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Your Position: Home > All Other Proteins > Siglec-10 > SI0-H52H9

Human Siglec-10 Protein, His Tag (MALS verified)

  • Synonym
    SIGLEC10,MGC126774,PRO940,Siglec10,SLG2
  • Source
    Human Siglec-10, His Tag (SI0-H52H9) is expressed from human 293 cells (HEK293). It contains AA Met 17 - Thr 546 (Accession # Q96LC7-1).
    Predicted N-terminus: Met 17
  • Molecular Characterization
    Online(Met 17 - Thr 546) Q96LC7-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 60.1 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 25 mM MES, 150 mM NaCl, Arginine, pH5.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Siglec-10, His Tag (Cat. No. SI0-H52H9) SDS-PAGE gel

Human Siglec-10, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human Siglec-10, His Tag (Cat. No. ) MALS images

The purity of Human Siglec-10, His Tag (Cat. No. SI0-H52H9) is more than 90% and the molecular weight of this protein is around 132-160 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human Siglec-10, His TagHuman Siglec-10, His Tag (Cat. No. SI0-H52H9) ELISA bioactivity

Immobilized Human Siglec-10, His Tag (Cat. No. SI0-H52H9) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Human siglec-10 Antibody, Human IgG1 with a linear range of 0.08-2 ng/mL (QC tested).

  • Background
    The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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