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TNF-alpha

TNF-alpha Overview

English NameTumor necrosis factor αApproved Drugs64
Drugs in Clinical Trials58Target SynonymICD1，Tumor necrosis factor，Tumor Necrosis Factor (TNF Superfamily， Member 2)，Tumor Necrosis Factor Ligand 1F，Tumor Necrosis Factor-Alpha，TNF Superfamily， Member 2，TNF， Macrophage-Derived，TNF， Monocyte-Derived，APC1 Protein，TNLG1F，DIF，NTF，TNF-a，TNF-alpha，ICD2，N-terminal fragment，TNF，Tumor necrosis factor ligand superfamily member 2，Cachectin，TNFSF2，TNFA
Highest Development StageApproved
English NameTumor necrosis factor α
Target SynonymICD1，Tumor necrosis factor，Tumor Necrosis Factor (TNF Superfamily， Member 2)，Tumor Necrosis Factor Ligand 1F，Tumor Necrosis Factor-Alpha，TNF Superfamily， Member 2，TNF， Macrophage-Derived，TNF， Monocyte-Derived，APC1 Protein，TNLG1F，DIF，NTF，TNF-a，TNF-alpha，ICD2，N-terminal fragment，TNF，Tumor necrosis factor ligand superfamily member 2，Cachectin，TNFSF2，TNFA
Approved Drugs64
Drugs in Clinical Trials58
Highest Development StageApproved

TNF-alpha Product List

  • Product Category

    Protein (13)Kits (12)Antibody (5)Cell (1)

  • Product Status

    Launched (31)

  • Species

    Human (19)Mouse (10)Canine (1)Cynomolgus (1)

  • Tag

    Tag Free (4)His Tag & Avi Tag (2)His Tag (4)- (13)Mouse IgG1 (2)Human IgG1 (3)Fc Tag (2)Fc Tag & Avi Tag (1)

  • Conjugate

    Unconjugated (13)Biotin-labeled (5)- (12)HRP Labeled (1)

Total: 31
  • 1
  • 2
  • 3
  • 4

TNF-alpha Background

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

TNF-alpha Synonyms

DIF,TNF-alpha,TNFA,TNFSF2,cachexin,cachectin,TNFα

Product Reviews

  • P***s2024-11-15
    3People Like
    Human TNF-alpha Protein, His Tag, active trimer (MALS verified)
    We used this product to conduct binding affinity measurements with molecular modulators that were designed to bind to TNFα In Vitro. Experiment applied was Microscale Thermophoresis that detects binding and, with dilution series, binding affinity between TNFα and test molecule. Results showed low micro molar binding, which showed that TNFα and test molecule behaved as we hoped for! Now we ordered more of this protein for further tests
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