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Human Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer Protein, His Tag&Tag Free

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  • Synonym
    Integrin alpha X beta 2, ITGAX&ITGB2, CD11C, CD18
  • Source
    Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2) (Accession # P20702-1(ITGAX) & P05107-1(ITGB2)).
    Predicted N-terminus: Phe 20 (ITGAX) & Gln 23 (ITGB2)
  • Molecular Characterization
    Online-Res(Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2)) P20702-1 (ITGAX) & P05107-1 (ITGB2)

    Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAX and ITGB2, has a calculated MW of 126.6 kDa (ITGAX) and 80.1 kDa (ITGB2). Subunit ITGAX is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.

  • Endotoxin
  • Formulation

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  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
  • Background
    The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM)-1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.
  • References
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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