TNF-alpha Protein - ACROBiosystems

TNF-alpha

TNF-alpha Molecule Information

Name:Tumor necrosis factor ?
Target Synonym:Intracellular domain 1;NTF;Cachectin;TNF-a;TNFSF2;ICD2;TNF;Intracellular domain 2;TNF-alpha;N-terminal fragment;Tumor necrosis factor ligand superfamily member 2;TNFA ;Tumor necrosis factor;Tumor necrosis factor, soluble form;Tumor necrosis factor, membra

Number of Launched Drugs:39
Number of Drugs in Clinical Trials:132
Lastest Research Phase:Approved

TNF-alpha Protein Product ListCompare or Buy


TNA-H5228	Human	Human TNF-alpha Protein, His Tag (active trimer) (MALS verified)
TNA-M82E9	Mouse	Biotinylated Mouse TNF-alpha Protein, His,Avitag™ (active trimer) (MALS verified)
TNA-H82E3	Human	Biotinylated Human TNF-alpha Protein, His,Avitag™ (active trimer) (MALS verified)
TNA-H8211	Human	Biotinylated Human TNF-alpha Protein, epitope tag free, ultra sensitivity (primary amine labeling) (active trimer) (MALS verified)
TNA-H4211	Human	ActiveMax® Human TNF-alpha Protein, Tag Free, low endotoxin (active trimer) (MALS verified)

Cat. No.

Species

Product Description

Structure

Purity

Feature

TNA-H5228

Human

Human TNF-alpha Protein, His Tag (active trimer) (MALS verified)

TNA-M82E9

Mouse

Biotinylated Mouse TNF-alpha Protein, His,Avitag™ (active trimer) (MALS verified)

TNA-H82E3

Human

Biotinylated Human TNF-alpha Protein, His,Avitag™ (active trimer) (MALS verified)

TNA-H8211

Human

Biotinylated Human TNF-alpha Protein, epitope tag free, ultra sensitivity (primary amine labeling) (active trimer) (MALS verified)

TNA-H4211

Human

ActiveMax® Human TNF-alpha Protein, Tag Free, low endotoxin (active trimer) (MALS verified)

TNF-alpha Molecule Synonym Name

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNF¦Á

TNF-alpha Molecule Background

Tumor necrosis factor alpha (TNF¦Á) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF¦Á is in the regulation of immune cells. TNF¦Á is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF¦Á production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF¦Á is used as an immunostimulant under the INN tasonermin. TNF¦Á can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha References

