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Your Position: Home > Protein > Plexin B2 > PL2-H52H3

Human Plexin B2 Protein, His Tag

  • Synonym
    Plexin B2,PLXNB2,KIAA0315,MM1,Plexin-B2
  • Source
    Human Plexin B2, His Tag(PL2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Arg 1160 (Accession # O15031-1 ).
  • Molecular Characterization
    Plexin B2 Structure

    This protein carries a polyhistidine tag at the C-terminus

    The protein has a calculated MW of 127.0 kDa. The protein migrates as 150-180 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Plexin B2 SDS-PAGE

Human Plexin B2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

 Plexin B2 ELISA

Immobilized Human Plexin B2, His Tag (Cat. No. PL2-H52H3) at 5 μg/mL (100 μL/well) can bind Human SEMA4D, Fc Tag (Cat. No. CD0-H5257) with a linear range of 0.039-1.25 μg/mL (QC tested).

  • Background
    Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
  • Clinical and Translational Updates
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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