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Your Position: Home > Protein > FKBP4 > FK4-H52Q3

Human FKBP4 / FKBP52 Protein, His,PA Tag

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  • Synonym
    FKBP4,FKBP52
  • Source
    Human FKBP4, His,PA Tag(FK4-H52Q3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Ala 459 (Accession # AAH01786 ).
    Predicted N-terminus: Met 1
  • Molecular Characterization
    FKBP4 Structure

    This protein carries a polyhistidine tag at the C-terminus, followed by a PA tag, and has a calculated MW of 55.1 kDa. The reducing (R) protein migrates as 60 kDa in SDS-PAGE.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
FKBP4 SDS-PAGE

Human FKBP4, His,PA Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) is also known as immunophilin FKBP52. FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP4 has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.
  • Clinical and Translational Updates

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