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Your Position: Home > All Other Proteins > CLEC12A > CLA-HP2Q3

PE-Labeled Human CLEC12A / MICL / CLL-1 Protein, His Tag (Site-specific conjugation)

  • Synonym
    CLEC12A,MICL,CLL-1,CLL1,DCAL2,DCAL-2,CD371
  • Source
    PE-Labeled Human CLEC12A, His Tag (CLA-HP2Q3) is produced via site-specific conjugation of PE to Human CLEC12A, His Tag under optimal conditions with a proprietary technology. Human CLEC12A, His Tag is expressed from human 293 cells (HEK293). It contains AA His 65 - Ala 265 (Accession # Q5QGZ9-2).
    Predicted N-terminus: Gly
  • Molecular Characterization
    Online(His 65 - Ala 265) Q5QGZ9-2

    This protein carries a polyhistidine tag at the N-terminus.

    The protein has a calculated MW of 27.3 kDa.

  • Application
    Evaluation of anti-CLEC12A CAR expression by flow cytometry (Please note that this product is NOT compatible to streptavidin detection system).
  • Conjugate

    PE

    Excitation source: 488 nm spectral line, argon-ion laser

    Excitation Wavelength: 488 nm

    Emission Wavelength: 575 nm

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, 0.5% BSA, pH7.4. Normally trehalose is added as protectant before lyophilization.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please protect from light and avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
Bioactivity-FACS
FACS assay shows that recombinant Biotinylated FACS

5e5 of anti-CLEC12A/CLL-1 CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Human CLEC12A, His Tag (Cat. No. CLA-HP2Q3) and negative control protein respectively. PE signal was used to evaluate the binding activity (QC tested).

  • Background
    CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL. Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years. The role of CLEC12A in MDS, however, remains to be elucidated. Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
  • Clinical and Translational Updates
      
  • Please contact us via TechSupport@acrobiosystems.com if you have any question on this product.

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Price(USD) : $319.00

Price(USD) : $1980.00

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Drug Development Status

  • Number of Launched Drugs:0 Details
  • Number of Drugs in Clinical Trials:5 Details
  • Latest Research Phase:Phase 3 Clinical

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DMF (Drug Master File)

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