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Your Position: Home > Protein > BCMA > BCA-C52H3

Canine BCMA / TNFRSF17 Protein, His Tag (MALS verified)

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  • Synonym
    TNFRSF17,CD269,BCM,BCMA
  • Source
    Canine BCMA, His Tag(BCA-C52H3) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Asn 44 (Accession # Q02223-1 ).
  • Molecular Characterization
    BCMA Structure

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 7.1 kDa. The protein migrates as 10-12 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
BCMA SDS-PAGE

Canine BCMA, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-MALS
BCMA MALS images

The purity of Canine BCMA, His Tag (Cat. No. BCA-C52H3) is more than 85% and the molecular weight of this protein is around 7-12 kDa verified by SEC-MALS.

Bioactivity-ELISA
 BCMA ELISA

Immobilized Canine BCMA, His Tag (Cat. No. BCA-C52H3) at 5 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.2-2 ng/mL (QC tested).

 BCMA ELISA

Immobilized Canine BCMA, His Tag (Cat. No. BCA-C52H3) at 5 μg/mL (100 μL/well) can bind Anti-BCMA Neutralizing Antibody, Mouse IgG1 (Cat. No. BCA-M43) with a linear range of 0.02-0.313 μg/mL (Routinely tested).

 BCMA ELISA

Immobilized Human APRIL, Fc Tag (Cat. No. APL-H5267) at 5 μg/mL (100 μL/well) can bind Canine BCMA, His Tag (Cat. No. BCA-C52H3) with a linear range of 0.2-1 ng/mL (Routinely tested).

  • Background
    Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
  • Clinical and Translational Updates

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ETD of in-stock products: 2 business days

Price(USD) : $350.00

Price(USD) : $2540.00

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