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Your Position: Home > All Other Proteins > Mucin-1 > MU1-H5254

Human Mucin-1 / MUC-1 (24-380) Protein, Fc Tag

  • Synonym
    Mucin 1,MUC1,CD227,EMA,H23AG,KL-6,MAM6,MUC-1,SEC,MUC-1,X,MUC1,ZD,PEM,PEMT,PUM,CA15-3,Episialin
  • Source
    Human Mucin-1 (24-380), Fc Tag (MU1-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 380 (Accession # P15941-1).
    Predicted N-terminus: Ser 24
  • Molecular Characterization
    Online(Ser 24 - Ser 380) P15941-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 60.2 kDa. The protein migrates as 70 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) SDS-PAGE gel

Human Mucin-1 (24-380), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Human Mucin-1 (24-380), Fc TagHuman Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) ELISA bioactivity

Immobilized Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) at 2 μg/mL (100 μL/well) can bind Monoclonal Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) with a linear range of 0.5-4 ng/mL (QC tested).

Human Mucin-1 (24-380), Fc TagHuman Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) ELISA bioactivity

Immobilized Monoclonal Anti-Mucin-1 Antibody, Mouse IgG1 (SM-3) at 2 μg/mL (100 μL/well) can bind Human Mucin-1 (24-380), Fc Tag (Cat. No. MU1-H5254) with a linear range of 0.2-2 ng/mL (Routinely tested).

  • Background
    Mucin-1 (MUC1) is also known as Tumor-associated epithelial membrane antigen (EMA), Polymorphic epithelial mucin (PEM), Peanut-reactive urinary mucin (PUM), PEMT, Krebs von den Lungen-6 (KL-6), CD antigen CD227, Episialin, H23AG. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the pathogen from reaching the cell surface. Except protective function by binding to pathogens, MUC1 also functions in a cell signaling capacity. Overexpression of MUC1 is often associated with colon, breast, ovarian, lung and pancreatic cancers.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Order Details

Price(USD) : $350.00

Price(USD) : $2310.00

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  • Latest Research Phase:Phase 3 Clinical

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