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Your Position: Home > All Other Proteins > ACE2 > AC2-H5255
  • Synonym
    ACE-2,ACEH,ACE2
  • Source
    Human ACE2, Fc Tag (AC2-H5255) is expressed from human 293 cells (HEK293).
  • Molecular Characterization

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 110.0 kDa. As a result of glycosylation, the protein migrates as 125-150 kDa under reducing (R) condition, and 250-300 kDa under non-reducing (NR) condition (SDS-PAGE).

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Supplied as 0.2 μm filtered solution in PBS, pH7.4.

    Contact us for customized product form or formulation.

  • Storage

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. The product MUST be stored at -70°C or lower upon receipt;
    2. -70°C for 12 months under sterile conditions.
  • Shipping
    This product is supplied and shipped as sterile liquid solution with dry ice, please inquire the shipping cost.
SDS-PAGE
Human ACE2, Fc Tag (Cat. No. AC2-H5255) SDS-PAGE gel

Human ACE2, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
Human ACE2, Fc Tag (Cat. No. ) MALS images

The purity of Human ACE2, Fc Tag(Cat. No. AC2-H5255) was more than 80% and the molecular weight of this protein is around 240-290 kDa verified by SEC-MALS.

Bioactivity-ELISA
Human ACE2, Fc TagHuman ACE2, Fc Tag (Cat. No. AC2-H5255) ELISA bioactivity

Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5255) at 2 μg/mL (100 μL/well) can bind Biotinylated SARS-CoV-2 S1 protein, His,Avitag (Cat. No. S1N-C82E8) with a linear range of 40-625 ng/mL (QC tested).

  • Background
    Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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