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Your Position: Home > All Other Proteins > CEACAM-5 > CE5-H5253

Human CEACAM-5 Protein, Fc Tag (HPLC verified)

  • Synonym
    CEACAM-5,CD66e,CEA,Meconium antigen 100
  • Source
    Human CEACAM-5, Fc Tag (CE5-H5253) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Ala 685 (Accession # P06731-1).
    Predicted N-terminus: Lys 35
  • Molecular Characterization
    Online(Lys 35 - Ala 685) P06731-1

    This protein carries a human IgG1 Fc tag at the C-terminus.

    The protein has a calculated MW of 97.8 kDa. The protein migrates as 150-220 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >95% as determined by SDS-PAGE.

    >90% as determined by SEC-HPLC.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
Human CEACAM-5, Fc Tag (Cat. No. CE5-H5253) SDS-PAGE gel

Human CEACAM-5, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

SEC-HPLC
Human CEACAM-5, Fc Tag (Cat. No. ) HPLC images

The purity of Human CEACAM-5, Fc Tag (Cat. No. CE5-H5253) was greater than 90% as determined by SEC-HPLC.

Bioactivity-ELISA
Human CEACAM-5, Fc TagHuman CEACAM-5, Fc Tag (Cat. No. CE5-H5253) ELISA bioactivity

Immobilized Human CEACAM-5, Fc Tag (Cat. No. CE5-H5253) at 1 μg/mL (100 μL/well) can bind Labetuzumab with a linear range of 1-10 ng/mL (QC tested).

  • Background
    Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is also Carcinoembryonic antigen (CEA), Meconium antigen 100, CD antigen CD66e, CEACAM5 belongs to the immunoglobulin superfamily and CEA family. CEACAM5 contains seven Ig-like (immunoglobulin-like) domains. CEACAM5 is homodimer protein which binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5 is cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is receptor for E.coli Dr adhesins.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $300.00

Price(USD) : $1980.00

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Drug Development Status

  • Number of Launched Drugs:1 Details
  • Number of Drugs in Clinical Trials:12 Details
  • Latest Research Phase:Phase 3 Clinical

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