TNF-alpha Public Drug Information

Name	Research Code	Research Phase	Company	First Brand Name	First Approved Country	First Indication	First Approved Company	First Approved Date	Indications	Clinical Trials
Etanercept biosimilar (Hanwha Chemical)	HD-203; MK-8953	Approved	Hanwha Chemical						Ankylosing Spondylitis (AS), Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Etanercept-szzs	GP-2015	Approved	Sandoz	ERELZI	fda	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	SANDOZ	2016-08-30	Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Infliximab	TA-650	Approved	Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma	REMICADE	fda	Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	CENTOCOR INC	1998-08-24	Pediatric ulcerative colitis, Psoriasis vulgaris, Crohn's disease, Mucocutaneous lymph node syndrome (Kawasaki syndrome), Psoriatic erythroderma, Ankylosing Spondylitis (AS), Uveitis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Behcet's disease, Pediatric Crohn's disease	Details
Etanercept biosimilar (Nanogen Biopharmaceutical)		Approved	Nanogen Biopharmaceutical Co						Psoriasis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (AXXO)		Approved	AXXO						Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (AryoGen Biopharma)		Approved	AryoGen Biopharma						Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Certolizumab pegol	CZP; CDP-870; PHA-738144,CDP870,PHA738144	Approved	UCB	CIMZIA	fda	Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	UCB INC	2008-04-22	Plaque psoriasis, Spondyloarthritis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (PROBIOMED)		Approved	Probiomed						Rheumatoid arthritis (RA)	Details
Etanercept	TNR-001	Approved	Amgen, Pfizer, Takeda, Boehringer Ingelheim	ENBREL	fda	Pediatric plaque psoriasis, Plaque psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	IMMUNEX	1998-11-02	Juvenile idiopathic arthritis (JIA), Pediatric plaque psoriasis, Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Adalimumab biosimilar (Zydus Cadila)		Approved	Zydus cadila						Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Shanghai CP Guojian Pharmaceutical)		Approved	Shanghai CP Guojian, Cipla		cfda	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA), Plaque psoriasis		2015-01-27	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Samsung Bioepis)	SB-4	Approved	Samsung Bioepis	etanercept	ema		Samsung Bioepis NL B.V.	2016-01-13	Juvenile idiopathic arthritis (JIA), Spondyloarthritis, Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Fujifilm Kyowa Kirin Biologics/Mylan)	FKB-327	Approved	Fujifilm Kyowa Kirin Biologics, Mylan	adalimumab	ema		Mylan S.A.S.	2018-09-16	Plaque psoriasis, Uveitis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Adalimumab biosimilar (Sandoz)	GP-2017	Approved	Sandoz	adalimumab	ema		Sandoz GmbH	2018-07-26	Juvenile idiopathic arthritis (JIA), Uveitis, Spondyloarthritis, Pediatric plaque psoriasis, Ulcerative colitis, Psoriasis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease	Details
Pomalidomide	CC-4047; CDC-394; IMID-4047; IMiD-1	Approved	Celgene	POMALYST	fda	Multiple myeloma (MM)	CELGENE	2013-02-08	Multiple myeloma (MM)	Details
Infliximab biosimilar (Bionovis/The Instituto Vital Brazil)		Approved	Bionovis, The Instituto Vital Brazil						Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (Intas Biopharmaceuticals)		Approved	Intas Biopharmaceuticals						Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Mochida)	LBEC-0101	Approved	Mochida, Ayumi		日本	Rheumatoid arthritis (RA), Juvenile idiopathic arthritis (JIA)	持田制药	2018-01-19 00:00:00.0	Juvenile idiopathic arthritis (JIA), Rheumatoid arthritis (RA)	Details
Adalimumab-adbm	BI-695501	Approved	Boehringer Ingelheim	CYLTEZO	fda	Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	BOEHRINGER INGELHEIM	2017-08-25	Juvenile idiopathic arthritis (JIA), Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	Details
Golimumab	CNTO-148; rTNV148B,CNTO148	Approved	Janssen, Merck Sharp & Dohme, Mitsubishi Tanabe Pharma	SIMPONI	fda	Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	CENTOCOR ORTHO BIOTECH INC	2009-04-24	Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (Amgen)	ABP-710	Approved	Amgen	AVSOLA	fda		AMGEN INC	2019-12-06	Ankylosing Spondylitis (AS), Pediatric ulcerative colitis, Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's disease	Details
Infliximab (ABDA)	SB-2	Approved	Samsung Bioepis, Merck Sharp & Dohme	infliximab	ema		Samsung Bioepis NL B.V.	2016-05-26	Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease	Details
