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Your Position: Home > Protein > LY75 > LY5-M52H5

Mouse LY75 / CD205 Protein, His Tag (MALS verified)

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  • Synonym
    LY75,CD205,DEC-205,CLEC13B,Lymphocyte antigen 75,gp200-MR6
  • Source
    Mouse LY75, His Tag (LY5-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 28 - Asp 1667 (Accession # Q60767-1).
    Predicted N-terminus: Ser 28
  • Molecular Characterization
    Online(Ser 28 - Asp 1667) Q60767-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 190.0 kDa. The protein migrates as 230-260 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

    >90% as determined by SEC-MALS.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Mouse LY75, His Tag (Cat. No. LY5-M52H5) SDS-PAGE gel

Mouse LY75, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

Mouse LY75, His Tag (Cat. No. ) MALS images

The purity of Mouse LY75, His Tag (Cat. No. LY5-M52H5) is more than 90% and the molecular weight of this protein is around 210-255 kDa verified by SEC-MALS.

  • Background
    lymphocyte antigen 75 (Ly 75, also known as CD205, CLEC13B, GP200-MR6 and DEC-205, is a type I transmembrane protein that is primarily expressed on dendritic cells and thymic epithelial cells. LY75 functions as an endocytic receptor for antigens. MEN1309/OBT076, the first antibody drug targeting CD205, has shown strong preclinical anti-tumor activity in lymphoma. After being verified as a single drug in vivo, the antibody-drug conjugate has a synergistic effect with the BCL2 inhibitor Venetoclax and the anti-cd20 monoclonal antibody rituximab.
  • Clinical and Translational Updates
  • Please contact us via if you have any question on this product.

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Price(USD) : $350.00

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