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Your Position: Home > Cytokines > HBEGF > HBF-H52H3

Human HBEGF Protein, His Tag

  • Synonym
    HBEGF, HB-EGF, Heparin-binding EGF-like growth factor, Diphtheria toxin receptor, DT-R, DTR, DTS, HEGFL
  • Source
    Human HBEGF, His Tag (HBF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 63 - Leu 148 (Accession # Q99075-1).
  • Molecular Characterization
    Online(Asp 63 - Leu 148) Q99075-1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 11.8 kDa. The protein migrates as 16-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human HBEGF, His Tag (Cat. No. HBF-H52H3) SDS-PAGE gel

Human HBEGF, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Human HBEGF, His TagHuman HBEGF, His Tag (Cat. No. HBF-H52H3) ELISA bioactivity

Immobilized Human HBEGF, His Tag (Cat. No. HBF-H52H3) at 5 μg/mL (100 μL/well) can bind Human EGF R, Fc Tag (Cat. No. EGR-H5252) with a linear range of 1-20 ng/mL (QC tested).

  • Background
    Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a ligand for the EGF receptor (EGFR) and a critical molecular component to a number of normal physiological processes including but not limited to tissue injury and wound healing, reproduction, angiogenesis and recently, adipogenesis. Misexpression of HB-EGF is linked to tumor formation and cancer including hepatocellular, pancreatic, gastric, breast, colon and melanoma, gliomas and glioblastomas.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $300.00

Price(USD) : $1980.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:1 Details
  • Latest Research Phase:Phase 2 Clinical

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