Infliximab-qbtx	PF-06438179; PF-6438179; GP-1111,PF06438179; PF6438179	Approved	Pfizer, Sandoz	IXIFI	fda		PFIZER INC	2017-12-13	Psoriatic erythroderma, Ankylosing Spondylitis (AS), Plaque psoriasis, Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA), Pediatric Crohn's disease	Details
Pentoxifylline	BL-191; EHT-0201; EHT-201	Approved	Us Pharm Holdings	TRENTAL	fda		US PHARM HOLDINGS	1984-08-30	Peripheral vascular disorders	Details
Infliximab (dyyb)	CT-P13,CTP13	Approved	Celltrion, Hospira, Nippon Kayaku	infliximab	ema		Pfizer Europe MA EEIG	2013-09-09	Psoriatic erythroderma, Plaque psoriasis, Ankylosing Spondylitis (AS), Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Rheumatoid arthritis (RA), Crohn's disease, Pediatric Crohn's disease	Details
Adalimumab biosimilar (Fresenius Kabi)	MSB-11022	Approved	Merck Serono, Fresenius Kabi	adalimumab	ema		Fresenius Kabi Deutschland GmbH	2019-04-02	Uveitis, Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (Hisun-Pfizer Pharmaceuticals)		Approved	Hisun-Pfizer						Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
PG-201	PG-201,PG 201	Approved	ViroMed, PMG Pharm						Osteoarthritis (OA)	Details
Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)	GS-071; NI-071	Approved	Nichi-Iko Pharmaceutical, Aprogen, Zeria, Ayumi	Infliximab biosimilar (Nichiiko Pharmaceutical/Aprogen)	日本	Rheumatoid arthritis (RA), Psoriasis vulgaris, Psoriatic arthritis, Pustular psoriasis, Crohn's disease, Ulcerative colitis	Nichi-Iko Pharmaceutical,Zeria	2017-09-27 00:00:00.0	Pustular psoriasis, Ulcerative colitis, Psoriatic arthritis, Psoriasis vulgaris, Crohn's disease, Rheumatoid arthritis (RA)	Details
Luminol sodium	MP-1032,MP1032	Approved	Metrio, Selvim						Psoriasis, Immunological disorders	Details
Adalimumab-afzb	PF-06410293	Approved	Pfizer	ABRILADA	fda		PFIZER INC	2019-11-15	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Amgen)	ABP-501	Approved	Amgen, Daiichi Sankyo	AMJEVITA	fda	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	AMGEN INC	2016-09-23	Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Plaque psoriasis, Ulcerative colitis, Hidradenitis suppurativa, Psoriatic arthritis, Crohn's disease, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Samsung Bioepis)	SB-5	Approved	Samsung Bioepis	adalimumab	ema		Samsung Bioepis NL B.V.	2017-08-24	Pediatric plaque psoriasis, Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Uveitis, Ankylosing Spondylitis (AS), Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Pediatric Crohn's disease	Details
Lenalidomide	CDC-501; CC-5013; CDC-5013; ENMD-0997; IMID-5013; IMiD-3	Approved	Celgene, BeiGene	REVLIMID	fda	Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM)	CELGENE	2005-12-27	Myelodysplastic syndrome (MDS), Mantle cell lymphoma (MCL), Multiple myeloma (MM), Peripheral T cell lymphoma (PTCL)	Details
Adalimumab	D2E7; LU-200134; ABT-D2E7	Approved	Abbvie	HUMIRA	fda		ABBVIE INC	2002-12-31	Spondyloarthritis, Hidradenitis suppurativa, Crohn's disease, Juvenile idiopathic arthritis (JIA), Ankylosing Spondylitis (AS), Plaque psoriasis, Uveitis, Pustular psoriasis, Psoriasis, Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA), Pediatric Crohn's disease	Details
Infliximab biosimilar (Reliance Life Sciences)	BOW-015; R-TPR-015	Approved	EPIRUS Biopharmaceuticals, Sun Pharmaceutical						Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Bio-Thera Solutions)	BAT-1406	Approved	Bio-Thera Solutions	Adalimumab Injection	cfda	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA), Psoriasis		2019-11-04	Ankylosing Spondylitis (AS), Psoriasis, Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (AXXO)		Approved	AXXO						Autoimmune diseases, Crohn's disease	Details
Adalimumab biosimilar (Hisun Pharma)	HS-016,HS016	Approved	Hisun Pharm	Adalimumab Solution for Injection	cfda	Ankylosing Spondylitis (AS)		2019-12-06	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Amega Biotech)		Approved	Amega Biotech						Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Mycenax Biotech/TSH Biopharm)	E-11; ENIA-11,E11; ENIA11	Approved	Mycenax Biotech, TSH Biopharm						Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Reliance Life Sciences)	R-TPR-021	Approved	Reliance Life Sciences, Torrent Pharmaceuticals						Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Thalidomide	NSC-527179; NSC-66847; K-17,NSC527179; NSC66847; K17,NSC 527179; NSC 66847; K 17	Approved	Celgene	THALOMID	fda	Erythema nodosum leprosum (ENL), Multiple myeloma (MM)	CELGENE	1998-07-16	Erythema nodosum leprosum (ENL), Multiple myeloma (MM)	Details
Anti-tumour necrosis factor-alpha antibody		Approved	Materia Medica Holding Research and Production Company						Osteoarthritis (OA), Rheumatoid arthritis (RA)	Details

