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Your Position: Home > All Other Proteins > TROP-2 > TR2-H5253

Human TROP-2 / TACSTD2 Protein, Fc Tag

  • Synonym
    TACSTD2,GA733-1,M1S1,TROP2
  • Source
    Human TROP-2, Fc Tag (TR2-H5253) is expressed from human 293 cells (HEK293). It contains AA His 27 - Thr 274 (Accession # P09758-1).
    Predicted N-terminus: His 27
  • Molecular Characterization
    Online(His 27 - Thr 274) P09758-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 54.3 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;

    2. -70°C for 3 months under sterile conditions after reconstitution.

SDS-PAGE
Human TROP-2, Fc Tag (Cat. No. TR2-H5253) SDS-PAGE gel

Human TROP-2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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