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Your Position: Home > All Other Proteins > Glypican 3 > Mouse Glypican 3 / GPC3 Protein, Fc Tag

Mouse Glypican 3 / GPC3 Protein, Fc Tag

  • Synonym
  • Source
    Mouse Glypican 3, Fc Tag (GP3-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Met 557 (Accession # NP_057906).
    Predicted N-terminus: Gln 25, Ser358
  • Molecular Characterization
    Online(Gln 25 - Met 557) NP_057906

    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 87.2 kDa. GP3-M5254 may be cleaved into secrete GPC3, short propeptide (aa ?-557) & Fc tag, long propeptide (aa 358-557 predicted) & Fc tag. The protein migrates as 100 kDa (secrete GPC3 & propeptide & Fc tag), 58 kDa (long propeptide & Fc tag), 40 kDa (short propeptide & Fc tag) on a SDS-PAGE gel under reducing (R) condition.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% GPC3 and 2-8% human IgG1 Fc fragment as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    No activity loss was observed after storage at:

    1. 4-8°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Mouse Glypican 3, Fc Tag (Cat. No. GP3-M5254) SDS-PAGE gel

Mouse Glypican 3, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Mouse Glypican 3, Fc TagMouse Glypican 3, Fc Tag (Cat. No. GP3-M5254) ELISA bioactivity

Immobilized Human FGF basic, Tag Free (Cat. No. BFF-H4117) at 2μg/mL (100 μL/well) can bind Mouse Glypican 3, Fc Tag (Cat. No. GP3-M5254) with a linear range of 1.22-9.7 ng/mL (QC tested).

  • Background
    Glypican-3 (GPC3) is also known as Intestinal protein OCI-5, GTR2-2, MXR7, which belongs to the glypican family. Glypican 3 / GPC-3 is highly expressed in lung, liver and kidney. Glypican-3 inhibits the dipeptidyl peptidase activity of DPP4. Glypican-3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and also may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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