasis; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative | Celltrion Healthcare Hungary Kft | 2013-09-10 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Urologic Neoplasms; Hidradenitis Suppurativa; Crohn Disease | Details |
| Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical) | 301S | Approved | Sunshine Guojian Pharmaceutical (Shanghai) Co Ltd, Cipla Gmbh | Yisaipu, Etacept, 益赛普, Etanar | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Sunshine Guojian Pharmaceutical (Shanghai) Co Ltd | 2005-06-20 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details |
| Adalimumab biosimilar (Jiangsu Zhonghe/Shanghai Junshi/Jiangsu T-Mab) | UBP-1211; 9MW0113; 9-MW-0113; 9-MW0113; 9MW-0113 | Approved | Jiangsu Zhonghe Pharmaceutical Technology Co Ltd, Jiangsu T-Mab Bio-Pharmaceuticals Co Ltd, Mabwell (Shanghai) Bioscience Co Ltd | 君迈康 | Mainland China | Spondylitis, Ankylosing; Psoriasis; Arthritis, Rheumatoid | Shanghai Junshi Biosciences Co Ltd | 2022-03-01 | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Pediatric Crohn's disease; Arthritis, Juvenile; Psoriasis; Uveitis; Crohn Disease | Details |
| Adalimumab biosimilar (Samsung Bioepis) | SB-5 | Approved | Samsung Bioepis Co Ltd | Imraldi, Hadlima | EU | Psoriasis; Pediatric ulcerative colitis; Pediatric Crohn's disease; Arthritis, Juvenile; Plaque psoriasis; Uveitis; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease | Samsung Bioepis Nl Bv | 2017-08-24 | Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Pediatric ulcerative colitis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Plaque psoriasis; Crohn Disease | Details |
| Infliximab biosimilar (Shanghai Biomabs) | CMAB-008; STI-002 | Approved | Shanghai Biomabs Pharmaceuticals Co Ltd | 百类停, 类停 | Mainland China | Pediatric Crohn's disease; Crohn Disease; Spondylitis, Ankylosing; Colitis, Ulcerative; Psoriasis; Arthritis, Rheumatoid | Taizhou Mabtech Pharmaceutical Co Ltd | 2021-07-12 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Crohn Disease | Details |
| Adalimumab biosimilar (Shanghai Henlius Biotech) | HLX-03 | Approved | Shanghai Henlius Biotech Inc | 汉达远 | Mainland China | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Shanghai Henlius Biotech Inc | 2020-12-02 | Uveitis, Intermediate; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Immune System Diseases; Psoriasis; Uveitis, Posterior; Plaque psoriasis; Panuveitis | Details |
| Adalimumab biosimilar (Alvotech) | AVT-02 (Alvotech) | Approved | Alvotech hf | HUKYNDRA, LIBMYRIS, SIMLANDI, SIMLANDITM | EU | Colitis, Ulcerative; Hidradenitis Suppurativa; Arthritis, Psoriatic; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Crohn Disease; Uveitis; Psoriasis | Stada Arzneimittel Ag | 2021-11-12 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Infliximab biosimilar (Pfizer) | PF-6438179; GP-1111; PF-06438179 | Approved | Pfizer Inc | Ixifi, Zessly | EU | Pediatric Crohn's disease; Pediatric ulcerative colitis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Colitis, Ulcerative; Crohn Disease; Psoriasis; Arthritis, Psoriatic | Pfizer Europe Ma Eeig | 2013-09-09 | Pediatric Crohn's disease; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Pediatric ulcerative colitis; Psoriasis; Colitis, Ulcerative; Arthritis, Psoriatic; Crohn Disease | Details |
| Infliximab biosimilar (Reliance Life Sciences) | BOW-015; R-TPR-015 | Approved | Epirus Biopharmaceuticals Inc | Infimab | Arthritis, Rheumatoid | Details | ||||
| Adalimumab biosimilar (Fresenius Kabi) | MSB-11022 | Approved | Merck Serono | Idacio, Kromeya | EU | Arthritis, Psoriatic; Psoriasis; Hidradenitis Suppurativa; Colitis, Ulcerative | Fresenius Kabi Deutschland Gmbh | 2019-04-02 | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Uveitis; Hidradenitis Suppurativa; Crohn Disease; Plaque psoriasis | Details |