TNF-alpha Clinical Drug Information

Name	Research Code	Research Phase	Company	Indications	Clinical Trials
tgAAC 94		Phase Ⅱ	Armata Pharmaceuticals	Rheumatoid arthritis (RA), Periodontal disease	Details
Infliximab biobetter (Mabtech/Sorrento)	STI-002	Phase Ⅲ	Taizhou Mabtech, Sorrento Therapeutics	Rheumatoid arthritis (RA)	Details
CMAB815	CMAB815,CMAB-815; CMAB 815	IND Filing	Shanghai Biomabs, SinoMab Bioscience Ltd	Rheumatoid arthritis (RA)	Details
Human TNF-α monoclonal antibody( Simcere Pharmaceutical)		IND Filing	Nanjing XianSheng Dongyuan Pharmaceutical, Shandong Xiansheng Medejin Bio-pharmaceutical, Simcere	Unspecified	Details
Recombinant anti-TNFα monoclonal antibody (Wuhan Institute of Biological Products)		Phase Ⅰ	Wuhan Institute of Biological Products	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα antibody (Shanghai Xiesheng Medicine)		Phase Ⅰ	Shanghai Xiesheng Pharmaceutical Technology	Unspecified	Details
Adalimumab biosimilar (Shanghai Maitaiyabo Biotech)		IND Filing	Shanghai Maitai Yabo Biological Technology	Rheumatoid arthritis (RA)	Details
Hemay007	Hemay-007	Phase Ⅱ	Tianjin Hemay Biotech	Ulcerative colitis	Details
BLX-1002	BLX-1002	Phase Ⅱ	Orchid	Type 2 diabetes	Details
Azacitidine/Lenalidomide		Phase Ⅱ	Celgene	Acute myeloid Leukemia (AML)	Details
Adalimumab biosimilar (Bionovis/The Instituto Vital Brazil)		Phase Not Specified	Bionovis, The Instituto Vital Brazil	Plaque psoriasis, Ankylosing Spondylitis (AS), Ulcerative colitis, Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease	Details
EYS-606	EYS-606	Phase Ⅱ	Eyevensys	Uveitis	Details
Infliximab biosimilar (Shanghai CP Guojian)		Phase Ⅲ	Shanghai CP Guojian	Rheumatoid arthritis (RA)	Details
HMPL-004 (Hutchison Medipharma)	HMPL-004	Phase Ⅲ	Hutchison Medipharma	Ulcerative colitis, Crohn's disease	Details
Recombinant anti-TNFα antibody (Sailemin Biotech)		IND Filing	Hainan Sailemin Biological Technology	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
REN-1654	CPI-1189; REN-1189; REN-1654,REN1654,REN1189,CPI1189	Phase Ⅱ	Evotec	Postherpetic neuralgia (PHN), Sciatica	Details
Adalimumab biosimilar (LG Life Sciences)	LBAL	Phase Ⅲ	LG Chem, Mochida	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Beijing Luzhu Biotechnology)		Phase Ⅰ	Beijing Luzhu Biotechnology	Rheumatoid arthritis (RA)	Details
ONO-4007	ONO-4007	Phase Ⅱ	Ono Pharmaceutical	Cancer chemotherapy	Details
Recombinant human anti-TNFα monoclonal antibody (Taizhou Mabtech)		IND Filing	Taizhou Mabtech	Unspecified	Details
PUR-0110	PUR-0110; PCT-233	Phase Ⅱ	PurGenesis Technologies	Ulcerative colitis	Details
ISIS-104838	ISIS 104838	Phase Ⅱ	Ionis	Psoriasis, Rheumatoid arthritis (RA)	Details
CC-10015	CC-10015	Phase Ⅱ	Celgene	Sarcoidosis	Details
LP-0058	LP-0058; LEO-32731,LP0058,LEO32731	Phase Ⅱ	Leo Pharma	Psoriasis, Atopic dermatitis	Details
GSK-2800528	GSK-2800528,GSK 2800528,GSK2800528	Phase Ⅰ	GlaxoSmithKline	Psoriasis, Inflammation	Details
Adalimumab biosimilar (Oncobiologics)	ONS-3010	Phase Ⅲ	Outlook Therapeutics	Plaque psoriasis	Details
