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Your Position: Home > All Other Proteins > BAFFR > BAR-C52H4

Cynomolgus BAFFR / TNFRSF13C Protein, His Tag

  • Synonym
    BAFFR,TNFRSF13C,BROMIX,CD268,CVID4,prolixin,BAFF-R
  • Source
    Cynomolgus BAFFR, His Tag (BAR-C52H4) is expressed from human 293 cells (HEK293). It contains AA Ser 7 - Gly 76 (Accession # A0A2K5V1K1).
  • Molecular Characterization
    Online(Ser 7 - Gly 76) A0A2K5V1K1

    This protein carries a polyhistidine tag at the C-terminus.

    The protein has a calculated MW of 9.1 kDa. The protein migrates as 14-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Cynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) SDS-PAGE gel

Cynomolgus BAFFR, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Bioactivity-ELISA
Cynomolgus BAFFR, His TagCynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) ELISA bioactivity

Immobilized Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) at 1 μg/mL (100 μL/well) can bind Cynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) with a linear range of 0.8-3 ng/mL (QC tested).

Cynomolgus BAFFR, His TagCynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) ELISA bioactivity

Immobilized Cynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) at 1 μg/mL (100 μL/well) can bind Anti-BAFFR Antibody, Human IgG1 with a linear range of 0.1-0.8 ng/mL (Routinely tested).

Cynomolgus BAFFR, His TagCynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) ELISA bioactivity

Immobilized Cynomolgus BAFFR, His Tag (Cat. No. BAR-C52H4) at 1 μg/mL (100 μL/well) can bind Human BAFF, Fc Tag, active trimer (Cat. No. BAF-H5261) with a linear range of 0.1-2 ng/mL (Routinely tested).

  • Background
    BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), is a membrane protein of the TNF receptor superfamily which recognizes BAFF. B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of BAFF in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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