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Your Position: Home > Protein > JAB1 > JA1-H5553

Human JAB1 / COPS5 Protein, Fc Tag

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  • Synonym
    JAB1
  • Source
    Human JAB1 Protein, Fc Tag(JA1-H5553) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Ser 334 (Accession # Q92905-1).
    Predicted N-terminus: Ala 2
  • Molecular Characterization
    JAB1 Structure

    This protein carries a human IgG1 Fc tag at the C-terminus

    The protein has a calculated MW of 63.9 kDa. The protein migrates as 33 kDa and 64-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

  • Endotoxin
    Less than 1.0 EU per μg by the LAL method.
  • Purity

    >90% as determined by SDS-PAGE.

  • Formulation

    Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

    Contact us for customized product form or formulation.

  • Reconstitution

    Please see Certificate of Analysis for specific instructions.

    For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

  • Storage

    For long term storage, the product should be stored at lyophilized state at -20°C or lower.

    Please avoid repeated freeze-thaw cycles.

    This product is stable after storage at:

    1. -20°C to -70°C for 12 months in lyophilized state;
    2. -70°C for 3 months under sterile conditions after reconstitution.
SDS-PAGE
JAB1 SDS-PAGE

Human JAB1 Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

  • Background
    Jab1, also known as CSN5, is a component of (COP9) signalosome complex (CSN) and reported to be involved in the regulation of cell proliferation, cell-cycle progression, and tumorigenesis. As a component of the COP9 signalosome complex, Jab1 could reciprocally regulate the stability and transcriptional activity of MED1 and might be a MED1 direct target gene mediating the aggressive phenotypes of HER2+tumors.
  • Clinical and Translational Updates

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