LY-3114062	LY-3114062,LY3114062	Phase Ⅰ	Lilly	Arthritis	Details
Adalimumab biosimilar (CTTQ Pharma)		Phase Ⅰ	Chiatai Tianqing (CTTQ)	Rheumatoid arthritis (RA)	Details
QR-449	QR-440; QR-443; QR-449	Phase Ⅰ	ProPhase Labs	Cachexia, Metabolic disorders, Pain	Details
Infliximab biosimilar (Shanghai Biomabs)	CMAB-008	BLA Filing	Shanghai Biomabs	Rheumatoid arthritis (RA)	Details
HP-228	HP-228; ILP-228	Phase Ⅱ	Sygnis	Obesity, Type 2 diabetes, Postoperative pain, Inflammation	Details
Adalimumab biosimilar (Coherus BioSciences)	CHS-1420	Phase Ⅲ	Coherus Biosciences	Plaque psoriasis	Details
Adalimumab biosimilar (CinnaGen)		Phase Ⅲ	CinnaGen	Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (Biocad)	BCD-055	Phase Ⅲ	Biocad	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Infliximab biosimilar (Genor Biopharma)	GB-242,GB242	Phase Ⅲ	Genor Biopharma	Rheumatoid arthritis (RA)	Details
CDP-571	CDP-571; BAY-10-3356; cb-0010,CDP 571; BAY 10 3356; cb 0010,CDP571; BAY103356; cb0010	Phase Ⅲ	Celltech, Biogen	Type 2 diabetes, Septic shock, Rheumatoid arthritis (RA), Crohn's disease	Details
Adalimumab biosimilar (Biocad)	BCD-057	BLA Filing	Biocad	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα monoclonal antibody (Livzon Group)	AT-132; LZM-001	Phase Ⅱ	Livzon Group Livzon Pharmaceutical Factory	Rheumatoid arthritis (RA)	Details
Placulumab	ART-621; CEP-37247; PN-0621; Dom-0200	Phase Ⅱ	Peptech UK, Domantis, Arana, Teva	Psoriasis, Inflammation, Rheumatoid arthritis (RA), Sciatica	Details
Recombinant human TNF-α monoclonal antibody (Sinocelltech)	SCT-630	Phase Ⅲ	Sinocelltech	Plaque psoriasis	Details
AZD-9773 (BTG)		Phase Ⅱ	BTG plc, AstraZeneca	Septic shock, Sepsis	Details
JNJ-63823539	JNJ-63823539	Phase Ⅰ	Janssen	Rheumatoid arthritis (RA)	Details
MM-A01-01	MM-A01-01,MMA0101	Phase Ⅱ	Myungmoon Pharm	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Bionovis/The Instituto Vital Brazil)		Phase Not Specified	Bionovis, The Instituto Vital Brazil	Plaque psoriasis, Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Hemay-005	Hemay-005	Phase Ⅱ	Tianjin Hemay Biotech, Hainan Hailing Chemipharma Corporation Limited	Plaque psoriasis	Details
Adalimumab biosimilar (Alphamab)	KN-002	Phase Ⅰ	Alphamab	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Genor Biopharma)	BCD-100; GB-232	Phase Ⅰ	Genor Biopharma, Biocad	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Danhong Pharma)	BC-002	Phase Ⅰ	Danhong Pharma	Plaque psoriasis, Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
NPH-30907	NPH-30907	Phase Ⅱ	Piramal Phytocare	Fungal infection	Details
Adalimumab biosimilar (Tonghua Dongbao Pharmaceutical)		Phase Ⅲ	Tonghua Dongbao Pharmaceutical	Plaque psoriasis	Details
Adalimumab biosimilar (Shanghai Henlius Biotech)	HLX-03	BLA Filing	Shanghai Henlius Biotech	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Mylan/Biocon)	BMO-2; MYL-1401-A	BLA Filing	Biocon, Mylan	Psoriasis, Rheumatoid arthritis (RA)	Details
