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Your Position: Home > Protein > ICOS > ICS-M52H8

Mouse ICOS / CD278 (C137S, C138S) Protein, His Tag

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  • Synonym
    ICOS,CD278,AILIM,Inducible T-cell costimulator
  • Source
    Mouse ICOS (C137S, C138S) Protein, His Tag (ICS-M52H8) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Leu 144 (Accession # Q9WVS0-1(C137S, C138S)).
    Predicted N-terminus: Glu 21
  • Molecular Characterization
    Online(Glu 21 - Leu 144) Q9WVS0-1 (C137S,C138S)

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 15.7 kDa. The protein migrates as 22-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Mouse ICOS (C137S, C138S) Protein, His Tag (Cat. No. ICS-M52H8) SDS-PAGE gel

Mouse ICOS (C137S, C138S) Protein, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Mouse ICOS (C137S, C138S) Protein, His TagMouse ICOS (C137S, C138S) Protein, His Tag (Cat. No. ICS-M52H8) ELISA bioactivity

Immobilized Human B7-H2, Fc Tag (Cat. No. B72-H5254) at 5 μg/mL (100 μL/well) can bind Mouse ICOS (C137S, C138S) Protein, His Tag (Cat. No. ICS-M52H8) with a linear range of 39-625 ng/mL (QC tested).

  • Background
    Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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