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Your Position: Home > Protein > OX40 Ligand > TN4-M5241

Mouse OX40 Ligand / TNFSF4 Protein, His Tag

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  • Synonym
    OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L
  • Source
    Mouse OX40 Ligand, His Tag(TN4-M5241) is expressed from human 293 cells (HEK293). It contains AA Gln 49 - Leu 198 (Accession # P43488-1 ).
    Predicted N-terminus: His
  • Molecular Characterization
    OX40 Ligand Structure

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 18.3 kDa. The protein migrates as 20 kDa and 22-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
OX40 Ligand SDS-PAGE

Mouse OX40 Ligand, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

Bioactivity-ELISA
 OX40 Ligand ELISA

Immobilized Mouse OX40 Ligand, His Tag (Cat. No. TN4-M5241) at 0.5 μg/mL (100 μL/well) can bind Mouse OX40, Fc Tag (Cat. No. OX0-M5259) with a linear range of 0.2-16 ng/mL (QC tested).

  • Background
    Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $370.00

Price(USD) : $2680.00

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  • Number of Drugs in Clinical Trials:6 Details
  • Latest Research Phase:Phase 3 Clinical

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