INDUS-83030	INDUS-83030	Phase Not Specified	Indus Biotech Private Limited	Rheumatoid arthritis (RA)	Details
AMG-548	AMG-548	Phase Ⅰ	Amgen	Rheumatoid arthritis (RA), Arthritis	Details
Recombinant human anti-TNFα monoclonal antibody (Qilu Pharmaceutical)		Phase Ⅰ	Qilu Pharmaceutical	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Zenotech Laboratories)		Phase Not Specified	Zenotech laboratories	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (HEC Pharma)		IND Filing	HEC Pharm	Rheumatoid arthritis (RA)	Details
Recombinant chimeric anti-TNFα antibody (Hisun Pharma)	HS-626	Phase Ⅲ	Hisun Pharm	Plaque psoriasis	Details
ABT-122	ABT-122; D2E7-GS10-B6-17	Phase Ⅱ	Abbvie	Rheumatic disorders, Psoriatic arthritis	Details
Tumour necrosis factor alpha kinoid	TNF-K; TNF-K005	Phase Ⅱ	Neovacs	Rheumatoid arthritis (RA), Crohn's disease	Details
Etanercept biosimilar (Clover Biopharmaceuticals)	SCB-808	Phase Ⅲ	Clover Biopharmaceuticals	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Qilu Pharmaceutical)	QL-0902	BLA Filing	Qilu Pharmaceutical	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
IBPM005IX (Inbiopro Solutions)		Phase Not Specified	Inbiopro Solutions	Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA), Crohn's disease, Juvenile rheumatoid arthritis (JRA)	Details
Etanercept biosimilar (AvesthaGen)		Phase Ⅲ	Avesthagen	Rheumatoid arthritis (RA)	Details
K-832	K-832	Phase Ⅱ	Kowa	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Momenta Pharmaceuticals)	BAX-2923; M-923; BAX-923	Phase Ⅲ	Momenta, Shire	Plaque psoriasis, Autoimmune diseases, Inflammation, Rheumatoid arthritis (RA)	Details
AN-0128	AN-0128; CRM-0005; ONT-0001,AN0128,ONT0001,CRM0005	Phase Ⅱ	Anacor Pharmaceuticals	Atopic dermatitis	Details
V-565	V-565	Phase Ⅱ	VHSquared	Crohn's disease	Details
Etanercept biosimilar (Shanghai Fudan-Zhangjiang Bio-Pharmaceutical)		BLA Filing	Shanghai Fudan-Zhangjiang Bio-Pharmaceutical	Rheumatoid arthritis (RA)	Details
Anti-tumour necrosis factor alpha (Livzon)		Phase Ⅰ	Livzon Group	Autoimmune diseases	Details
Adalimumab with ENHANZE technology (Abbvie)		Phase Ⅰ	Abbvie	Unspecified	Details
Recombinant human anti-TNFα monoclonal antibody (Weimingdamu Biotech)		Phase Ⅰ	Anhui Sinobioway Damu Biomedicine	Rheumatoid arthritis (RA)	Details
AME-527	AME-527	Phase Ⅱ	Applied Molecular Evolution	Rheumatoid arthritis (RA)	Details
YS-IL6	YS-IL6; YSIL-6; YSIL6-O-RA; YSIL6-T-PS	Phase Ⅱ	Y's Therapeutics	Rheumatoid arthritis (RA)	Details
OCT-B201	OCT-B201; BT-201	Phase Ⅰ	Oscotec	Osteoarthritis (OA)	Details
Certolizumab (Intrexon)	AG-014	Phase Ⅰ	Intrexon Corporation	Inflammatory bowel disease	Details
DLX-105	DLX-105; ESBA-105	Phase Ⅱ	ESBATech, Cell Medica	Uveitis, Plaque psoriasis, Crohn's disease, Dry eye disease	Details
Etanercept biosimilar (Biotrion)	BT-D001	Phase Ⅲ	Biotrion	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Shanghai Celgen)		Phase Ⅲ	Shanghai Celgen Bio	Plaque psoriasis	Details
Adalimumab biosimilar (Innovent Biologics)	IBI-303	BLA Filing	Innovent Biologics	Ankylosing Spondylitis (AS)	Details
