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Your Position: Home > All Other Proteins > ALK-7 > AL7-H52H5

Human ALK-7 Protein, His Tag

  • Synonym
    ALK-7,ACTR-IC,ACVR1C
  • Source
    Human ALK-7, His Tag (AL7-H52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Glu 113 (Accession # Q8NER5-1).
    Predicted N-terminus: Glu 21
  • Molecular Characterization
    Online(Glu 21 - Glu 113) Q8NER5-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 11.9 kDa. The protein migrates as 15-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 20 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human ALK-7, His Tag (Cat. No. AL7-H52H5) SDS-PAGE gel

Human ALK-7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

  • Background
    ALK-7 (Activin receptor-like kinase 7) is also known as Activin receptor type-1C, ACTR-IC, ACVR1C. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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