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Your Position: Home > Other Recombinant Proteins > CRTAM > Cynomolgus CRTAM Protein, Fc Tag

Cynomolgus CRTAM Protein, Fc Tag

  • Synonym
    CRTAM
  • Source
    Cynomolgus CRTAM, Fc Tag (CRM-C5255) is expressed from human 293 cells (HEK293). It contains AA Ser 18 - Gly 287 (Accession # XP_005580021.1).
    Predicted N-terminus: Ser 18
  • Molecular Characterization
    CRTAM(Ser 18 - Gly 287) XP_005580021.1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 56.6 kDa. The protein migrates as 85-95 kDa under reducing (R) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss is observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus CRTAM, Fc Tag (Cat. No. CRM-C5255) SDS-PAGE gel

Cynomolgus CRTAM, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

  • Background
    Class I-restricted T cell-associated molecule (CRTAM), a member of nectin family and the immunoglobulin superfamily, is also known as cytotoxic and regulatory T-cell molecule, which is expressed by activated CD8+ and NK T cells. CRTAM is found in spleen, thymus, small intestine, peripheral blood, and surprisingly, in brain where it is highly expressed by Purkinje cells of the cerebellum. The high affinity of CRTAM/IGSF4 adhesion allows CRTAM to disrupt IGSF4 homotypic interactions (3 - 5). IGSF4 and T cell receptor co-engagement of CRTAM-expressing CD8+ cells induces increased IFN-gamma or IL-22 production (3, 4). Furthermore, a role in cancer surveillance through NK cell-mediated rejection of IGSF4-expressing tumors has been proposed.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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