| Adalimumab biosimilar (Sandoz) | GP-2017 | Approved | Sandoz | Hefiya, Hyrimoz, Halimatoz | EU | Hidradenitis Suppurativa; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Non-radiographic axial spondyloarthritis; Plaque psoriasis; Polyarticular Juvenile Idiopathic Arthritis; Colitis, Ulcerative; Crohn Disease; Arthritis, Juvenile; Psoriasis | Sandoz Gmbh | 2018-07-26 | Non-radiographic axial spondyloarthritis; Polyarticular Juvenile Idiopathic Arthritis; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Plaque psoriasis; Crohn Disease | Details |
| Name | Research Code | Research Phase | Company | Indications | Clinical Trials |
|---|---|---|---|---|---|
| Isomyosamine | MYMD-1 | Phase 2 Clinical | Mymd Pharmaceuticals Inc | Depression; Anxiety; Hashimoto Disease; Coronavirus Disease 2019 (COVID-19); Healthy Aging; Inflammation | Details |
| Adalimumab biosimilar (CinnaGen) | Phase 3 Clinical | Cinnagen | Arthritis, Rheumatoid | Details | |
| ME-3183 | ME-3183 | Phase 2 Clinical | Meiji Seika Pharma Co Ltd | Psoriasis | Details |
| Hemay007 | Hemay-007 | Phase 2 Clinical | Tianjin Hemay Bio-Tech Co Ltd | Inflammatory Bowel Diseases; Arthritis, Rheumatoid; Colitis, Ulcerative | Details |
| Monoclonal Antibody (Mab) sB24M | Phase 1 Clinical | Swiss Biopharma Med GmbH | Pyoderma Gangrenosum; Pyoderma | Details | |
| Adalimumab biobetter(Xencor/Zenas Biopharma) | XmAb-6755; ZB-002 | Phase 1 Clinical | Xencor Inc, Zenas BioPharma | Autoimmune Diseases of the Nervous System | Details |
| Certolizumab (Intrexon) | AG-014 | Phase 1 Clinical | Intrexon Corporation | Inflammatory Bowel Diseases | Details |
| IA-14069 | IA-14069 | Phase 1 Clinical | ILAb Co Ltd | Arthritis, Rheumatoid | Details |
| XTMAB-16 | XTMAB-16 | Phase 1 Clinical | Xentria Inc | Sarcoidosis | Details |
| Adalimumab biosimilar(BioXpress) | BX-2922; BXT-2922 | Clinical | Bioxpress Therapeutics Sa | Pediatric Crohn's disease; Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Juvenile; Arthritis, Psoriatic; Colitis, Ulcerative; Hidradenitis Suppurativa; Uveitis; Crohn Disease | Details |
| Recombinant anti-TNFα monoclonal antibody (Livzon Group) | AT-132; LZM-001 | Phase 2 Clinical | Livzon Pharmaceutical Group Inc | Arthritis, Rheumatoid | Details |
| Adalimumab biosimilar (Hualan Biological Engineering) | Phase 3 Clinical | Hualan Genetic Engineering Co Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis | Details | |
| Adalimumab biosimilar (AXXO) | Clinical | Axxo | Arthritis, Rheumatoid; Arthritis, Psoriatic | Details | |
| PM-1016 | PM1016; TILT-123 | Phase 2 Clinical | Tilt Biotherapeutics Ltd | Solid tumours; Ovarian Neoplasms; Squamous Cell Carcinoma of Head and Neck; Peritoneal Neoplasms; Fallopian Tube Neoplasms; Carcinoma, Hepatocellular; Melanoma | Details |
| Etanercept biosimilar (Clover Biopharmaceuticals) | SCB-808 | Phase 3 Clinical | Sichuan Sanyecao Bio-Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Thrombocytopenia | Details |
| Adalimumab biosimilar (Weimingdamu Biotech) | Phase 1 Clinical | Anhui Weiming Damu Biomedicine Co Ltd | Arthritis, Rheumatoid | Details | |
| IBPM005IX (Inbiopro Solutions) | Clinical | Inbiopro Solutions | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Arthritis, Juvenile; Arthritis, Psoriatic; Crohn Disease | Details | |
| NEX-20A | NEX-20A | Phase 1 Clinical | Nanexa AB | Multiple Myeloma | Details |
| Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical) | Phase 3 Clinical | Tonghua Dongbao Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Plaque psoriasis | Details | |
| Adalimumab biosimilar(Incepta) | Phase 3 Clinical | Incepta Pharmaceuticals Ltd | Arthritis, Rheumatoid | Details | |
| EYS-606 | EYS-606 | Phase 2 Clinical | Eyevensys SAS | Uveitis | Details |
| Adalimumab biosimilar (Prestige BioPharma) | PBP-1502 | Phase 1 Clinical | Prestige BioPharma Ltd | Details | |
| Etanercept biosimilar (Suzhou Genemen Biotech) | BF-02; GM-02 | Phase 1 Clinical | Suzhou Genemen Biotech Co Ltd | Spondylitis, Ankylosing | Details |
