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Your Position: Home > TME Relevant Pathway > Integrin alpha X beta 2 > IT2-H52W3

Human Integrin alpha X beta 2 (ITGAX&ITGB2) Heterodimer Protein, His Tag&Tag Free

  • Synonym
    Integrin alpha X beta 2, ITGAX&ITGB2, CD11C, CD18
  • Source
    Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2) (Accession # P20702-1(ITGAX) & P05107-1(ITGB2)).
    Predicted N-terminus: Phe 20 (ITGAX) & Gln 23 (ITGB2)
  • Molecular Characterization
    Online(Phe 20 -Pro 1107 (ITGAX) & Gln 23 - Asn 700 (ITGB2)) P20702-1 (ITGAX) & P05107-1 (ITGB2)

    Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAX and ITGB2, has a calculated MW of 126.5 kDa (ITGAX) and 80.2 kDa (ITGB2). Subunit ITGAX is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The protein migrates as 145 kDa (ITGAX) and 90 kDa (ITGB2) under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT2-H52W3) SDS-PAGE gel

Human ITGAX&ITGB2 Heterodimer Protein, His Tag&Tag Free on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

  • Background
    The integrin αXβ2 takes a key role in host defense and functions as a receptor for the complement C3 cleavage product iC3b, fibrinogen, denatured proteins, and intercellular adhesion molecule (ICAM)-1. Integrin αXβ2 αXβ2 has a unique cellular distribution with expression on monocytes, macrophages, and the CD8− subsets of dendritic cells and involves in priming and regulation of the immune response.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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