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Your Position: Home > All Other Proteins > CD79B > Human CD79b /B29 Protein,C-Fc Tag

Human CD79B Protein, Fc Tag

  • Synonym
    CD79b,B29,IGB,Ig-beta
  • Source
    Human CD79B, Fc Tag (CDB-H5259) is expressed from human 293 cells (HEK293). It contains AA Ala 29 - Asp 159 (Accession # NP_000617).
    Predicted N-terminus: Ala 29
  • Molecular Characterization
    CD79B(Ala 29 - Asp 159) NP_000617

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 41.8 kDa. The protein migrates as 50-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >92% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human CD79B, Fc Tag (Cat. No. CDB-H5259) SDS-PAGE gel

Human CD79B, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

  • Background
    B-cell antigen receptor complex-associated protein beta chain (CD79b) is also known as B-cell-specific glycoprotein B29, Ig-beta,Immunoglobulin-associated B29 protein, B29 and IGB, which is a single-pass type I membrane protein containing one Ig-like V-type ( immunoglobulin-like ) domain and one ITAM domain.CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR).CD79b can enhance phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. Defects in CD79b are the cause of agammaglobulinemia type 6 (AGM6) that is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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CD79B Products

  • Name:B-cell antigen receptor complex-associated protein beta chain
  • Classification:Homo sapiens
  • Number of Launched Drugs:0 Details
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