| Efprezimod alfa | CD24-Fc; HAS-CD24; CD24-Fc-IgG; MK-7110; MK7110 | Phase 3 Clinical | Oncoimmune Inc | Leukemia; Hematopoietic stem cell transplantation (HSCT); HIV Infections; Solid tumours; Graft vs Host Disease; Coronavirus Disease 2019 (COVID-19); Myelodysplastic Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Dyslipidemias; Leukemia, Myeloid, Acute; Melanoma | Details |
| JNJ-61178104 | JNJ-61178104 | Phase 1 Clinical | Janssen Global Services Llc | Autoimmune Diseases | Details |
| HRG-2101 | HRG-2101 | Phase 1 Clinical | Jiangsu Hengrui Medicine Co Ltd | Idiopathic Pulmonary Fibrosis | Details |
| Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical) | Phase 1 Clinical | Qilu Pharmaceutical Co Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing | Details | |
| CC-10015 | CC-10015 | Phase 2 Clinical | Sarcoidosis; Multiple Myeloma; Lupus Erythematosus, Systemic | Details | |
| Etanercept (Neurokine Pharmaceuticals) | NP-1; NK-001 | Clinical | Pivot Pharmaceuticals | Cognition Disorders | Details |
| CC-11050 | CC-11050 | Phase 2 Clinical | HIV Infections; Lupus Erythematosus, Cutaneous; Tuberculosis | Details | |
| Adalimumab biosimilar (Danhong Pharma) | BC-002 | Phase 3 Clinical | Shandong Danhong Pharmaceutical Co Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid | Details |
| Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products) | Phase 3 Clinical | Wuhan Institute Of Biological Products Co Ltd | Plaque psoriasis | Details | |
| Golimumab biosimilar (Bio-thera) | BAT-2506 | Phase 3 Clinical | Bio-Thera Solutions Ltd | Spondylitis, Ankylosing; Arthritis, Rheumatoid; Psoriasis; Arthritis, Psoriatic; Arthritis | Details |
| JNJ-63823539 | JNJ-63823539 | Phase 1 Clinical | Janssen Global Services Llc | Arthritis, Rheumatoid | Details |
| Anti-tumour necrosis factor alpha (Livzon) | Phase 1 Clinical | Livzon Pharmaceutical Group Inc | Autoimmune Diseases | Details | |
| SAR-442970 | SAR-442970 | Phase 1 Clinical | Sanofi | Inflammation | Details |
| Adalimumab biosimilar (Hetero Drugs) | Phase 3 Clinical | Hetero Drugs Ltd | Arthritis, Rheumatoid | Details | |
| Wogonin | Phase 1 Clinical | Shandong Buchang Pharmaceuticals Co Ltd, Hefei Cosource Medicine Technology, Daewoong Pharmaceutical Co Ltd, China Pharmaceutical University | Respiratory Tract Infections; Neoplasms | Details | |
| Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical) | Phase 1 Clinical | North China Pharmaceutical Company Ltd | Arthritis, Rheumatoid; Spondylitis, Ankylosing; Psoriasis | Details | |
| Infliximab biosimilar (Ospedale San Raffaele) | Phase 1 Clinical | Ospedale San Raffaele | Takayasu Arteritis | Details | |
| Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine) | Phase 1 Clinical | Shanghai Harmony Pharmaceutical Technology Co Ltd | Details | ||
| Adalimumab biosimilar (DZM Biotech) | Phase 1 Clinical | Dzm Biotech Ltd | Arthritis, Rheumatoid | Details | |
| Tanfanercept | HBM-9036; HL-036 | Phase 3 Clinical | Hanall | Dry Eye Syndromes; Xerophthalmia | Details |
| Golimumab biosimilar( Alvotech) | Phase 1 Clinical | Alvotech Swiss Ag | Details | ||
| Mufemilast | Hemay-005 | Phase 3 Clinical | Tianjin Hemay Pharmaceutical Co Ltd, Hainan Hailing Chemipharma Corporation Ltd | Spondylitis, Ankylosing; Psoriasis; Arthritis, Psoriatic; Colitis, Ulcerative; Pulmonary Disease, Chronic Obstructive; Behcet Syndrome; Plaque psoriasis; Dermatitis, Atopic | Details |
| ND-009 | ND-009 | Phase 1 Clinical | Numab Therapeutics Ag, Tillotts Pharma Ag | Inflammation | Details |
| Adalimumab biosimilar (Oncobiologics) | ONS-3010 | Phase 3 Clinical | Outlook Therapeutics Inc | Psoriasis | Details |
| Guselkumab/Golimumab | JNJ-78934804 | Phase 2 Clinical | Janssen Research & Development Llc | Colitis, Ulcerative; Crohn Disease | Details |
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