AVX-470	AVX-1350; AVX-470; AVX-470h	Phase Ⅰ	Avaxia Biologics	Ulcerative colitis	Details
COVA-322	COVA-322	Phase Ⅱ	Covagen	Plaque psoriasis	Details
CYT 007 TNFQb		Phase Ⅱ	Cytos	Psoriasis, Rheumatoid arthritis (RA)	Details
MNX-160	LMP-160; MNX-160	Preclinical	Nonindustrial source, Macronex	Cachexia, Diabetes, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA), Asthma, Adult respiratory distress syndrome (ADRS)	Details
KOB-03	KOB-03	Phase Ⅱ	Dong Wha Pharmaceuticals	Allergic rhinitis (AR)	Details
Adalimumab biosimilar (Alvotech)	AVT-02 (Alvotech)	Phase Ⅲ	Alvotech	Plaque psoriasis, Autoimmune diseases	Details
BIRB-1017	BIRB-1017	Phase Not Specified	Boehringer Ingelheim	Psoriasis, Rheumatoid arthritis (RA)	Details
Etanercept (Neurokine Pharmaceuticals)	NK-001; NP-1	Phase Not Specified	Pivot Pharmaceuticals	Cognitive disorders	Details
ENMD-0995	S-3APG; ENMD-0995	Phase Ⅰ	Celgene, Boston Children's Hospital	Multiple myeloma (MM)	Details
PMI-001	PMI-001,PMI 001,PMI001	Phase Ⅲ	Phytomedics	Lupus vulgaris, Psoriasis, Multiple sclerosis (MS), Rheumatoid arthritis (RA)	Details
Recombinant anti-TNFα human monoclonal antibody (Jilin Kanghui Biotech)		IND Filing	Jilin Kanghui Biological Technology	Unspecified	Details
Adalimumab biosimilar (Hualan Biological Engineering)		Phase Ⅰ	Hualan Biological Engineering	Ankylosing Spondylitis (AS), Psoriasis, Rheumatoid arthritis (RA)	Details
Golimumab biosimilar (Bio-thera)	BAT-2506	Phase Ⅰ	Bio-Thera Solutions	Ankylosing Spondylitis (AS), Psoriatic arthritis, Rheumatoid arthritis (RA)	Details
Ozoralizumab	ATN-103; PF-05230896; PF-5230896; TS-152	Phase Ⅲ	Ablynx, Eddingpharm, Pfizer, Taisho Pharmaceutical	Rheumatoid arthritis (RA)	Details
DOM-0215	DOM-0215,Dom 0215,Dom0215	Preclinical	GlaxoSmithKline	Rheumatoid arthritis (RA)	Details
Human anti-TNFα monoclonal antibody (DZM Biotech)		Phase Ⅰ	DZM Biotech	Rheumatoid arthritis (RA)	Details
YHB-1411-2	YHB-1411-2; YHB1411-2; YHB-14112; MAb YHB1411-2	Phase Ⅰ	Yuhan Corporation	Rheumatoid arthritis (RA)	Details
LY-3114062	LY-3114062; LY3114062	Phase Ⅰ	Lilly	Arthritis	Details
Recombinant human monoclonal antibody specific for human tumor necrosis factor (North China Pharmaceutical)		Phase Ⅰ	North China Pharmaceutical	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
ABBV-257	ABBV-257; DVD-1; DVD-Ig-1	Phase Ⅰ	Abbott	Rheumatoid arthritis (RA)	Details
NV-52	NV-52; NV-07β	Phase Ⅱ	Novogen	Ulcerative colitis, Crohn's disease, Inflammatory bowel disease	Details
Lenercept	TNFR55-Ig1; RO-452081; p55TNFR-Ig; NFR55-IgG1	Phase Ⅲ	Roche	Septic shock, Rheumatoid arthritis (RA)	Details
PF-5230905	ATN-192; PF-05230905; PF-5230905	Phase Ⅰ	Ablynx	Rheumatoid arthritis (RA)	Details
Tanfanercept	HBM-9036; HL-036	Phase Ⅲ	HanAll, Harbour BioMed, Daewoong	Dry eye disease	Details
Adalimumab biosimilar (Jiangsu Zhonghe)	UBP-1211,UBP1211; UBP 1211	Phase Ⅲ	Jiangsu Zhonghe Medicine, Shanghai Junshi Biosciences	Rheumatoid arthritis (RA)	Details
