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Your Position: Home > All Other Proteins > TGF-beta RII > TG2-H5252

Human TGF-beta RII / TGFBR2 Protein, Fc Tag (MALS verified)

  • Synonym
    TGFBR2,TGFR2,TbetaR-II,TGFβR2
  • Source
    Human TGFBR2, Fc Tag (TG2-H5252) is expressed from human 293 cells (HEK293). It contains AA Thr 23 - Asp 159 (Accession # NP_003233).
    Predicted N-terminus: Thr 23
  • Molecular Characterization
    Online(Thr 23 - Asp 159) NP_003233

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 42.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) SDS-PAGE gel

Human TGFBR2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human TGFBR2, Fc Tag (Cat. No. ) MALS images

The purity of Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) was more than 90% and the molecular weight of this protein is around 105-120 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human TGFBR2, Fc TagHuman TGFBR2, Fc Tag (Cat. No. TG2-H5252) ELISA bioactivity

Immobilized Human TGFB1, His Tag (Cat. No. TG1-H524x) at 1 μg/mL (100 μL/well) can bind Human TGFBR2, Fc Tag (Cat. No. TG2-H5252) with a linear range of 0.3-2 ng/mL (QC tested).

  • Citations
  • Background
    TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $315.00

Price(USD) : $1980.00

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Drug Development Status

  • Number of Launched Drugs:2 Details
  • Number of Drugs in Clinical Trials:3 Details
  • Latest Research Phase:Approved

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