This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 42.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
>95% as determined by SDS-PAGE.
>90% as determined by SEC-HPLC.
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
Human PD-1, Mouse IgG2a Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
The purity of Human PD-1, Mouse IgG2a Fc Tag (Cat. No. PD1-H5255) was greater than 90% as determined by SEC-HPLC.
Immobilized Human PD-1, Mouse IgG2a Fc Tag (Cat. No. PD1-H5255) at 2 μg/mL (100 μL/well) can bind Nivolumab with a linear range of 0.1-2 ng/mL (Routinely tested).
Immobilized Human PD-L1, His Tag (Cat. No. PD1-H5229) at series of concentration on MonRabTM Anti-His Tag (C-term) Antibody precoated (0.1 μg/well) plate, can bind Human PD-1, Mouse IgG2a Fc Tag (Cat. No. PD1-H5255) at 5 μg/mL (100 μL/well) with a linear range of 10-78 ng/mL (Routinely tested).
Loaded Human PD-1, Mouse IgG2a Fc Tag (Cat. No. PD1-H5255) on Protein A Biosensor, can bind Human PD-L1, His Tag (Cat. No. PD1-H5229) with an affinity constant of 2.6 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Loaded Human PD-1, Mouse IgG2a Fc Tag (Cat. No. PD1-H5255) on Protein A Biosensor, can bind Human PD-L2, His Tag (Cat. No. PD2-H5220) with an affinity constant of 0.43 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.
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