Adalimumab biosimilar (Celltrion)	CT-P17	Phase Ⅲ	Celltrion	Rheumatoid arthritis (RA)	Details
Anti-TNFalpha polyclonal antibody (Verigen)		Phase Ⅱ	Genzyme, Italchimici	Crohn's disease, Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (Coherus Biosciences)	BAX-2200; CHS-0214	Phase Ⅲ	Coherus Biosciences, Daiichi Sankyo	Plaque psoriasis, Rheumatoid arthritis (RA)	Details
SA-13353	DE-096; SA-13353,DE096,SA13353	Phase Ⅱ	Santen, Ayumi	Rheumatoid arthritis (RA), Diabetic macular edema	Details
Adalimumab biosimilar (Dong-A ST/Meiji Seika Pharma)	DA-3113; DMB-3113	Phase Ⅰ	Dong-A Pharmaceutical, Meiji Seika Pharma	Rheumatoid arthritis (RA)	Details
Ro-327315	Ro-327315; Ro-32-7315	Phase Ⅰ	Roche	Rheumatoid arthritis (RA)	Details
Etanercept biosimilar (YL Biologics)	YLB-113	BLA Filing	Lupin, YL Biologics	Rheumatoid arthritis (RA), Juvenile rheumatoid arthritis (JRA)	Details
Recombinant mutant human tumor necrosis factor alpha (State Key Laboratory of Cancer Biology)		Phase Ⅱ	State Key Laboratory of Cancer Biology	Gastric cancer, Colorectal cancer, Lung cancer, Renal carcinoma, Head and neck cancer	Details
Recombinant humanized anti-TNFα monoclonal antibody (Shenzhen Main Luck Pharmaceuticals)		IND Filing	Shenzhen Main Luck Pharmaceuticals	Ankylosing Spondylitis (AS), Rheumatoid arthritis (RA)	Details
ABX-0401	ABX-0401	Phase Ⅱ	Sanofi, Pfizer	Immune-inflammatory diseases, Rheumatoid arthritis (RA), Inflammatory bowel disease	Details
Adalimumab biosimilar (Prestige BioPharma)	PBP-1502	Phase Ⅰ	Prestige BioPharma, Huons	Arthritis	Details
Adalimumab biosimilar (Hetero Drugs)		Phase Ⅲ	Hetero Drugs	Rheumatoid arthritis (RA)	Details
BB-2275	BB-2275	Preclinical	Vernalis	Cachexia, AIDS related cachexia, Cancer related cachexia	Details
Recombinant human TNF-α monoclonal antibody(SL Pharma/Combio)	KM113	IND Filing	Beijing ShuangLu Pharmaceutical, Combio	Autoimmune diseases	Details
Genz-29155	Genz-29155	Phase Ⅰ	Sanofi	Transplant rejection, Multiple sclerosis (MS)	Details
Doramapimod	BIBR-796; BIRB-0796; BIRB-796; BIRB-796-BS,BIBR796,BIRB0796,BIRB796 BS	Phase Ⅲ	Boehringer Ingelheim	Psoriasis	Details
Adalimumab biosimilar (Synermore Biologics)	SYN-060	IND Filing	Synermore Biologics, Lonn Ryonn Pharma	Rheumatoid arthritis (RA)	Details
OCS-02	OCS-02	Phase Ⅱ	Oculis Pharma, Novartis	Dry eye disease	Details
Adalimumab biosimilar (Eastern Biotech)	JY-026,JY026	Phase Ⅰ	Eastern Biotech	Juvenile idiopathic arthritis (JIA), Plaque psoriasis, Ankylosing Spondylitis (AS), Crohn's disease, Rheumatoid arthritis (RA)	Details
BCD-121	BCD-121	Phase Ⅰ	Biocad	Rheumatoid arthritis (RA)	Details
Golnerminogene pradenovec	ADgvEGR.TNF.11D	Phase Ⅲ	Asahi Kasei, GenVec, National Cancer Institute	Pancreatic cancer	Details
Acetylcysteine/Pentoxifylline	PTL-202	Phase Ⅰ	Pacific Therapeutics, IntelGenx Corp, RA Chem Pharma	Idiopathic pulmonary fibrosis (IPF)	Details
Wogonin		Phase Ⅰ	Daewoong, China Pharmaceutical University, Hefei Cosource Medicine Technology, Buchang Pharma	Gastric cancer, Leukemia, Liver cancer	Details